Effect of Moxibustion on HIF-1<i>α</i> and VEGF Levels in Patients with Rheumatoid Arthritis

Gong, Yuanyuan; Yu, Zeyun; Wang, Yingni; Xiong, Yan; Zhou, Yumei; Liao, Chenxi; Li, Yuan; Luo, Yun; Bai, Yu; Chen, Bailu; Tang, Yuyan; Wu, Ping

doi:10.1155/2019/4705247

Cited by 30 publications

(27 citation statements)

References 26 publications

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“…Most of the studies on the efficacy and mechanism of moxibustion are laboratory studies, and there are relatively few studies on clinical mechanism. Therefore, we have begun to study the clinical mechanism in recent years [ 21 , 22 ]; this research chooses MMP-1, MMP-3, and VEGF as the research objects, which is helpful to further reveal the effective mechanism of moxibustion in the treatment of RA.…”

Section: Discussionmentioning

confidence: 99%

“…ST36 and BL23 are commonly used for acupuncture and moxibustion in the treatment of RA. Our previous basic researches and clinical studies have shown that moxibustion at ST36, BL23, and Ashi points can significantly improve the clinical symptoms of RA patients, and its mechanism may be related to the regulation of cytokines and signal pathways, such as IL-1 β , TNF- α , HIF-1 α , and NF- kB [ 22 , 23 ]. Besides, some studies have confirmed that moxibustion at ST36 and BL23 could improve synovitis by regulating the RANKL/OPG signaling pathway and IL-17 [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which will eventually lead to joints deformity and functional damage. The aim of this research is to evaluate the effect of moxibustion on the serum indicators related to bone and cartilage metabolism, matrix metalloproteinase 1 (MMP-1), matrix metalloproteinase 3 (MMP-3), and vascular endothelial growth factor (VEGF) in patients with RA and to explore the mechanism of moxibustion in the treatment of RA. Methods. We recruited 70 RA patients who met the inclusion criteria, and they were randomly divided into two groups, a treatment group and a control group in equal ratio. The control group took methotrexate, folate, or leflunomide orally, while the treatment group received methotrexate, folate, or leflunomide orally and moxibustion at ST36 (Zusanli), BL23 (Shen shu), and Ashi points. We compared the clinical symptoms, RA serological disease markers and serum contents of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), MMP-1, MMP-3, and VEGF of RA patients before and after treatment. Results. (1) The clinical symptoms and RA serological disease markers of the two groups improved after treatment (P < 0.05), while the clinical symptoms of the treatment group were significantly improved in comparison with the control group (P < 0.05). (2) The levels of IL-1β, TNF-α, and VEGF decreased in both groups after treatment (P < 0.05), but the treatment group was significantly decreased compared with the control group (P < 0.05). (3) There were significant differences in MMP-1 and MMP-3 contents after treatment in the treatment group (P < 0.05, P < 0.05), while there were no significant differences in the control group (P > 0.05, P > 0.05). Above all, the contents of IL-1β, TNF-α, MMP-1, MMP-3, and VEGF in the treatment group decreased more significantly than those in the control group (P < 0.05). Conclusion. The improvement effect of moxibustion on the clinical symptoms of RA patients may be related to influence on the contents of IL-1β, TNF-α, MMP-1, MMP-3, and VEGF, and moxibustion may play a potential role in bone protection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…This meta-analysis indicated that moxibustion has certain effects on the amelioration of the inflammation in animal models with RA, including the downregulation of the level of proinflammatory cytokines and the upregulation of the level of anti-inflammatory cytokines at the same time. Clinical trials revealed that moxibustion can enhance the anti-inflammatory and analgesic effects of conventional medicine and downregulate HIF-1 α /VEGF contents to inhibit angiogenesis [ 33 ]. The conclusion is similar to the previous clinical meta-analysis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion on Inflammatory Cytokines in Animals with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Zhong

