Aqueous extract of<i>Boerhaavia diffusa</i>root ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Pareta, Surendra K.; Patra, Kartik Chandra; Mazumder, Papiya Mitra; Sasmal, D.

doi:10.3109/13880209.2011.581671

Cited by 30 publications

(19 citation statements)

References 40 publications

(41 reference statements)

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“…Our developed polyherbal combination does ameliorate oxidative markers. Previous reports of reduction in the oxidative markers with B. diffusa (Pareta et al 2011b), R. emodi (Chang and Kim 2018), N. nucifera (Krishnamoorthy et al 2009) and C. nurvala (Shirwaikar et al 2004) are in line with the current findings. The antioxidant effect of the constituent ingredients seems to contribute to the overall nephroprotective action of the polyherbal combination.…”

Section: Discussionsupporting

confidence: 93%

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Sharma

Baboota

Amin

et al. 2020

Pharmaceutical Biology

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Context: Nephrotoxicity is a renal dysfunction that arises from direct exposure to environmental chemicals or as a side effect of therapeutic drugs. Boerhaavia diffusa Linn. (Nyctaginaceae), Rheum emodi Wall. Ex. Meissn. (Polygonaceae), Nelumbo nucifera Gaertn. (Nelumbonaceae) and Crataeva nurvala Buch-Ham. (Capparidaceae) are well-recognized medicinal plants of Indian traditional system of medicine used for kidney disorders.Objectives: The present investigation was undertaken to develop a chromatographically characterized polyherbal combination and to evaluate its nephroprotective activity. Materials and methods: Roots of B. diffusa and R. emodi, flowers of N. nucifera and stem bark of C. nurvala were extracted by decoction using 70% ethanol. Response surface methodology (RSM) was used for the optimization of extraction parameters. Polyherbal combinations with different doses (150-300 mg/kg) were tested against methotrexate-induced nephrotoxicity in Wistar rats. Results: The optimized extract contained 27% phenols and 15% flavonoids, which showed 75% 1, 1diphenyl-2-picryl-hydrazyl (DPPH) scavenging potential. Based on the retention time of high-performance liquid chromatography (HPLC) analysis, 17 out of 122 constituents were found common in all extracts and combinations. Two combinations showed significantly higher (p 0.05) DPPH scavenging potential and xanthine oxidase inhibition. The half maximal inhibitory concentration (IC 50 ) of the best combination for DPPH scavenging and xanthine oxidase inhibition were 80 and 74 mg/mL, respectively. Treatment of methotrexate-induced nephrotoxic rats with polyherbal combination significantly (p 0.05) improved the kidney function markers, oxidative stress markers and histological parameters. Discussion and conclusion: The developed combination was found to be effective in nephrotoxicity; it can be explored further for the management of drug-induced nephrotoxicity and other chronic kidney diseases. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 93%

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Sharma

Baboota

Amin

et al. 2020

Pharmaceutical Biology

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“…It is known that B. diffusa L. has been used ethnopharmacologically as a single or combination treatment with other plants for curing scorpion and snake bites, hepatitis, and nephritis, which are representative inflammatory symptoms induced by various inflammatory mediators (Mishra et al, 2014). Through additional systematic studies, the anti-inflammatory and antinociceptive activities of this plant in abdominal writhing, swelling, renal injury, and liver damage conditions have been demonstrated (Mishra et al, 2014;Mudgal, 1975;Olaleye, Akinmoladun, Ogunboye, & Akindahunsi, 2010;Pareta, Patra, Mazumder, & Sasmal, 2011). Considering these reports, the inhibitory activities ( Fig.…”

Section: Discussionmentioning

confidence: 89%

Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6

Thai

Kim

et al. 2015

Journal of Functional Foods

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“…There are several reports on the use of TCM in the management of urinary stone disease [18]; the pharmacological effects include increased urinary volume, decreased crystal formation, and decreased secretion of promoter [28]. Purportedly, TCM treatments have fewer side effects than other antilithic treatments.…”

Section: Discussionmentioning

confidence: 99%

Effect of Flos carthami Extract and α₁‐Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis

Man

Shen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis. In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/紅花) has been used to treat urological diseases for centuries. We previously performed a screening and confirmed the in vivo antilithic effect of FC extract. Here, ex vivo organ bath experiment was further performed to study the effect of FC extract on the inhibition of phenylepinephrine (PE) (10−4 and 10−3 M) ureteral peristalsis of porcine ureters with several α 1-adrenergic antagonists (doxazosin, tamsulosin, and terazosin) as experimental controls. The results showed that doxazosin, tamsulosin, and terazosin dose (approximately 4.5 × 10−6 − 4.5 × 10−1 μg/mL) dependently inhibited both 10−4 and 10−3 M PE-induced ureteral peristalsis. FC extract achieved 6.2% ± 10.1%, 21.8% ± 6.8%, and 24.0% ± 5.6% inhibitions of 10−4 M PE-induced peristalsis at doses of 5 × 103, 1 × 104, and 2 × 104 μg/mL, respectively, since FC extract was unable to completely inhibit PE-induced ureteral peristalsis, suggesting the antilithic effect of FC extract is related to mechanisms other than modulation of ureteral peristalsis.

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Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Cited by 30 publications

References 40 publications

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6

Effect of Flos carthami Extract and α₁‐Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis

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Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Cited by 30 publications

References 40 publications

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6

Effect of Flos carthami Extract and α1‐Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis

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Effect of Flos carthami Extract and α₁‐Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis