Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

Bjørklund, Geir; Antonyak, Halyna; Polishchuk, A. I.; Semenova, Yuliya; Lesiv, Marta; Lysiuk, Roman; Peana, Massimiliano

doi:10.1007/s00204-022-03366-3

Cited by 13 publications

(6 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Humans typically contact with Hg from three main sources: dental amalgam fillings, some vaccines, and fish caught in rivers and seas contaminated with Hg waste [10,164]. In addition, Hg-containing devices-such as electric lamps, thermometers, barometers, etc.-are potential sources of Hg in the home [165,166].…”

Section: Curcumin On Mercury-induced Toxicitymentioning

confidence: 99%

A Review of the Role of Curcumin in Metal Induced Toxicity

et al. 2023

View full text Add to dashboard Cite

Metal toxicity poses a potential global threat to the environment and living beings. Their numerous agricultural, medical, industrial, domestic, and technological applications result in widespread distribution in the environment which raises concern on the potential effects of metals in terms of health hazards and environmental pollution. Chelation therapy has been the preferred medical treatment for metal poisoning. The chelating agent bounds metal ions to form complex cyclic structures known as ‘chelates’ to intensify their excretion from the body. The main disadvantage of synthetic chelators is that the chelation process removes vital nutrients along with toxic metals. Natural compounds are widely available, economical, and have minimal adverse effects compared to classical chelators. Herbal preparations can bind to the metal, reduce its absorption in the intestines, and facilitate excretion from the body. Curcumin, a bioactive substance in turmeric, is widely used as a dietary supplement. Most studies have shown that curcumin protects against metal-induced lipid peroxidation and mitigates adverse effects on the antioxidant system. This review article provides an analysis to show that curcumin imparts promising metal toxicity-ameliorative effects that are related to its intrinsic antioxidant activity.

show abstract

Section: Curcumin On Mercury-induced Toxicitymentioning

confidence: 99%

A Review of the Role of Curcumin in Metal Induced Toxicity

et al. 2023

View full text Add to dashboard Cite

show abstract

“…According to Rand Lab, URMC (2022, evaluating the potential for MeHg toxicity relies on the accurate prediction of the body burden of Hg that results from eating fish (Figure 3). As already indicated, exposure to MeHg through the consumption of seafood and fish can seriously affect foetal neurobehavioral development (i.e., motor impairment) even when MeHg levels in maternal blood are quite low, say around 5 μg/L, which the mother tolerates well (See: Bjørklund et al, 2022).…”

Section: Mechanism Of Toxicitymentioning

confidence: 99%

“…Rand Lab, URMC data are being used to inform development of a physiologically based pharmacokinetic (PBPK) model in silico capable of predicting MeHg kinetics in humans (Rand Lab, URMC, 2022). Impairment of extra-cerebellar functions can result from the actions of MeHg on thiol groups in the neuronal cytoskeleton as well as on mitochondrial enzymes and induction of disturbances of glutamate signalling (Bjørklund et al, 2022). Antunes dos Santos et al (2018) review the general interactions between MeHg with regulators of the antioxidant response system that are rich in thiol and selenol groups such as glutathione (GSH), and the selenoenzymes thioredoxin reductase (TrxR) and glutathione peroxidase (Gpx).…”

Section: Mechanism Of Toxicitymentioning

confidence: 99%

An updated review of the salient geomedical aspects of mercury for enhancement of data quality in simulation modelling and other prognostic applications: Africa case descriptions

Davies

2023

Front. Anal. Sci.

View full text Add to dashboard Cite

Mercury (Hg) pollution is of global concern. Despite the prolificity of research in the past two decades or so, there are still several uncertainties and variabilities in our knowledge of both the element’s exposure dynamics and its health effects. Understanding the intricacies of the element’s emissions-to-impact path, for instance, is rendered intractable by its varied environmental fate and the overarching influence of environmental, geochemical, biological and socioeconomic drivers. In this paper, an updated synopsis of the relevant and more important geomedical characteristics of Hg is considered to constitute part of the provision of high-quality input data needed in Hg simulation modelling studies, and other applications such as the provision of long-term data necessary for evaluating the effectiveness of regulatory measures at various scales. A critical overview is presented on the importance of data quality in parameterisation, and validation of Hg simulation models and other related applications. In this connection, the dearth of modern measurements of Hg abundance in crustal rocks and other Earth materials which needs to be set prior to simulation as well as in modelling source to sink transfers in the Hg cycle, is highlighted. An improved input data quality would also foster the production of model outcomes that are accurate enough for applications in design of better exposure-limiting strategies; and in providing insights on how the course of diagnosis and treatment currently proffered by physicians for Hg-induced maladies, can be revised or expanded. Model results derived from high-quality input datasets also have a high potential for providing forecasting capabilities to inform policy.

show abstract

“…Mercury poisoning may cause inhibition of glutamate decarboxylase activity and additionally may reduce dopamine and serotonin levels in the brain [ 253 , 254 ]. There is no doubt that too much Hg may cause harm to the brain [ 255 ]. Still, it is a challenging task to assess more quantitatively the consequences of Hg in a health context in comparison with other toxic metals, alcohol, unnatural Ah receptor agonists (including PCBs, PAHs, and various brominated flame retardants) [ 256 ] or mutagenic drugs, such as paracetamol [ 257 ].…”

Section: Multiple Sclerosismentioning

confidence: 99%

The Role of the Thioredoxin System in Brain Diseases

et al. 2022

Self Cite

View full text Add to dashboard Cite

The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis. Aberrations in the Trx system may lead to increased oxidative stress toxicity and neurodegenerative processes. This study reviews the role of the Trx system in the pathophysiology and treatment of Alzheimer’s, Parkinson’s and Huntington’s diseases, brain stroke, and multiple sclerosis. Trx system plays an important role in the pathophysiology of those disorders via multiple interactions through oxidative stress, apoptotic, neuro-immune, and pro-survival pathways. Multiple aberrations in Trx and TrxR systems related to other redox systems and their multiple reciprocal relationships with the neurodegenerative, neuro-inflammatory, and neuro-oxidative pathways are here analyzed. Genetic and environmental factors (nutrition, metals, and toxins) may impact the function of the Trx system, thereby contributing to neuropsychiatric disease. Aberrations in the Trx and TrxR systems could be a promising drug target to prevent and treat neurodegenerative, neuro-inflammatory, neuro-oxidative stress processes, and related brain disorders.

show abstract

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

Cited by 13 publications

References 193 publications

A Review of the Role of Curcumin in Metal Induced Toxicity

A Review of the Role of Curcumin in Metal Induced Toxicity

An updated review of the salient geomedical aspects of mercury for enhancement of data quality in simulation modelling and other prognostic applications: Africa case descriptions

The Role of the Thioredoxin System in Brain Diseases

Contact Info

Product

Resources

About