Influence of Copper and Zinc Nanoparticles on Genotyping Characterizations of Multi-Drug Resistance Genes for Some Calf Pathogens

doi:10.47278/journal.ijvs/2022.195

Cited by 7 publications

(7 citation statements)

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“…Moreover, subclinical mastitis has several adverse problems in animals and their productivity, in addition to its zoonotic ability via the consumption of infected milk and other products (Khazaie and Ahmadi, 2021). Hence, more attention was undertaken to control the growth of pathogenic causes by conventional drugs, but frequent uses of this antimicrobial agent initiated the drug resistance of these pathogens (El-Hamaky et al, 2022). So, there are urgent requirements for novel and effective agents to eliminate the viability and growth of animal pathogens to overcome drug resistance (Fahmy et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, the progressive advancements in the application of nanotechnology in veterinary medicine potentiate the production of new agents of antifungals and antimicrobials (Weiss et al, 2006, Hassan et al, 2020ac, 2021El-Hamaky et al, 2022). They detected the multi drugs resistant genes in some bacterial and fungal strains and the elimination of their DNA signals expression by copper and zinc nanoparticles and a hybrid of Copper-Chitosan nanocomposites, which in successful antifungals and antibacterial potentials.…”

Section: Introductionmentioning

confidence: 99%

“…For example, ZnONPs is used as a food supplement to treat zinc deficiency and are effective against a wide range of strains such as E. coli, Salmonella, and S. aureus (Jones et al, 2008 andLiu et al, 2009;Hassan et al, 2020 a&b;. In addition, several medicinal plants and their oils have significant abilities for eliminating and suppressing the growth of pathogens causing bovine mastitis (Lopes et al, 2020;El-Hamaky et al, 2022). The most famous plant powder of wide use is Curcumin, which has an active principal chemical compound (Tumeric acid) that enables therapeutic effects against several disorders such as inflammations, alimentary tract affections, and tumors ( Goel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Zinc Oxide Nano particles and Curcumin effect on some virulence genes of Staphylococcus aureus and Candida albicans causing subclinical mastitis in buffalo

El-Hamaky

Mohamed²,

El-Khalek³

et al. 2023

Egyptian Journal of Agricultural Research

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Nowadays, there are progressive advancements in the biomedical employment of nanotechnology in human and animal health. Today, the dangers of infectious animal diseases and the continuous application of traditional antibiotics resulted in the elevation of the activities of the drugs resistant genes and the failure of their control. Hence, it is necessary to prevent fungal and bacterial pathogens pollution and their toxicity in dairy animal products. Sixty samples were collected from dairy buffalo farms suffering from subclinical mastitis (20 Samples of each from subclinical mastitis milk, animal feeds, and bedding). The species of Staphylococcus is considered the most predominant species, and Staphylococcus aureus was the most prevalent bacterial isolate. While, yeast, especially Candida albicans, was the most dominant fungal isolate from different samples of dairy buffalo farms. Our antibiogram of S. aureus and Candida albicans showed a high resistance rate against several traditional antimicrobial agents. Therefore, searching for effective drug materials to overcome drug resistance is needed. Herein, ZnONPs and Curcumin are evaluated singly and, in a composite, to inhibit the growth of C. albicans and S. aureus. The inhibitory dose of ZnONPs for C. albicans and S. aureus were (600 and 600 μg /ml) and in Curcumin were (2% and 3%), respectively. However, the hybrid nanocomposite of ZnONPs (100 μg/ml) with Curcumin (0.25% and 1%) caused suppression of the growth of these pathogens. The nanocomposite of low levels of ZnONPs (100 μg /ml) with (0.25% curcumin) significantly increased the inhibitory effects against C. albicans and S. aureus. The molecular study to detect the efficiency of the treatment doses indicated that the exposure of C. albicans and S. aureus to a low dose of ZnONPs (100 µg/ml) did not affect the DNA expression of virulent genes. While the high dose (600 µg/ml) prevented the DNA expression. However, in the Curcumin treatments of isolates with low doses (0.25), the genes' DNA expression was not affected. While, the high dose (1%), removed the DNA band. All inhibition and removal of virulent genes' DNA of pathogens can be obtained by the combination of low levels of ZnONPs and Curcumin. Hence, it is concluded that the nanocomposites of ZnONPs and Curcumin caused significant effects against pathogens.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Zinc Oxide Nano particles and Curcumin effect on some virulence genes of Staphylococcus aureus and Candida albicans causing subclinical mastitis in buffalo

