Effect of moderate maternal malnutrition on the placenta

Lechtig, A; Yarbrough, Charles; Delgado, Hernán; Martorell, Reynaldo; Klein, Robert E.; Behar, Moisés

doi:10.1016/0002-9378(75)90526-8

Cited by 57 publications

(21 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that severe anemia, present from early gestation along with concomitant maternal malnutrition, may be associated with reduced placental weight 31,32 and structural abnormalities of the placenta. 25 Placental size is closely related to the surface area of peripheral villi, 33 which, in turn, determines the transport of nutrients across the placenta. 34 In the present study there was no significant difference in the placental size between anemic and nonanemic control mothers.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Kumar¹,

Kumar²,

Basu³

et al. 2008

Pediatrics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Kumar¹,

Kumar²,

Basu³

et al. 2008

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Maternal nutritional deficiencies of protein, folic acid, vitamin A,B,C, zinc, calcium, magnesium, copper or selenium may all lead to IUGR [155][156][157][158][159]. Among the many reasons for malnutrition, anorexia nervosa is associated with IUGR [160] and in an Australian study 30% of women with babies less than 2500 g suffered from eating disorders [161].…”

Section: Metabolic and Nutritional Factors Pre-pregnancy Weight And mentioning

confidence: 99%

Growth Restriction: Etiology, Maternal and Neonatal Outcome. A Review

Haram¹,

Svendsen²,

Myking

2007

CWHR

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) is an important clinical problem associated with increased perinatal mortality and morbidity. The most preferred small for gestational age (SGA) definition is birth weight below the 10th percentile, adjusted for gestational age. The incidence of IUGR is about 4 to 7 %. A variety of hormones are involved. IUGR may be due to chromosomal defects, smoking, early-onset preeclampsia (< 34 weeks), connective tissue and inflammatory rheumatic diseases, maternal infections, several drugs, twin-to twin transfusion, anorexia nervosa, low maternal pre-pregnancy or small weight gain during pregnancy. High hemoglobin (Hb) levels during the first 10-20 weeks of pregnancy may also cause IUGR. Complications due to IUGR include fetal or neonatal death, dysmaturity, and physical as well as temporary or permanent mental defects. Low birth weight children may have behavioral problems, psychiatric disorders and lower intelligence test scores later in life. There is a relationship between IUGR, timing and progression of puberty, and polycystic ovary syndrome. Fetal changes of lipid metabolism and homeostasis in IUGR may place the grown adult at risk for hypertension, diabetes mellitus and coronary artery disease. Mothers of low weight offspring have an increased risk for cardiovascular and kidney disease later in life.

show abstract

“…The direct comparison of these two correlations suggests that placental weight might better reflect the exchange capacity of placental villi. That the surface of the placental villi seems to be the major determinant of neonatal weight was well reflected by high correlation coefficients between these two variables, ranging between 0.8 and 0.9 [8][9][10][11] . However, the surface of the placental villi and microvilli does not increase proportionally to fetal weight.…”

Section: Discussionmentioning

confidence: 93%

Do Macromorphological Features of the Human Placenta Influence Somatic and Psychomotor Development of the Newborn and Early Infant? A Historic Question Revisited

Westhof

Deerberg

Schad³

et al. 2010

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objective: We examined the meaning of placental weight, form (massive and thick or extended and flat) and circumference for early somatic and psychomotor childhood development. Methods:In this prospective study, fresh placentas (n = 265) were measured for weight and circumference and correlated with neonatal data. A subset of placentas statistically defined as ‘massive’ (circumference <10th percentile) and ‘extended’ (circumference >90th percentile) was correlated with somatic and basic psychomotor variables during the first 4 years of life. A ‘medium’ category (circumference 45–55th percentile) served as control. Results: Placental weight correlated with birth weight (r = 0.53, p < 0.0005) and mean infantile weight until month 48 (r = 0.29, p = 0.016). Placental circumference weakly correlated with birth weight (r = 0.17, p = 0.011) but not with mean infantile weight. Placental extremes (massive, medium, extended) demonstrated significant influences only on very early somatic growth (day 1 to month 4): Massive placentas were associated with heavier and taller children (p = 0.02–0.033). Markers of early psychomotor development (first sitting, crawling, running, one- and two-word sentences) were not related with placental weight or circumference nor with extremes of placental morphology. Conclusion: Placental weight and circumference seem to influence very early somatic but not psychomotor development.

show abstract

Effect of moderate maternal malnutrition on the placenta

Cited by 57 publications

References 5 publications

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Growth Restriction: Etiology, Maternal and Neonatal Outcome. A Review

Do Macromorphological Features of the Human Placenta Influence Somatic and Psychomotor Development of the Newborn and Early Infant? A Historic Question Revisited

Contact Info

Product

Resources

About