Effect of Molybdenum Trioxide Nanoparticles on Ovary Function in Female Rats

Asadi, Fardin; Sadeghzadeh, Mansour; Jalilvand, Ahmad; Nedaei, Keivan; Asadi, Yasamin; Heidari, Azam

doi:10.30699/jambs.27.121.48

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…Moreover, [ 61 ] discovered that varying amounts of Ag NPs administered intraperitoneally for different periods presented a nonsignificant increase in serum progesterone. It was stated that the variation in hormonal levels could be attributed to the direct effect of NPs on the ovaries, which slowed follicular growth and decreased oestrogen, or interfered with follicle function [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic effects of dose dependent inorganic magnesium oxide nanoparticles on the reproductive organs of rats

Naguib,

Abd El-Aziz,

Kayal

et al. 2023

Annals of Medicine

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Introduction Magnesium oxide nanoparticles (MgO NPs) have a variety of applications that have contributed to their elevated popularity, however, the safety and toxic effects on humans are also of concern with these increased applications. There is insufficient data regarding the effect of MgO NPs on reproductive organs, which are crucial aspects to the body’s vital physiological functions. The present study was undertaken in male and female rats to assess the reproductive toxicological potential of two doses (low versus high) of MgO NPs on testicular and ovarian tissues. The toxicity was evaluated using histological, hormonal, and oxidative parameters. Material and Methods In this work, magnesium oxide nanoparticles (MgO NPs) were synthesized by the sol-gel route and were characterized by X ray diffraction analysis (XRD) and Fourier transform infra-red spectroscopy (FTIR). Forty-eight adult Wister albino rats were used in this experiment which were divided into groups of male and female, and then further into control, low dose MgO NPs, and high dose MgO NPs. The low dose used was 131.5 mg/kg b.w. (1/10 LD50) while the high dose used was 263 mg/kg b.w. (1/5 LD50). All doses were given orally by gastric tube. After 4 weeks, blood samples were collected to investigate the level of sex hormones and both ovarian and testicular tissues were examined for variable oxidative parameters and histopathological changes by light microscopy. Results The obtained findings showed that high dose of MgO NPs produced considerable changes in sex hormones and stress parameters in both male and female rats in comparison to the low dose and control groups. Histomorphometric analysis demonstrated the presence of histopathological alterations in the testicular and ovarian tissues. Conclusion The results of this study showed dose-dependent adverse effects of MgO NPs on the testis and ovary both functionally and histopathologically as compared to the control rats.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic effects of dose dependent inorganic magnesium oxide nanoparticles on the reproductive organs of rats

Naguib,

Abd El-Aziz,

Kayal

et al. 2023

Annals of Medicine

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“…NPs affect the reproductive system by inducing cytotoxicity in ovarian cells, thereby disrupting the process of oogenesis and eventually causing the overproduction of ROS, apoptosis, and sex-hormone imbalance in the body (Iavicoli et al, 2013). In a study, an animal administered with MoO3 showed a significant decrease in the right ovary's weight and uterine weight, which ultimately led to an adverse effect on the reproduction process (Asadi et al, 2019). Hence, NPs are significantly responsible for decreasing birth rates and causing abnormalities in offsprings.…”

Section: Effect Of Nanoparticles On the Reproductive Systemmentioning

confidence: 99%

Inhalation Exposure to Atmospheric Nanoparticles and Its Associated Impacts on Human Health: A Review

Sonwani

Madaan

Arora

et al. 2021

Front. Sustain. Cities

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Nanoparticles (NPs) are receiving an increasing attention from many scientific communities due to their strong influence on human health. NPs are an important marker of air pollution caused by a variety of natural and anthropogenic sources. Due to their ultrafine size, they can be suspended in the atmosphere for a long time and can thus travel larger distances and cause several health issues after exposure. A variety of NPs that are found in indoor and outdoor settings cause respiratory and cardiovascular diseases. Exposure to NPs through active and passive smoking and household and occupational subjection is reported with thick septum, shortness of breath, and a high level of interleukin protein and tumour necrosis factor (TNF-α) that cause tumour generation in the exposed population. This comprehensive review summarises NPs' source, exposure, and impact on different organ systems. Respiratory models (experimental and computational) used to determine the particle's deposition, airflow transport, and health impact are also discussed. Further, muco-ciliary escalation and macrophage activity, the body's clearance mechanisms after exposure to NPs, have been mentioned. An in-depth analysis of exposure to NPs through inhalation and their health impact has been provided with detailed insights about oxidative stress, inflammation, genotoxicity, and tumourigenicity. Overall, this review offers scientific evidence and background for researchers working in the field of epidemiology, biochemistry, and toxicological studies with reference to atmospheric nanoparticles.

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“…As a result, it is critical to have access to all necessary information and clarifications to assess the risks associated with the NPs 11 , 12 . According to the literature, exposure to ultrafine particles (< 100 nm) could induce tissue inflammation and pulmonary damage, lung tumors, and fibrosis 13 . However, the generation of reactive oxygen species (ROS) is mainly associated with the toxicity of NPs.…”

Section: Introductionmentioning

confidence: 99%

The effect of exposure to MoO3-NP and common bean fertilized by MoO3-NPs on biochemical, hematological, and histopathological parameters in rats

Shaban

Salama

El‐Aziz

et al. 2022

Sci Rep

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Nanotechnologies has been used to introduce several beneficial tools in the agricultural field. Herein, the effect of molybdenum oxide nanoparticles (MoO3-NPs) was investigated by evaluating the hematological, biochemical, and histopathological parameters in rats orally exposed to MoO3-NPs or fed common beans (CB) fertilized by MoO3-NPs. In the first study, 18 rats were randomly divided into 3 groups: G1 (control group) was given water orally, while G2 and G3 were administered 10 and 40 ppm MoO3-NPs by oral gavage tube, respectively. There was a significant increase in the levels of alanine aminotransferase (ALT), albumin, and total protein; however, there was a a significant decrease in body weight change (BWC), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine, creatine kinase–MB (CK-MB), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and testosterone levels in G3 compared to G1. In the second study, 24 rats were divided into 4 groups: the control (C) group was fed a balanced diet, and three groups were fed on a balanced diet plus 10% CB that was fertilized with 0, 10, and 40 ppm MoO3-NPs, resulting in nCB, CB10, and CB40 groups, respectively. This revealed a significant increase in BWC and total food intake (TFI) but a significant decrease in relative kidney weight in all the CB groups compared to the control group. In CB10 and CB40 groups ALT, LDH, TSH, FT3, and testosterone levels were significantly lower than the respective levels in the control group. We concluded that high doses of MoO3-NPs caused more side effects than low doses in both experiments.

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Effect of Molybdenum Trioxide Nanoparticles on Ovary Function in Female Rats

Cited by 7 publications

References 30 publications

Cytotoxic effects of dose dependent inorganic magnesium oxide nanoparticles on the reproductive organs of rats

Cytotoxic effects of dose dependent inorganic magnesium oxide nanoparticles on the reproductive organs of rats

Inhalation Exposure to Atmospheric Nanoparticles and Its Associated Impacts on Human Health: A Review

The effect of exposure to MoO3-NP and common bean fertilized by MoO3-NPs on biochemical, hematological, and histopathological parameters in rats

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