Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats

Karadi, R. V.; Gadge, Navneet B.; Alagawadi, K. R.; Savadi, R. V.

doi:10.1016/j.jep.2005.11.004

Cited by 195 publications

(167 citation statements)

References 22 publications

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“…Stone formation in ethylene glycol fed is caused by hyperoxaluria, which causes increased renal retention and excretion of oxalate [26] . Renal calcium oxalate deposition by ethylene glycol 0.75% v/v for 28 days in rats is frequently used to mimic the urinary stone formation in humans [17,27] . Urinary volume is markedly increased in experimental groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antiurolithiatic Effect of Pedalium murex Fruit Extract in Ethylene Glycol-induced Nephrolithiasis in Rat

Patel¹,

Vyas²

2016

ijps

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Patel, et al.: Antiurolithiatic activity of P. murexThe aim of present investigation was to evaluate the effect of Pedalium murex fruit extract in ethylene glycolinduced urolithiasis in male rats. Nephrolithiasis was induced in male Wistar rats by adding ethylene glycol (0.75%) in drinking water for 28 days. Animals divided in six groups each containing six animals. Vehicle control, model control, P. murex methanol extract in different doses 100, 200 and 400 mg/kg p.o. cystone (750 mg/kg, p.o.) used as standard. Hyperoxaluria as well as the increase in the excretion of calcium, phosphate, uric acid and decrease in citrate and magnesium in urine, impairment of renal function and oxidative imbalance in kidney observed in calculi-induced group. Treatment with P. murex decreases hyperoxaluria, calcium, uric acid, improves renal function and also produces antioxidant effect. Crystalluria was characterized by excretion of large calcium oxalate crystals in lithogenic group but smaller in drug-treated group. The histology showed depositions of large number of calcium oxalate crystals in kidney in calculi-induced group while in the treated group small and fewer deposits. The result indicates antiurolithiatic activity of P. murex mediated possibly by calcium oxalate crystal inhibition, diuretic, antioxidant and maintaining bal ance between stone promoters and inhibitors constituents and this study rationalized its medicinal use in urolithiasis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antiurolithiatic Effect of Pedalium murex Fruit Extract in Ethylene Glycol-induced Nephrolithiasis in Rat

Patel¹,

Vyas²

2016

ijps

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“…Impairment of renal functions of untreated rats is evident from the markers of glomerular and tubular damage: raised BUN serum creatinine and reduced creatinine clearance (Karadi et al, 2006). Renal dysfunction diminishes the ability to filter urea and creatinine clearance, so the BUN and creatinine level rises in blood (Cao et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Pareta

Patra

Mazumder

et al. 2011

Pharmaceutical Biology

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“…and group VII received fraction III (40 mg/kg b.w) from 14th day to 28th day. 4,5 The Phytochemical screening of the extract and fractions II and III showed mainly the presence of flavanoids, Saponins, Triterpenoids, glycosides, steroids and phenolic compounds. (Figure 1) No crystal deposition was found in normal group animals.…”

Section: Isolationmentioning

confidence: 99%

In silico Antiurolithiatic Screening of Aerva lanata (L) Isolated constituents

Dinnimath¹,

Jalalpure²

2015

IJPER

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Background: Traditionally known as Pashanabheda in India, Aerva lanata (L) belonging to the family Amaranthaceae, is widely available in Western ghats of India and used as Antiurolithiatic, astringent, diuretic, antimicrobial, antiinflammatory, hepatoprotective drug by Indian traditional system of medicines. Materials and Method: In the present study this herb is subjected to extraction with hydro alcohol followed by fractionation with different solvents of varying polarities such as dichloromethane, ethyl acetate and n-butanol and screened for Antiurolithiatic activity using ethylene glycol induced male Wistar albino rats. Based on the results, the potent fractions were subjected to isolation of active constituents using column chromatography. Results: The isolated compounds from two fractions n-butanol and ethyl acetate were characterized by modern analytical techniques such as IR, HPTLC, NMR and LCMS as Quercetin and Betulin. Later these two compounds were studied for Antiurolithiatic activity by In silico technique by docking with a protein 2 ETE of Oxalate oxidase from PDB and the results indicated better regio-specificity with the enzyme. Conclusion: The two compounds isolated from potent fractions based on bioactivity guided fractionation were characterized as Quercetin and Betulin by modern analytical techniques. These two compounds were studied by in silico method and these two compounds have produced significant results which substantiate their claim of bioactivity. However in vivo study is needed to confirm the activity.

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Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats

Cited by 195 publications

References 22 publications

Evaluation of Antiurolithiatic Effect of Pedalium murex Fruit Extract in Ethylene Glycol-induced Nephrolithiasis in Rat

Evaluation of Antiurolithiatic Effect of Pedalium murex Fruit Extract in Ethylene Glycol-induced Nephrolithiasis in Rat

Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

In silico Antiurolithiatic Screening of Aerva lanata (L) Isolated constituents

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