Effect of moderate dose of alcohol with evening meal on fibrinolytic factors

Hendriks, H.; Veenstra, J.; Wierik, E.J.M. Velthuis-te; Schaafsma, G.; Kluft, C.

doi:10.1136/bmj.308.6935.1003

Cited by 239 publications

(123 citation statements)

References 14 publications

(9 reference statements)

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“…Similarly, a short-term alcohol intake (Hendriks et al, 1994;Johansen et al, 1999) or consumption for longer periods (Dimmitt et al, 1998), also increased plasma tPA Ag in healthy subjects. Our data are consistent with those ®ndings, which were interpreted as potentially bene®cial in the context of CV risk.…”

Section: Effects Of Mediterranean Diet D Mezzano Et Almentioning

confidence: 85%

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

et al. 2001

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Objectives:To compare the effect of alcohol-free Mediterranean-type diet (MD) and high-fat diet (HFD) on plasma concentration of emergent haemostatic cardiovascular risk factors (HCVRF). Also, to test if red wine supplementation modi®es HCVRF, independent of diet. Design, subjects and intervention: Controlled prospective intervention study. Two groups, each of 21 healthy male university students (22 AE 3.4 y), received either MD or HFD for 90 days. Between days 30 and 60, both diets were supplemented with 240 mladay of red wine. Baseline and T30, T60 and T90-day samples were drawn. No drop out from the study was observed. Setting: University campus and outpatient nutrition clinic. Results: Volunteers on HFD at T30 had increases in pro-coagulants ®brinogen (22%), factor VIIc (9%), and factor VIIIc (4%), and decreases in natural anticoagulants antithrombin III (3%), protein C (11%) and protein S (6%) and of 20% in plasminogen activator inhibitor-1. At the same time, individuals on MD had increases in ®brinogen (4%), antithrombin III (5%), protein C (3%), protein S (2.7%), and decreases in factor VIIIc (9%), and plasminogen activator inhibitor-1 (21%). After adjusting by baseline values, MD was associated with lower plasma ®brinogen (P 0.03), factor VIIc (P 0.034) and factor VIIIc (P 0.0057) and with higher levels of protein S (P 0.013). Red wine supplementation, in both diets, resulted in decreased plasma ®brinogen (P 0.001) and factor VIIc (P 0.05), and increased tissue plasminogen activator antigen (P 0.01) and plasminogen activator inhibitor-1 antigen (P 0.0003). Wine consumption was also associated with signi®cantly (P 0.01) divergent effects on antithrombin III: it decreased by 10% in individuals on HFD but increased slightly in those on MD. No effects of diet or wine were detected in plasma protein C and C-reactive protein.Conclusion: MD and moderate consumption of red wine have complementary, mostly bene®cial effects on HCVRF.

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Section: Effects Of Mediterranean Diet D Mezzano Et Almentioning

confidence: 85%

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

et al. 2001

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“…Binge drinking has been associated with a higher pressor effect (Moreira et al, 1998;Rakic et al, 1998), although this effect appears to be timedependent. Consumption of wine with the evening meal has also been associated with an increase in plasminogen activator activity early in the next morning (Hendricks et al, 1994;Muller & Fugelsang, 1994). Further, in Northern Ireland, alcohol is mostly consumed outside meals, whereas in France it is mostly consumed with meals, and it has been shown that the pharmacological effect of ethanol can be in¯uenced by meals (Jones et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Although some authors have found that the protective effect of wine is superior to that of other alcoholic beverages (Rosenberg et al, 1981;Renaud & De Lorgeril, 1992;Goldberg, 1995), those results have not been con®rmed in other studies (Hennekens et al, 1979;Marques-Vidal et al, 1995). The mechanisms by which moderate alcoholic beverages consumption decreases coronary artery disease include the increase of high density lipoprotein levels (Gaziano et al, 1993;Marques-Vidal et al, 1995;Parker et al, 1996;Paunio et al, 1996), the modi®cation of hemostatic parameters (Sumi et al, 1988;Owens et al, 1990;Hendricks et al, 1994;Pellegrini et al, 1996) and the inhibition of lipoprotein oxidation by phenolic components present in red wine (Anonymous, 1993;Frankel et al, 1993;Kinsella et al, 1993;Sera®ni et al, 1994;Me Ârillon et al, 1997). However, although there is de®nitely a biological effect of alcohol, differences in consumption patterns and in lifestyle can also partly account for the relationship between alcohol consumption and coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

Patterns of alcohol consumption in middle-aged men from France and Northern Ireland. The PRIME Study

Marques‐Vidal

Arveiler

et al. 2000

Eur J Clin Nutr

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Objective: To assess the patterns of alcohol consumption in France and Northern Ireland. Design: Four cross-sectional studies. Setting: Sample of 50 ± 59 y old men living in France and Northern Ireland, consuming at least one unit of alcoholic beverage per week. Subjects: 5363 subjects from France and 1367 from Northern Ireland. Interventions: None. Results: Consumption of wine was higher in France whereas consumption of beer and spirits was higher in Northern Ireland. Alcohol drinking was rather homogeneous throughout the week in France, whereas Fridays and Saturdays accounted for 60% of total alcohol consumption in Northern Ireland. In both countries, current smokers had a higher consumption of all types of alcoholic beverages than non-smokers. Similarly, obese and hypertensive subjects had a higher total alcohol consumption than non-obese or normotensive subjects, but the type of alcoholic beverages differed between countries. In Northern Ireland, subjects which reported some physical activity consumed signi®cantly less alcoholic beverages than sedentary subjects, whereas no differences were found in France. Conversely, subjects with dyslipidemia consumed more alcoholic beverages than

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“…Smoking is associated with increased levels of procoagulative factors, e.g. fibrinogen [35] and reduced fibrinolytic capacity [36], while moderate alcohol consumption has been shown to influence the levels of fibrinolytic factors [37][38][39]. In fact haemostatic factors have been suggested to be on the eventual pathway to the protective effect of alcohol.…”

Section: Discussionmentioning

confidence: 99%

Alcohol and coronary heart disease: the roles of HDL‐cholesterol and smoking

Mänttäri

Tenkanen²,

Alikoski³

et al. 1997

Journal of Internal Medicine

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Abstract. Man$ tta$ ri M, Tenkanen L, Alikoski T, Manninen V (Department of Medicine, Helsinki University and Helsinki Heart Study, Helsinki, Finland). Alcohol and coronary heart disease : the roles of HDL-cholesterol and smoking. J. Intern Med 1997 ; 241 : 157-63. Objectives.To study the role of HDL-cholesterol (HDLc) in the causal pathway mediating the effect of alcohol on coronary heart disease (CHD). Design. Cox proportional hazard models were used to compare the relative CHD risks in various HDLcsmoking categories. Setting. A prospective, multicentre, placebocontrolled, double-blind CHD primary prevention trial with gemfibrozil in primary (occupational) health care units, the Helsinki Heart Study. Subjects. Dyslipidaemic middle-aged men with available alcohol consumption data (1924 of 2035) in the placebo arm of the 5-year study. Main outcome measures. Seventy-seven (of 84) cases of nonfatal myocardial infarction or cardiac death.

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Effect of moderate dose of alcohol with evening meal on fibrinolytic factors

Cited by 239 publications

References 14 publications

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

Patterns of alcohol consumption in middle-aged men from France and Northern Ireland. The PRIME Study

Alcohol and coronary heart disease: the roles of HDL‐cholesterol and smoking

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