El-Hamaky

Mohamed²,

El-Khalek³

et al. 2023

Egyptian Journal of Agricultural Research

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“…One of the main risks to human health has been shown to be heavy metal toxicity [1]. The class of metalloids and metals having an atomic density of more than or equal to 4,000 kg/m3 comprises heavy metals [2]. Animals can take up metals and other environmental components from food, water, sediment, and the air [3,4].…”

Section: Introductionmentioning

confidence: 99%

Heavy Metals in Poultry Chicken and Human Health Threat: A Mini Review

Hoque,

Roshed,

Md Asaduzzaman

2023

Middle East Res J Humanities Soc Sci

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It has been shown that the most hazardous heavy metals that are constantly emitted into the environment are arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg). These metals can be found in both naturally occurring and artificially produced fertilizers, industrial processes, and waste disposal. Due to ongoing exposure to heavy metals, bioaccumulation of As, Pb, Cd, and Hg takes place in a variety of organs in chickens, primarily the kidneys, liver, reproductive organs, and lungs. Chemical, biological, or physical risks can be connected to animal feed. Poultry feed contamination can come from negligent or intentional handling, storage, and transportation practices. Because of the increased concentration of these heavy metals in these tissues—primarily the brain, liver, kidneys, and reproductive organs—chronic exposure to low doses of As, Pb, Cd, and Hg can alter the microscopic structure of these tissues. This puts human health at risk when consuming chicken or poultry. Risks to food safety should be carefully considered in order to reduce unfavorable side effects in both people and animals. Governments should therefore implement stringent measures to prevent any harmful contamination that could endanger public health. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry with the associated problem of consumption of poultry and human health.

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“…Heavy metals are members of the class of metalloids and metals with an atomic density greater than or equal to 4,000 kg/m3 ( 1 ). Animals can absorb environmental elements and metals from the air, water, sediment, and food ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Heavy metal toxicity in poultry: a comprehensive review

Aljohani

2023

Front. Vet. Sci.

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Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources and from anthropogenic production of fertilizers, industrial activities, and waste disposal. Therefore, As, Cd, Hg, and Pb are found in increasing concentrations in bodies of water, fodder, feed, and in the tissues of livestock, including poultry, in the surroundings of industrial areas, leading to metabolic, structural, and functional abnormalities in various organs in all animals. In poultry, bioaccumulation of As, Pb, Cd, and Hg occurs in many organs (mainly in the kidneys, liver, reproductive organs, and lungs) as a result of continuous exposure to heavy metals. Consumption of Cd lowers the efficiency of feed conversion, egg production, and growth in poultry. Chronic exposure to As, Pb, Cd, and Hg at low doses can change the microscopic structure of tissues (mainly in the brain, liver, kidneys, and reproductive organs) as a result of the increased content of these heavy metals in these tissues. Histopathological changes occurring in the kidneys, liver, and reproductive organs are reflected in their negative impact on enzyme activity and serum biochemical parameters. Metal toxicity is determined by route of exposure, length of exposure, and absorbed dosage, whether chronic and acute. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry and the associated histopathological changes and toxic concentrations in different tissues.

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Influence of Copper and Zinc Nanoparticles on Genotyping Characterizations of Multi-Drug Resistance Genes for Some Calf Pathogens

Cited by 7 publications

References 47 publications

Evaluation of Zinc Oxide Nano particles and Curcumin effect on some virulence genes of Staphylococcus aureus and Candida albicans causing subclinical mastitis in buffalo

Evaluation of Zinc Oxide Nano particles and Curcumin effect on some virulence genes of Staphylococcus aureus and Candida albicans causing subclinical mastitis in buffalo

Heavy Metals in Poultry Chicken and Human Health Threat: A Mini Review

Heavy metal toxicity in poultry: a comprehensive review

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