Potentiation by chlordecone of the defect in hepatic microsomal calcium sequestration induced by carbon tetrachloride

Hegarty, Joel M.; Glende, Eric A.; Recknagel, Richard O.

doi:10.1002/jbt.2570010207

Cited by 3 publications

(1 citation statement)

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“…Similarly, a recent study (Cai and Mehendale, 1993) has shown that young rats with greater hepatocellular regenerative activity than adult rats also experience less hepatocellular damage following exposure to both chlordecone and carbon tetrachloride. Cellular changes that may facilitate the chlordecone-induced suppression of regeneration include marked depletion of hepatocellular glycogen (Lockard et al, 1983a,b;Bell and Mehendale, 1987;Faroon et al, 1991), depletion of ATP (Kodavanti et al, 1990a;Faroon et al, 1991), and disruptions in the regulation of intracellular calcium Mehendale, 1984a,c,d, 1986;Hegarty et al, 1986;Kodavanti et al, 1991). It has been demonstrated that suppression of cell division due to glycogen depletion results in decreased ATP availability and, consequently, suppressed cellular regeneration Mehendale, 1993, 1994).…”

Section: Interactions With Other Substancesmentioning

confidence: 99%

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Additional substances will be profiled in a series of manuscripts to follow.

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Section: Interactions With Other Substancesmentioning

confidence: 99%

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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Potentiation of carbon tetrachloride hepatotoxicity by chlordecone: Dose‐response relationships and increased covalent binding in vivo

Britton

Dolak

Glende

et al. 1987

J. Biochem. Toxicol.

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Chlordecone greatly potentiates carbon tetrachloride (CCl4) hepatotoxicity. In order to quantitate the degree of this potentiation, the effects of a range of doses of CCl4 on two microsomal enzymatic functions and liver enzyme release were examined in chlordecone-treated and control rats. Male Sprague-Dawley rats were pretreated with 15 mg chlordecone per kilogram body weight (BW) intragastrically or with vehicle. After 48 hours, 0 to 250 microliters CCl4 per 100 g body weight were given intraperitoneally (IP), and the rats were killed 24 hours later. Chlordecone treatment produced approximately a 17-fold potentiation of the CCl4-dependent loss of cytochrome P-450 and glucose-6-phosphatase activity, so that a dose of 6 microliters CCl4 per 100 g body weight in the chlordecone-treated animals resulted in a similar amount of damage as observed with 100 microliters CCl4 per 100 g body weight in controls. A similar potentiation by chlordecone was seen with CCl4 induced increases in serum glutamic-oxaloacetic transaminase (SGOT) levels. Chlordecone treatment also increased hepatic cytochrome P-450 levels by 67% and resulted in an increase in the covalent binding of [14-C]-CCl4-derived metabolites to microsomal protein and lipid in vivo.

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DDT and Other Chlorinated Insecticides

Smith

2012

Mammalian Toxicology of Insecticides

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The use of organochlorine insecticides such as DDT, lindane and cyclodieneshas declined markedly worldwide over the last decades. Most are now banned or not used. At an acute toxicity level they have been relatively safe in use for humans. However, the greatest concerns are their persistence in people, wildlife and the environment due to their slow metabolism. Although their carcinogenicity for humans has not been supported by strong epidemiological evidence, their potential to be modulators of endocrine and immune function at levels remaining in the environment or associated with residual spraying of DDT continue to be of concern. At present, DDT is still allowed by the United Nations for combating malaria, with continual monitoring and assessment where possible. The toxicological consequences of exposure of animals and people to DDT is discussed as well as some analogues and other insecticides such as lindane, dieldrin and chlordecone that, although little used, continue to persist in surroundings and people. Because of circumstances of world health brought about by climate change or human activities that have yet to develop, there may come a time when the importance of some may re-emerge.

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Potentiation by chlordecone of the defect in hepatic microsomal calcium sequestration induced by carbon tetrachloride

Cited by 3 publications

References 12 publications

Atsdr Evaluation of Health Effects of Chemicals

Atsdr Evaluation of Health Effects of Chemicals

Potentiation of carbon tetrachloride hepatotoxicity by chlordecone: Dose‐response relationships and increased covalent binding in vivo

DDT and Other Chlorinated Insecticides

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