An in vivo evaluation of acute toxicity of cobalt ferrite (CoFe2O4) nanoparticles in larval-embryo Zebrafish (Danio rerio)

Ahmad, Farooq; Liu, Xiaoyi; Zhou, Ying; Yao, Hongzhou

doi:10.1016/j.aquatox.2015.07.003

Cited by 84 publications

(51 citation statements)

References 43 publications

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“…Higher activities of mu-GST and AP are also indicative of increased metabolic rates (Clemente et al, 2014). Activation of antioxidant defense mechanism contain CAT, AP and mu-GST are possibly very complex (Ahmad et al, 2015) as their principal function is to neutralize the ROS species in every compartment of a cell. While the toxicity of CoFe 2 O 4 NPs by ROS production can be attributed mainly to CoFe 2 O 4 NPs compared to Fe 3+ and Co 2+ .…”

Section: Discussionmentioning

confidence: 99%

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Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

2015

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Section: Discussionmentioning

confidence: 99%

“…It is because the release of ions was greatly impeded by agglomeration/aggregation process. The aggregates/agglomerates also provide the surface area for ions to be adsorbed, resulting in lesser toxic effect from the released ions (Ahmad et al, 2015). Bioaccumulations of NBs distress the specific functions in different cellular compartments.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

2015

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“…These two properties have allowed using these NPsin vaccines and bactericidal compounds in aqueous environments (Ghobadian et al 2015). Studies on inorganic NP have shown that, even at sublethal concentrations, these NPs can cause alterations in the hatching rate, malformations, survival and production of reactive oxygen species (Ahmad et al 2015;Ašmonaitė et al 2016;Fang et al 2015;Ghobadian et al 2015;Hu et al 2017;Wehmas et al 2015;Zhao et al 2013). Fent et al (2010) managed to achieve a fluorescent silica nanoparticle nontoxic for zebrafish embryos.…”

Section: Chen Et Al 2011mentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro-and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish. Special focus is made on morphological abnormalities, altered development and abnormal behavior. The last part of the review debates changes that should be made in future directions in order to improve the use of the zebrafish model to assess nanotoxicity.

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“…However little is known about the in vivo fate of nanoparticles metallic dopants such as cobalt. The potential toxicity of CoIONPs is a subject of debate with regards to environmental, health and safety issues connected to their application in nanomedicine212223. Natural organic matter as well as cellular media can promote degradation of CoIONPs resulting in possible release of Co 2+ and Fe 3+ /Fe 2+ into the environment2425.…”

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confidence: 99%

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

Volatron

Kolosnjaj‐Tabi

Javed

et al. 2017

Sci Rep

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Metallic nanoparticles have been increasingly suggested as prospective therapeutic nanoplatforms, yet their long-term fate and cellular processing in the body is poorly understood. Here we examined the role of an endogenous iron storage protein – namely the ferritin – in the remediation of biodegradable cobalt ferrite magnetic nanoparticles. Structural and elemental analysis of ferritins close to exogenous nanoparticles within spleens and livers of mice injected in vivo with cobalt ferrite nanoparticles, suggests the intracellular transfer of degradation-derived cobalt and iron, entrapped within endogenous protein cages. In addition, the capacity of ferritin cages to accommodate and store the degradation products of cobalt ferrite nanoparticles was investigated in vitro in the acidic environment mimicking the physiological conditions that are present within the lysosomes. The magnetic, colloidal and structural follow-up of nanoparticles and proteins in the lysosome-like medium confirmed the efficient remediation of nanoparticle-released cobalt and iron ions by ferritins in solution. Metal transfer into ferritins could represent a quintessential process in which biomolecules and homeostasis regulate the local degradation of nanoparticles and recycle their by-products.

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An in vivo evaluation of acute toxicity of cobalt ferrite (CoFe2O4) nanoparticles in larval-embryo Zebrafish (Danio rerio)

Cited by 84 publications

References 43 publications

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

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