Effect of nanosilver on blood parameters in chickens having aflatoxicosis

Abstract

This experiment is designed to investigate the positive effects of commercial nanosilver compound on blood parameters in experimental aflatoxicosis in broiler chickens. For this, 270 one-day-old broiler chickens were randomly divided into six treatment groups with three replicates. The experimental groups were group A: chickens fed with basal diet; group B: chickens fed with 3 ppm productive aflatoxin in basal diet; groups of C, D, E and F received Mycoad (2.5 g/kg diet), Mycoad (2.5 g/kg diet) + productive aflatoxin (3 ppm), Nanocid (2500 ppm), and Nanocid (2500 ppm) + productive aflatoxin (3 ppm) in basal diet, respectively. Results revealed that some of the blood parameters such as mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration lymphocytes, neutrophils, basophils, monocytes, and eosinophils percentage were not affected in this experiment; whereas, hemoglobin percentage and white blood cell (WBC) count in all the groups fed with 3 ppm aflatoxin except nanocid + aflatoxin decreased significantly (p < 0.05). There are no significant differences between the groups that received nanocid + aflatoxin and mycoad + aflatoxin in hemoglobin percentage and WBC count parameters. The red blood cell count and hematocrit in chickens received aflatoxin were significantly lower than other groups (p < 0.05). Therefore, this study suggests that nanocid similar as mycoad can be useful in reducing the adverse effects of aflatoxin on blood parameters in chickens affected with aflatoxicosis.

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

“…The study concluded that supplement of nanosilver to diet containing aflatoxin could diminish the inhibitory effects of aflatoxin [ 123 ]. Similarly, the same authors further demonstrated that nanosilver, as mycoad, can be useful in reducing the adverse effects of aflatoxin on blood parameters in chickens that are affected with aflatoxicosis [ 124 ]. The combination of nanocrystalline silver and subatmospheric pressure therapy shows significant effect in cat after following tumour removal and radiation therapy [ 125 ].…”

Antifungal Activity of Juglans-regia-Mediated Silver Nanoparticles (AgNPs) against Aspergillus-ochraceus-Induced Toxicity in In Vitro and In Vivo Settings

“…The levels were however found to be improved in group C (toxin + 20 µg AgNPs) and group D (toxin + 50 µg AgNPs) with a subsequent decline in the concentrations again in the case of group E (toxin + 70 µg AgNPs), thus proving the dose of 70 µg AgNPs to be toxic. Ahangaran and Jahromi [109] also showed the therapeutic potential of nanosilver in overcoming the harmful impacts induced by aflatoxins in chickens. Values were represented as mean ± SD.…”

Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

“…The ZnNPs and AgNPs can inhibit the growth of Fusarium poae and prevent formation of trichothecenes mycotoxin [ 16 ]. The Ag NPs can eliminate aflatoxins in chickens feed [ 95 , 96 ]. Biosynthesized spherical SeNPs produced by Saccharomyces cerevisiae and originated from selenous acid and sodium sulfite were able to inhibit pathogenic saprophytes, yeasts, and dermatophytes [ 97 ].…”

“…The nanocomposites derived from metal oxide and carbon nanomaterials have also been evaluated for anti-mycotoxin properties. A magnetic carbon nanocomposite derived from bagasse was observed to degrade AFB1 [ 105 ], while graphene oxide nanocomposites caused a reduction in the occurrence of three prominent Fusarium toxins i.e., ZEA, FB, and deoxynivalenol [ 106 ] and modified halloysite nanotubes [ 96 , 107 ]. Also, detoxification of AFB1 by a magnetic graphene oxide nanocomposite has been reported by Ji and Xie [ 108 ].…”