Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters

Atsdr Evaluation of Health Effects of Chemicals

“…The adaptive effects observed are those generally produced by halogenated hydrocarbons; these include increase in liver weight or size (Gaines and Kimbrough, 1970;Mehendale et al, 1973;Abston and Yarbrough, 1976;Davison et al, 1976;Chadwick et al, 1977;Fulfs et al, 1977;Villeneuve et al, 1977;Robinson and Yarbrough, 1978a,c;Warren et al, 1978;Hewitt et al, 1979;Larson et al, 1979a;Pittz et al, 1979;Chu et al, 1980bChu et al, , 1981aMehendale, 1981b;Robacker et al, 1981;Yarbrough et al, 1981Yarbrough et al, , 1984Yarbrough et al, , 1986aYarbrough et al, ,b, 1992Ritchie and Ho, 1982;Chambers and Trevethan, 1983;Ervin and Yarbrough, 1983;Fujimori et al, 1983;Williams and Yarbrough, 1983;Curtis and Hoyt, 1984;Karl and Yarbrough, 1984;Jovanovich et al, 1987;Plaa et al, 1987;Purushotham et al, 1988;Wilson and Yarbrough, 1988;Elgin et al, 1990;Teo and Vore, 1991;Thottassery and Yarbrough, 1991 ). Other effects observed include hepatocellular hypertrophy (Gaines and Kimbrough, 1970;Davison et al, 1976;Fulfs et al, 1977;Ulland et al, 1977a;Yarbrough et al, 1981), cytopla...…”

“…Adaptive responses of the liver seen after oral exposure of rats, mice, or gerbils to chlordecone include: (1) increases in liver size or weight (Huber, 1965;Chernoff and Rogers, 1976;Fabacher and Hodgson, 1976;Mehendale et al, 1977bMehendale et al, , 1978bCannon and Kimbrough, 1979;Curtis and Mehendale, 1979;Larson et al, 1979b;Mehendale, 1981b;Fujimori et al, 1983;EPA, 1986c;Schutzmann, 1986, 1987;Simmons et al, 1987;Purushotham et al, 1988); (2) increased hepatocellular hypertrophy (Cannon and Kimbrough, 1979); (3) increased smooth endoplasmic reticulum Lockard et al, 1983a,b;Mehendale et al, 1989); (4) increased microsomal protein (Mehendale et al, 1978b;Mehendale, 1982b, 1983b;Chambers and Trevethan, 1983); (5) increased cytochrome P-450 content (Fabacher and Hodgson, 1976;Mehendale et al, 1978b;Mehendale, 1982b, 1983b;Chambers and Trevethan, 1983;Fujimori et al, 1983;Agarwal and Mehendale, 1984a;Britton et al, 1987;Kitchin and Brown, 1989;Cai and Mehendale, 1990;Chaudhury and Mehendale, 1991;Kocarek et al, 1991); (6) increased NADPH2-cytochrome c reductase (Mehendale et al, 1977b(Mehendale et al, , 1978bChambers and Trevethan, 1983;Fujimori et al, 1983); (7) and/or increased microsomal enzyme activity …”