Effect of Neonatal Rat Bisphenol a Exposure on Performance in the Morris Water Maze

Carr, Russell L.; Bertasi, Frances R.; Betancourt, Angela M.; Bowers, S.; Gandy, B.; Ryan, Peter L.; Willard, Scott T.

doi:10.1080/713853983

Cited by 75 publications

(46 citation statements)

References 37 publications

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“…This hypothesis is not supported by previous studies demonstrating that males perform similarly as or better than females in classical tests of hippocampal functioning such as spatial memory in a Morris water maze (i.e. Bucci et al, 1995;Carr et al, 2003;Perrot-Sinal et al, 1996;Roof and Stein, 1999;SilvaGomez et al, 2003;Wagner et al, 2004;Wang et al, 2000).…”

Section: Accepted M Manuscriptcontrasting

confidence: 48%

Sex differences in the behavioural and hypothalamic–pituitary–adrenal response to contextual fear conditioning in rats

Daviu

Andero

Armario

et al. 2014

Hormones and Behavior

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SummaryIn recent years, special attention is being paid to sex differences in susceptibility to disease. In this regard, there is evidence that male rats present higher levels of both cued and contextual fear conditioning than females. However, little is known about the concomitant hypothalamicpituitary-adrenal (HPA) axis response to those situations which is critical in emotional memories.Here, we studied the behavioural and HPA responses of male and female Wistar rats to context fear conditioning using electric footshock as the aversive stimulus. Fear-conditioned rats showed a much greater ACTH and corticosterone response than those merely exposed to the fear conditioning chamber without receiving shocks. Moreover, males presented higher levels of freezing whereas HPA axis response was greater in females. Accordingly, during the fear extinction tests, female rats consistently showed less freezing and higher extinction rate, but greater HPA activation than males. Exposure to an open-field resulted in lower activity/exploration in fear-conditioned males, but not females, suggesting greater conditioned cognitive generalization in males than females. It can be concluded that important sex differences in fear conditioning are observed in both freezing and HPA activation, but the two set of variables are affected in the opposite direction: enhanced behavioural impact in males, but enhanced HPA responsiveness in females. Thus, the role of sex differences on fear-related stimuli may depend on the variables chosen to evaluate it, the greater responsiveness of the HPA axis in females perhaps being an important factor to be further explored.

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Section: Accepted M Manuscriptcontrasting

confidence: 48%

Sex differences in the behavioural and hypothalamic–pituitary–adrenal response to contextual fear conditioning in rats

Daviu

Andero

Armario

et al. 2014

Hormones and Behavior

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show abstract

“…This task was first developed to assess hippocampal-based spatial navigation learning in rats [21] and is now widely adopted for rodent models of traumatic brain injury [22] and neurodegenerative disorders [23]. It has also been extensively used in assessment of the cognitive effects of specific exposures [24][25][26][27]. Study investigators involved in behavioral testing were blinded to treatments groups of each rat.…”

Section: Methodsmentioning

confidence: 99%

Chronic Treatment with Naltrexone Prevents Memory Retention Deficits in Rats Poisoned with the Sarin Analog Diisopropylfluorophosphate (DFP) and Treated with Atropine and Pralidoxime

2015

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Humans and rats poisoned with sarin develop chronic neurological disabilities that are not prevented with standardized antidotal therapy. We hypothesized that rats poisoned with the sarin analogue diisopropylfluorophosphate (DFP) and resuscitated with atropine and pralidoxime would have long-term memory deficits that were preventable with naltrexone treatment. Long Evans rats (250-275 g) were randomized to: DFP (N=8): single subcutaneous (SC) injection of DFP (5 mg/kg). Treatment (N=9): DFP (5 mg/kg) followed by chronic naltrexone (5 mg/kg/day × 12 weeks). Control (N= 12): single SC injection of isopropyl alcohol, (DFP vehicle) followed by chronic naltrexone (5 mg/kg/day). If toxicity developed after injection, antidotal therapy was initiated with atropine (2 mg/kg) and pralidoxime (25 mg/kg) and repeated as needed. After 12 weeks, rats underwent testing for place learning (acquisition) across 5 days of training using the Morris Water Maze. On day 6 a memory retention test was performed. Statistical analysis was performed using IBM SPSS Statistics. Rats receiving DFP rapidly developed toxicity requiring antidotal rescue. No differences in acquisition were seen between the DFP vs. DFP+naltrexone rats. During memory testing, DFP-poisoned rats spent significantly less time (29.4±2.11 versus 38.5±2.5 s, p<0.05) and traveled less distance (267±24.6 versus 370±27.5 cm, p<0.05) in the target quadrant compared to the treatment group. Treatment rats performed as well as control rats (p>0.05) on the test for memory retention. Poisoning with DFP induced impaired memory retention. Deficits were not prevented by acute rescue with atropine and pralidoxime. Chronic naltrexone treatment led to preserved memory after DFP poisoning.

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“…Carr et al (2003), supported by the National Science Foundation, the Mississippi Agricultural and Forestry Experiment Station, and the College of Veterinary Medicine at Mississippi State University, examined the effects of bisphenol A exposure on performance of rats in the Morris water maze. In this study, F344 rat dams and pups were fed Purina Test Diet 8117, a casein-based rodent chow.…”

Section: Utility (Adequacy) For Cerhr Evaluation Processmentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

398

302

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Effect of Neonatal Rat Bisphenol a Exposure on Performance in the Morris Water Maze

Cited by 75 publications

References 37 publications

Sex differences in the behavioural and hypothalamic–pituitary–adrenal response to contextual fear conditioning in rats

Sex differences in the behavioural and hypothalamic–pituitary–adrenal response to contextual fear conditioning in rats

Chronic Treatment with Naltrexone Prevents Memory Retention Deficits in Rats Poisoned with the Sarin Analog Diisopropylfluorophosphate (DFP) and Treated with Atropine and Pralidoxime

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

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