Background and aim: Plukenetia conophora Mull. Arg. (African walnut) belongs to the Euphorbiaceae family. Thesignificance of wood anatomy in relation to taxonomy is by no means new or recent. Aim: The work evaluates theanatomy of the leaf, stem, root and the nutritional values of the leaves of Plukenetia conophora. Methodology: Leafepidermal strips were made by Impression technique and all sectionings (TS, TLS and RLS) were made with Reichertsliding microtome. Standard stains were used to differentiate the tissues. The proximate and mineral analyses werecarried out using standard methods. Results: Anatomical studies showed hypostomatic leaves with anomocyticstomata and no trichomes. Concentric vascular bundles were observed in the transverse sections of the leaf andpetiole. The various sections of the stem anatomy revealed diffuse-in-aggregate vessels with scanty axial parenchymain the transverse section, both uniseriate and biseriate rays in the transverse longitudinal section, and procumbent raysin the radial longitudinal section. Nutritional analysis showed presence of all the tested proximate and minerals. Theleaves contained proximate: carbohydrates (25.57 ± 0.05), protein (18.02 ± 0.02), ash (29.36 ± 0.33), moisture (18.06± 0.03), crude fibre (9.83 ± 0.17) and fat (7.41 ± 0.11) and minerals: calcium (19.18 ± 0.00), potassium (14.01 ± 0.00)and sodium (7.97 ± 0.03), Zinc (0.70 ± 0.01), magnesium (1.91 ± 0.01), iron (4.93 ± 0.04) and manganese (0.91 ±0.00). Conclusion: The anatomical results are quite useful in the delimitation of this species and nutritional resultssuggest the use of the leaves as a healthy food.