Effect of Nanodisperse Ferrite Cobalt (CoFe2O4) Particles on Contractile Reactions in Guinea Pigs Airways

Abstract

The effect of nanopowder CoFe(2)O(4)on contractile responses of smooth-muscle segments of guinea pigs airways was studied by mechanography. Both in vivo inhalation of nanopowder aerosol or in vitro application of nanopowder to isolated airway segments increased the amplitude of contractile responses to histamine and potentiated the dilatory reaction to adrenergic salbutamol.

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

“…Cobalt ferrite NPs induce toxic responses (cytotoxicity & genotoxicity) in organisms; humans (Azaria et al, 2013), algae (Barhoumi and Dewez, 2013), mice (Hwang et al, 2012) and guinea pig (Kapilevich et al, 2010). Cobalt ferrite (CoFe 2 O 4 ) NPs causes decreased cytokinesis-blocked proliferation and increase of micro-binucleated lymphocytes (Colognato et al, 2007).…”

“…Cobalt ferrite (CoFe 2 O 4 ) NPs causes decreased cytokinesis-blocked proliferation and increase of micro-binucleated lymphocytes (Colognato et al, 2007). CoFe 2 O 4 NPs induce oxidative stress in guinea pigs (Kapilevich et al, 2010) and human lungs, liver (Human & mice), kidney, intestine, lymphoblasts and primary mouse dendritic-cells (Azaria et al, 2013;Hwang et al, 2012). CoFe 2 O 4 NPs also proved lethal to artificial and biological membranes.…”

An in vivo evaluation of acute toxicity of cobalt ferrite (CoFe2O4) nanoparticles in larval-embryo Zebrafish (Danio rerio)

“…( Barhoumi and Dewez., 2013;Azaria et al, 2013;Kapilevich et al, 2010). Cobalt ferrite (CoFe 2 O 4 ) NPs causes cleavage furrow regression and promotes cancerous cells by paralyzing the immune system (Colognato et al, 2007).…”

“…Cobalt ferrite (CoFe 2 O 4 ) NPs causes cleavage furrow regression and promotes cancerous cells by paralyzing the immune system (Colognato et al, 2007). CoFe 2 O 4 NPs induce respiratory disruptions in guinea pigs (Kapilevich et al, 2010) and human lungs as well. CoFe 2 O 4 NPs promote ROS dependent oxidative stress in liver (Human & mice), kidney, intestine, lymphoblasts cell lines and primary mouse dendritic-cells (Azaria et al, 2013;Hwang et al, 2012).…”

Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe2O4) nanoparticles in zebrafish larvae

“…(Kapilevich et al, ; Azaria et al, ; Barhoumi and Dewez, 2013; Ahmad et al ). Cobalt ferrite (CoFe 2 O 4 ) NPs perturbs cell cycle, promotes uncontrolled proliferation of cells, respiratory disorder (Kapilevich et al, ) by dismantling the immune system (Colognato et al, ; Hwang et al, ). CoFe 2 O 4 NPs promote ROS‐dependent oxidative stress in liver, kidney, intestine, and lymphoblasts cell lines (Azaria et al, ).…”