Cheng

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. This study aims to systematically evaluate the effect of moxibustion on the level of inflammatory cytokines in animal models with rheumatoid arthritis (RA) and to provide evidence for the clinical application of moxibustion to the treatment of RA and related basic researches. Methods. The databases employed in this study include PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), SinoMed, and Wanfang Data Information Site. The retrieval time was from the establishment of these databases to March 2020. The reviewers made use of the CAMARADES 10-item checklist to evaluate the quality of each included study. The inflammatory cytokines were considered as the outcome measure. The Revman 5.3 software was used to conduct meta-analysis on the outcome indicators of the studies included. Results. A total of 648 articles were retrieved and 18 animal experiments were included in this study. The quality scores of the studies ranged from two to eight with a mean of 5.8. Compared with the effect of the control group, moxibustion reduced the expression of TNF-α (SMD 2.95, 95% CI: 1.99–3.92, P<0.00001), IL-1β (SMD 4.10, 95% CI: 2.37–5.84, P<0.00001), IFN-γ (MD 25, 95% CI: 16.17–33.82, P<0.00001), IL-6 (MD 11.83, 95% CI: 6.22–17.44, P<0.0001), and IL-17 (MD 99.3, 95% CI: 86.83–111.76, P<0.00001). At the same time, the level of IL-2 (SMD 8.89, 95% CI: 0.93–16.86, P=0.03), IL-4 (MD 1.79, 95% CI: 0.26–3.32, P=0.02), and IL-10 (MD 5.93, 95% CI: 1.37–10.49, P=0.01) increased after moxibustion treatment. Asymmetric funnel plots indicated that there was publication bias. Conclusion. The findings of the present review indicate that moxibustion can protect the synovium of joint in animal models with RA by upregulation of the level of anti-inflammatory cytokines and downregulation of the level of proinflammatory cytokines. Moxibustion has the potential to relieve inflammation of RA.

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“…The signi cant effects of moxibustion on pain in patients with RA have been reported in various conclusions, but the effects on in ammatory factors in RA were unclear. Moxibustion enhanced the analgesic effects and anti-in ammatory of traditional and can enhance the effect of traditional medicine, reduce HIF-1α/VEGF contents to inhibit angiogenesis [18] .…”

Section: Description Of the Interventionmentioning

confidence: 99%

The Effectiveness of Acupuncture and Moxibustion for Rheumatoid Arthritis: A Protocol of an Overview of Systematic Reviews and Meta-analysis

Tang

Xiong²,

Zhu

et al. 2020

Preprint

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Background: Rheumatoid Arthritis(RA) is a common chronic disease with an annual incidence of 25 per 10000 of the population, which will result in severe joint damage,disability and death. It is strongly supported by systematic reviews (SRs) as part of the treatment of these patients. However, the evidence has not been methodically integrated. This overview aims to describe,synthesize,evaluate the reliability of evidence come from current systematic reviews of acupuncture and moxibustion therapy for RA.Methods: We will search for SRs and meta-analyses from Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PubMed, MEDLINE, Wan-Fang Databases,China National Knowledge Infrastructure (CNKI), Citation Information by National Institute of Informatics, Chinese Biomedical Literature Database(CBM),Chinese Scientific Journal Database(VIP Database). Additionally, we will search for the ongoing, unpublished, or recently completed SRs on the PROSPERO database. Two reviewers will assess those SRs, select data independently. Any disagreement will be resolved through discussion or arbitrated by the third author if necessary. The overview of SRs and meta-analysis will be reportedaccording to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA)statement.Results: The results in this study will be published in a peer-reviewed journal.Conclusion: The conclusion of our study expects to provide extensive evidence from multiple meta-analysis and systematic reviews for patients with RA.INPLASY registration number:INPLASY202080031.

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Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis

Cited by 30 publications

References 26 publications

Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis

Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis

Effect of Moxibustion on Inflammatory Cytokines in Animals with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

The Effectiveness of Acupuncture and Moxibustion for Rheumatoid Arthritis: A Protocol of an Overview of Systematic Reviews and Meta-analysis

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