Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in Gastrocnemius Muscle

Fujita, Ryo; Tanaka, Yoshinori; Saihara, Yasuhiro; Yamakita, Mitsuya; Ando, Daisuke; Koyama, Katsuhiro

doi:10.2114/jpa2.30.195

Cited by 27 publications

(17 citation statements)

References 29 publications

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“…It has been well established that hydrogen-rich water has beneficial effects on different disease models and is mostly dependent on its anti-inflammation, 48) and antioxidative properties. 49) Hydrogen molecules also rapidly diffuse into tissues and cells and it is mild enough to disturb cellular processes. Our conjecture is that the ameliorating effect of ARW in obese mice model at least partially attributable to the existence of the dissolved hydrogen in the ARW.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.Key words alkaline reduced water; adiponectin; cytokine; adiposity; epididymal fat; cholesterol 7α-hydroxylase Obesity has reached global epidemic status. In developed and developing countries, obesity is reported to be the sixth most important risk factor contributing to the overall burden of chronic disease.1) Forty three million children, 82% of which from developing countries, are affected with obesity.2)The World Health Organization recently reported that there were more than 1 billion overweight adults worldwide, of whom 500 million were obese.3) Obesity poses a major public health issue as it is known to be positively associated with increased risk of certain chronic diseases such as cardiovascular disease, hypertension, type 2 diabetes and fatty liver. [3][4][5] Excessive intake of dietary fats influences the progression of obesity, 6) which is characterized by accumulation of body fats marked by abnormal increase in adipose tissue mass and liver fats (adiposity), dysregulated levels of adipokines, and imbalance between pro-and anti-inflammatory cytokine. 7-9)The complexity of these pathogenetic mechanisms of obesity poses a challenge to the development of effective therapy. In that context, there has been growing concern for the need of newer therapeutic strategies that directly deal with these mechanisms. Of several such candidates, we first introduced the alkaline reduced water (ARW) for obesity control in highfat (HF) diet-induced obesity (DIO) in mice model. ARW refers to electrolyzed water produced from minerals such as magnesium and calcium, which is characterized by supersaturated hydrogen, high pH, and a negative oxidation reduction potential. This hydrogen-rich functional water has been introduced as a feasible therapeutic strategy for health promotion and disease prevention. [10][11][12] Our previous studies ...

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Section: Discussionmentioning

confidence: 99%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Being prompted by the prominent effects of H 2 on disuse muscle atrophy, cartilage trauma, and osteopenia in animal studies 11– 13 , a number of clinical investigators from 2010 onwards evaluated the effectiveness of H 2 in patients suffering from different muscle and bone ailments – from sprains and strains to chronic joint disorders to myopathies 7– 9 . Typically, these studies were designed as single-blind pilot trials, with small sample sizes (< 40 participants) and of short duration (≤ 12 weeks).…”

Section: Promising Results From Preliminary Studiesmentioning

confidence: 99%

Should hydrogen therapy be included in a musculoskeletal medicine routine?

Ostojić

2016

F1000Res

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Molecular hydrogen (H 2) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H 2 improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this paper, the medicinal properties of H 2 in musculoskeletal medicine are discussed with the aim to provide an updated and practical overview for health professionals working in this field.

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“…Drinking enriched water ad libitum ameliorated disuse muscular atrophy after paralysis in rats [58] and protected against cardiac and kidney fibrosis by ischemic/reperfusion of kidney [59] and aging [83] in Dahl SS rats. Furthermore, chronic ad libitum drinking could reduce lipopolysaccharide-induced neuroinflammation by downregulation of TNF-α and upregulation of IL-10 in the brain, to promote recovery from sickness behavior in mice [84].…”

Section: The Hydrogen Gas Molecule As a Biological Antioxidantmentioning

confidence: 96%

“…Effects of H 2 as an antioxidant and anti-inflammatory molecule are summarized. Accumulating evidence from animal studies has revealed that H 2 is a biologically active gas, increasing antioxidative molecules, while decreasing oxidative markers, pro-inflammatory molecules, and apoptosis in affected organs and tissues possible to deliver water having 0.3-0.5 mg/L using presently available commercial electrolysis equipment [58,59]. Shirahata et al [76] and, furthermore, of hydrogen peroxide (H 2 O 2 ) are lower when compared with control water.…”

Section: The Hydrogen Gas Molecule As a Biological Antioxidantmentioning

confidence: 99%

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

2016

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Increased oxidative stress and pro-inflammatory conditions, commonly present in chronic dialysis patients, are thought to be enhanced during hemodialysis (HD) and to be associated with the excess morbidity and mortality seen in these patients. The hydrogen molecule (H 2 ) has a unique biological capacity to act as an antioxidative and anti-inflammatory substance. In light of accumulating evidence from animal studies showing protective effects against organ damage during ischemia and inflammation, development of H 2 treatments for HD patients has become a challenging clinical goal. An HD system utilizing a water electrolysis technique that renders large amounts of H 2 -enriched water has been developed. During HD with an H 2 -enriched solution (approximately 50 ppb H 2 ), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed. These findings indicate that the use of an H 2 -enriched solution may prove to be a novel approach to ameliorate dialysis-related complications. This manuscript reviews the recent progress in H 2 research and the use of H 2 in HD patients, including a description of a water electrolysis technique that delivers large amounts of H 2 -enriched water for use in clinical settings.

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Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in Gastrocnemius Muscle

Cited by 27 publications

References 29 publications

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Should hydrogen therapy be included in a musculoskeletal medicine routine?

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

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