Effect of Nauclea subdita (Korth.) Steud. leaf extract on hematological and histopathological changes in liver and kidney of striped catfish infected by Aeromonas hydrophila

Abstract

<jats:p>Aim: The present study was conducted to investigate the efficacy of different doses of Bangkal (Nauclea subdita) leaf extract on hematological and histological changes in kidney and liver of catfish (Pangasius hypophthalmus) infected by Aeromonas hydrophila. Materials and Methods: Catfish were experimentally infected with A. hydrophila at a dose of 108 cells/mL through intraperitoneal injection, and the hematological and histological changes in the kidney and liver of catfish against the pathogen were observed. Results: Not all concentrations of N. subdita caused a toxic effect in striped catfish. The clinical symptoms of catfish after infection with A. hydrophila and treatment with N. subdita leaf extract included morphological and behavioral changes. N. subdita leaf extract reduced mortality caused by A. hydrophila. Treatment with N. subdita leaf extract was effective in reducing the inflammation by decreasing the activity of neutrophils, monocytes, and lymphocytes. The Hb and Ht levels of catfish significantly decreased after exposure to 108 cells/mL of A. hydrophila and increased significantly after N. subdita treatment. Necrosis percentages in the kidney and liver also decrease after N. subdita treatment. Conclusion: The results indicate that N. subdita leaf extract stimulates the immunity and increases the resistance of catfish to A. hydrophila. N. subdita leaf extract may be used as a potential source for future drug development and food applications.</jats:p>

Evaluation of dietary inclusion of Bunium persicum, Bunium persicum essential oil on growth, immune components, immune‐related gene expressions and resistance to Aeromonas hydrophila , in rainbow trout, Oncorhynchus mykiss

“…In agreement with our results, the liver tissue damages have been also reported in other fish, following the challenge with bacteria, A. hydrophila (Grizzle & Kiryu, 1993;Hamid et al, 2016;Kumar et al, 2016;Wang et al, 2017). Furthermore, there are a few studies, indicating the protective effects of plant-based supplements on liver tissue (Aisiah et al, 2020;Moustafa et al, 2020).…”

“…hydrophila (Grizzle & Kiryu, 1993; Hamid et al, 2016; Kumar et al, 2016; Wang et al, 2017). Furthermore, there are a few studies, indicating the protective effects of plant‐based supplements on liver tissue (Aisiah et al, 2020; Moustafa et al, 2020).…”

Assessing the susceptibility of the selected gourami (Osphronemus goramy) to Aeromonas hydrophila

“…LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of increased toxicity (Aisiah et al 2020). Growth and survival are the major character in the aquaculture system and most selection programs focused on these traits (Krishna et al 2011;Gjedrem et al 2012).…”

The Effect of Adding Chitosan Nanoparticles Loaded with Sidr Leaf Extract (Ziziphus spina-christi) (CPNs SLE) in Diet on Pangasius sp. Infected Aeromonas hydrophila

“…Motile Aeromonas Septicaemia (MAS) represents a significant threat to freshwater fish populations, resulting in substantial economic losses due to its alarmingly high mortality rates, which can reach 80-100% within a short timeframe of 1-2 weeks [1]. Treating infected fish incurs elevated production costs.…”