Effect of Monounsaturated Fatty Acids Versus Complex Carbohydrates on High-Density Lipoproteins in Healthy Men and Women

Mensink, R.P.; Katan, M.B.

doi:10.1016/s0140-6736(87)91965-9

Cited by 433 publications

(187 citation statements)

References 16 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…It is, therefore, imperative to identify alternative diets that can more effectively modify the plasma lipid profiles, and thus reduce CHD risk. In contrast with a Step I or Step II diet, a MUFA diet tends to raise HDL cholesterol and lower TAG concentrations (Grundy, 1986;Mensink and Katan, 1987;Rajaram et al, 2001;Hyson et al, 2002). In keeping with this evidence, hazelnut that is an excellent source of MUFA (Alasalvar et al, 2003b, c), may help in this respect.…”

Section: Introductionmentioning

confidence: 83%

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

104

View full text Add to dashboard Cite

Objective: Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function. Subjects and design: Fifteen hypercholesterolemic men aged 4878 years were recruited voluntarily. A well-controlled, 2-period (P 1 and P 2 ) study design with a total of 8-week was implemented. In the P 1 , subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P 2 , the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period. Results: Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (Po0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (Po0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets. Conclusions: This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile. Sponsorship:

show abstract

Section: Introductionmentioning

confidence: 83%

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

104

View full text Add to dashboard Cite

show abstract

“…In modern experiments Mensink & Katan (1987) con®rmed Keys' classic result. When 20% of energy as carbohydrates was replaced by olive oil there was no difference in plasma total cholesterol.…”

mentioning

confidence: 83%

“…They did not publish a regression equation. Surprisingly they do not appear to have been aware of the meta-analysis by Mensink & Katan (1987) three years earlier in the same journal.…”

mentioning

confidence: 99%

Monounsaturated oils do not all have the same effect on plasma cholesterol

Choudhury

1998

Eur J Clin Nutr

View full text Add to dashboard Cite

Evidence assembled here indicates that when olive oil forms a major part of dietary fat in controlled human experiments, total and LDL-cholesterols are somewhat higher than when the same amount of fat is one of the modern predominantly monounsaturated oils: low erucic rapeseed or high oleic sun¯ower oil. Oils rich in monounsaturated fatty acids thus do not all have the same effect on plasma cholesterol. This phenomenon is explicable by consideration of the content of other fatty acids and the non-saponi®able fractions of the different monounsaturated oils. It helps to explain the discrepancy that has existed between the classic experiments (using olive oil), which found monounsaturated oils`neutral', and some of the more recent experiments which found them more cholesterol-lowering than carbohydrates. Four published meta-analyses are reviewed. The three which included most of the published experiments show that monounsaturated fatty acids (MUFA) have less plasma cholesterol-lowering effect than polyunsaturated fatty acids.

show abstract

“…There have been concerns that high carbohydrate intakes at the expense of fat, particularly monounsaturated fat (Coulston et al, 1989;Mensink and Katan, 1987;Garg et al, 1994) could result in a rise in triglycerides and very-lowdensity lipoproteins and a suppression of HDL levels, which could translate into a higher risk of heart disease (Gordon et al, 1989;Stampfer et al, 1996;Vega & Grundy, 1996;Hokanson & Austin, 1996). However, not all carbohydrate-rich diets may produce the same effects on HDL levels, as low-GI diets may confer a more favorable lipid profile compared with high-GI diets.…”

Section: The Glycemic Index In Coronary Heart Diseasementioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

View full text Add to dashboard Cite

Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

show abstract

Effect of Monounsaturated Fatty Acids Versus Complex Carbohydrates on High-Density Lipoproteins in Healthy Men and Women

Abstract: SummaryThe effects of two strictly controlled diets, one rich in complex carbohydrates, the other rich in olive oil, on serum lipids were studied in healthy men

Cited by 433 publications

References 16 publications

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Monounsaturated oils do not all have the same effect on plasma cholesterol

Glycemic index in chronic disease: a review

Contact Info

Product

Resources

About