Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Alghuthaymi, Mousa A.; Hassan, Atef A.; Kalia, Anu; Ahl, Rasha M.H. Sayed El; Hamaky, Ahmed A. M. El; Olekšák, Patrik; Kuča, Kamil; Abd-Elsalam, Kamel A.

doi:10.3390/jof7070494

Cited by 18 publications

(13 citation statements)

References 159 publications

(264 reference statements)

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“…In this regard, nanotechnology-based approaches exhibit improved inhibitory activity on fungal pathogens at lower concentrations. Nanocarriers also assist in the targeted delivery of antifungal drugs [23].…”

Section: Nanocarriers In Management Of Fungal Infectionsmentioning

confidence: 99%

Nanoarchitectures in Management of Fungal Diseases: An Overview

Mishra

Singh

Mishra³

et al. 2021

Applied Sciences

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Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of their mild existence and negligible resistance of infections to antifungal bioactivities. Nanotechnology-based carriers have gained much attention due to their magnificent abilities. Nanoarchitectures have served as excellent carriers/drug delivery systems (DDS) for delivering antifungal drugs with improved antifungal activities, bioavailability, targeted action, and reduced cytotoxicity. This review outlines the different fungal diseases and their treatment strategies involving various nanocarrier-based techniques such as liposomes, transfersomes, ethosomes, transethosomes, niosomes, spanlastics, dendrimers, polymeric nanoparticles, polymer nanocomposites, metallic nanoparticles, carbon nanomaterials, and nanoemulsions, among other nanotechnological approaches.

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Section: Nanocarriers In Management Of Fungal Infectionsmentioning

confidence: 99%

Nanoarchitectures in Management of Fungal Diseases: An Overview

Mishra

Singh

Mishra³

et al. 2021

Applied Sciences

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“…The most recovered pathogens of animal diarrhea were Staphylococcus sp., Streptococcus sp., E. coli, C. albicans, and A. flavus (Chen et al 2012;Hassan et al 2016;2019a;2020b). Several authors reported that these infections resulted from the prolonged use of antibiotics, which caused multidrug resistance (MDR) among infectious pathogens (Williams 2000;Jeykumar et al 2013;Alghuthaymi et al 2021). This MDR can spread widely between pathogens (Daka and Yihdego 2012;Hassan et al 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, new effective drugs that can manipulate the MDRG are urgently required to be used (Singh et al 2018;Hassan et al 2022). Nano-sized materials of metals have emerged as a new approach for detecting efficient agents for resolving the drugs resistance problem to traditional antibiotics (Hassan et al 2021;2022;Alghuthaymi et al 2021). Moreover, metallic nanoparticles such as ZnNPs, CuNPs, and AgNPs have antioxidant effects besides the antimicrobial potential (Fouda et al 2020;Hassan et al 2020aHassan et al , 20212022;Alghuthaymi et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Nano-sized materials of metals have emerged as a new approach for detecting efficient agents for resolving the drugs resistance problem to traditional antibiotics (Hassan et al 2021;2022;Alghuthaymi et al 2021). Moreover, metallic nanoparticles such as ZnNPs, CuNPs, and AgNPs have antioxidant effects besides the antimicrobial potential (Fouda et al 2020;Hassan et al 2020aHassan et al , 20212022;Alghuthaymi et al 2021). It has been reported that ZnONPs have a wide range of effects on several foodborne pathogens like E. coli, Salmonella, and S. aureus (Abd-Elsalam 2021; Alghuthaymi et al 2021;Hassan et al 2022).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Copper and Zinc Nanoparticles on Genotyping Characterizations of Multi-Drug Resistance Genes for Some Calf Pathogens

2022

Int J Vet Sci

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Nowadays there is a worldwide problem in the control of animal diseases due to the multidrug resistance of pathogens. Fecal samples, pharyngeal swabs, and rations were examined for cases of respiratory and diarrhea infections in calves. The most predominant species were A. flavus and E. coli pathogens. The drug-resistance against A. flavus and E. coli was tested. Nanotechnology was used and evaluated to overcome the drug resistance to conventional drugs. Herein, ZnONPs and CuNPs were used instead of commercial antibiotics against A. flavus and E. coli pathogens. They suppressed the growth and viability of A. flavus and E. coli sp., and the MIC was (600μg/mL). In addition, the molecular detection of virulent genes such as A. flavus (aflR) and E. coli (stx1) confirmed their conventional identification. In addition, the isolates were PCR tested for multidrug resistance (MDR) genes using primers for the Azole resistance gene (CYP51) in A. flavus and ampicillin resistance gene (CITM) in E. coli. The treated isolates with ZnONPs and CuNPs at high doses, 600μg/mL and 150μg/mL, eliminated the signals of DNA bands of MDR genes, respectively. Whereas the expression of genes was observed with the treatment of E. coli and A. flavus with low doses of 100 and 50μg/mL of ZnONPs and CuNPs, respectively. The exposure of pathogens to high doses of ZnONPs and CuNPs (600 and 150μg/mL) prevents mutation of the azole resistance gene (CYP51) in fungi and ampicillin resistance gene (CITM) in bacteria. Hence, the supplementation of ZnONPs and CuNPs for rations can inhibit the microbial viability and removal of drugs resistant genes.

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“…In addition, the existing and potential applications of zinc-based nanostructures in plant disease diagnosis and control, as well as their safety in the agroecosystem, are discussed [17]. The development of antifungal nanohybrid agents containing conjugates of organic or inorganic compounds, biological components and biopolymers was researched in order to generate cheaper, more dependable and effective product(s) against most fungal infections of plants and animals [18,19]. Metal-bionancomposites such as Cu-Chit/NCS hydrogel are novel nano-fungicides created by metal vapor synthesis (MVS) that are used in food and feed to promote plant defense against toxigenic fungus, such as Aspergillus flavus linked with peanut meal and cotton seeds [20].…”

Section: Introductionmentioning

confidence: 99%