Effect of menopause on lipid profile in relation to body mass index

Bade, Geetanjali; Shah, Swati; Nahar, Pradeep; Vaidya, Sagar A.

doi:10.4103/2229-5186.129331

Cited by 16 publications

(9 citation statements)

References 5 publications

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“…Analogous findings were observed by Bade S and SHAH S [26].They found that, "the levels of TC (246.62 ± 29.19mg %) and TG (131.22±18.99mg %) were significantly higher in post-menopausal women than those of pre-menopausal counterparts (P < 0.05). HDL-C levels were significantly lower (moderate risk category P <0.001) and LDL-C (224.21±30.98mg %) levels were also significantly higher in postmenopausal group.…”

Section: Discussionsupporting

confidence: 78%

Evaluating the Comparative Values of Lipid Profile among Premenopausal and Postmenopausal Women

Alamgir¹,

Ahmed²,

Raza³

et al. 2017

ujcm

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Objectives: The study aims at comparing the changes of serum lipid levels in premenopausal women with that of postmenopausal counterparts. Study Design: An observational comparative and prospective study. Subjects and Method: One hundred healthy subjects (fifty each pre and postmenopausal women) between ages from 25 to 65 years, were selected for the study. They were nonsmoker, non-addict and not user of any hormonal contraceptive. The subjects were arranged in two age ranges of 25-45 years (group A) and 45-65 years of age (group B) .The quantitative data was collected and applied accordingly. The fasting serum lipids samples consisting of total cholesterol (TC), high density lipoproteins (HDL-C), and triglyceride (TG) were estimated calorimetrically using the enzymatic method. NCEP ATPIII criterion was used to determine their values in normal or high risk category. According to their recommendations, in healthy females, total cholesterol should be < 200mg/dl .The quantitative variables were displayed as mean ± standard deviation and percentage. The statistical difference for lipoproteins at 5% significance level was assessed by applying one sample "t" test. Results: In subjects of group A, the mean total cholesterol and HDL-C levels were 158.14±28.77mg/dl and 38.98±8.48 mg/dl respectively. Triglycerides level was 142.24±88.387 mg/dl and within normal range. In females with age group B, the mean concentration of total cholesterol and HDL-C were 210.74±59.156mg/dl, 32.94±7.582.mg/dl respectively. Triglycerides level was 160.68±68.131 mg/dl. So in subjects of group B, all lipid values were in high risk category when compared to cut off values determined by NCEP/AHA. Conclusion: Menopause leads to changes in lipid profile by reducing HDL, and elevating total cholesterol (TC), and triglycerides (TG), thus increasing the risk for cardiovascular events.

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Section: Discussionsupporting

confidence: 78%

Evaluating the Comparative Values of Lipid Profile among Premenopausal and Postmenopausal Women

Alamgir¹,

Ahmed²,

Raza³

et al. 2017

ujcm

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“…31 On the other hand recent studies reported that obesity as a common risk for breast cancer and dyslipidemia. 18,33,34 This could be due to adiposity-related secretion of estrogen, increases in circulating insulin and insulin-like growth factors, local production of adipokines and leptin that could stimulate the breast cell growth. 35 In addition, obesity decreases the production of sex hormone-binding globulin which in turn results foran increased biologically active unbound form of estrone and estradiol which promotes cell growth and metastatic potential in breast tumor.…”

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confidence: 99%

<p>The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia</p>

Kumie¹,

Melak²,

Baynes³

2020

BCTT

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Background Breast cancer is a malignant condition affecting about 2.1 million women worldwide. Cancer cells have increased the level of cholesterol and facilitate lipid biosynthesis and metabolism. Therefore, there is a need for assessment of serum lipid and its association with breast cancer risks. Methods A comparative cross-sectional study was conducted among women with breast cancer (n=23), benign breast lump (n=68) and apparently healthy control (n=91) at Felege Hiwot Comprehensive Specialized Hospital, from January to May, 2020. A convenient sampling technique and an interviewer-administered questionnaires were used to collect data. Five milliliter of fasting blood sample was collected for lipid level analysis using enzymatic colorimetric method. Data entry and analysis were done using Epi Info version 7 and SPSS version 20. One way ANOVA and logistic regression were the tools used for analysis, and a p-value of <0.05 was considered as statistically significant. Results The mean age of healthy control, benign and malignant breast cancer was 32.51±9.44, 33.34±10.664 and 37.65±14.345 years, respectively. The mean serum value of TG among controls, benign and malignant women was 168.67±41.616, 170.1±59.018 and 211.7±82.924 (p<0.001), respectively. The mean serum concentration of HDL-c was significantly different between the three groups (47.61±9.122, 44.69±14.479 and 38.26±7.442: p=0.004) among controls, benign and malignant, respectively. Low serum HDL-c level was significantly associated with age at parity (AOR=3.353; 95% CI=1.33, 8.436), the habit of drinking alcohol (AOR=2.125; 95% CI=1.065, 4.241) and BMI (AOR=3.555; 95% CI=1.13, 11.184). In addition, BMI (AOR: 4.54; 95% CI: 1.45, 14.21) was statistically associated with high LDL-c level. Conclusion The overall prevalence of dyslipidemia was high in breast cancer patients. Age at first parity, alcohol consumption and BMI were significantly associated with low serum HDL-c level.

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“…16 Lipid profile is altered in menopause because of various reasons especially the changes in hormone levels which control most other metabolic activities of the human body like the estrogen. 17 This study at baseline revealed that serum levels of TG, LDL-C and VLDL-C were higher in postmenopausal women when compared to the levels after the intervention with honey. The alteration in lipid profile may be due to impairment in fatty acid metabolism.…”

Section: Discussionmentioning

confidence: 75%

“…16 Lipid profile have been found to be altered in menopause because of various reasons especially the changes in hormone levels which control most other metabolic activities of the human body like the estrogen. 17 The study therefore seeks to elucidate the changes in lipid profile of menopausal women after treatment with honey for four months.…”

Section: Introductionmentioning

confidence: 99%

Changes in lipid profile and some biochemical parameters in postmenopausal women treated with honey

Ugorji

Meludu²,

Ogbu³

et al. 2021

JPMHH

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The study investigated the effect of natural honey on the lipid profile and some biochemical parameters among postmenopausal women, aged 45-65 years old. Sixty healthy postmenopausal women were given 20 g/day of natural honey and followed up for three months. The primary outcome was changes from baseline on the lipid profile and the chosen biochemical parameters (fasting blood sugar, serum calcium) and some anthropometric parameters. Paired t-test was performed to evaluate the difference between the baseline and the 3 month values of the parameters and lipid profiles. Sixty postmenopausal women successfully completed the study. The result showed that there were significant increases in HDL-C, calcium and significant decreases in LDL-C, TG, TC, and FBS concentrations in the blood of the research subjects after three months of treatment with honey compared with the values at baseline (p<0.05). Also there were significant decreases in the blood pressure, weight and waist circumference of the postmenopausal women after treatment when compared with baseline values (p<0.05). Natural honey helps in improving the lipid profile, FBS, Blood pressure, weights and waist circumference of postmenopausal women and can be included as part or alternative remedies in management of postmenopausal conditions.

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Effect of menopause on lipid profile in relation to body mass index

Cited by 16 publications

References 5 publications

Evaluating the Comparative Values of Lipid Profile among Premenopausal and Postmenopausal Women

Evaluating the Comparative Values of Lipid Profile among Premenopausal and Postmenopausal Women

<p>The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia</p>

Changes in lipid profile and some biochemical parameters in postmenopausal women treated with honey

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