Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years

Abstract

Our results show that a 6 month supplementation including physiological dosages of B vitamins improves the status of these nutrients and reduces tHcy in presumed healthy elderly women.

CSF/Serum Folate Gradient: Physiology and Determinants with Special Reference to Dementia

“…Analyses were done on the subgroup (n = 159) with serum folate ^ 35 nmol/l [33] . The subjects not included in this analysis had the following diagnoses: 3 patients with Lewy body dementia, 2 with alcohol dementia, 3 with frontotemporal dementia and 10 with unspecified dementia (F03 according to ICD-10).…”

“…Design of the Dementia, Genetic and Milieu Study in Öre-bro. Serum folate cutoff at 35 nmol/l differentiates quite well between supplement users and nonusers [33] . NUD = Unspecified dementia.…”

“…The only reasonable cause of such high levels of serum folate would be the intake of folate/B-vitamin supplements. In fact a serum folate cutoff at 35 nmol/l differentiates quite well between supplement users and nonusers [33] . The diagnoses were divided into 3 groups: ND (n = 73), vascular dementia (VaD) + mixed dementia (n = 44) and AD (n = 42).…”

The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Cross-Sectional Study

“…Randomized trials in adults taking 6 to 9 mcg of B 12 daily show effects of higher serum B 12 levels compared with placebo. 26,27 There are no known studies specifically evaluating whether a daily multivitamin prevents B 12 deficiency. Our findings may be noteworthy because conventional treatment of B 12 deficiency is with high dose oral supplementation or B 12 injections.…”

The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1mice

“…The effects of pyridoxine deficiency in both human and experimental animals have been reported and include: delayed growth; seborrhea and pellagra-like dermatitis; peripheral neuropathy; impairment of both humoral and cell-mediated immunity, i.e., spleen and thymic atrophy, reductions in peripheral lymphocyte levels and decreased response to mitogens (Willis-Carr and St. Pierre, 1978;Axelrod, 1981;Gridley et al, 1987;Doke et al, 1998;Ladipo, 2000); development of microcytic anemia (Chandra, 1983;Ha et al, 1984;Gridley et al, 1987;Rall and Meydani, 1993;Frydas et al, 1999;Ronnenberg et al, 2000); and, increased tendency to develop infections (Rall and Meydani 1993;Holman, 1995). Studies on pyridoxine supplementation to improve pyridoxine-deficient status and to mitigate or repair toxicities associated with the deficient state have been reported (Cassel et al, 1978;Kwak et al, 2002;Chiang et al, 2005;Oshiro et al, 2005;Wolters et al, 2005).…”