<p>The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia</p>

Abstract

Background Breast cancer is a malignant condition affecting about 2.1 million women worldwide. Cancer cells have increased the level of cholesterol and facilitate lipid biosynthesis and metabolism. Therefore, there is a need for assessment of serum lipid and its association with breast cancer risks. Methods A comparative cross-sectional study was conducted among women with breast cancer (n=23), benign breast lump (n=68) and apparently healthy control (n=91) at Felege Hiwot Comprehensive Specialized Hospital, from January to May, 2020. A convenient sampling technique and an interviewer-administered questionnaires were used to collect data. Five milliliter of fasting blood sample was collected for lipid level analysis using enzymatic colorimetric method. Data entry and analysis were done using Epi Info version 7 and SPSS version 20. One way ANOVA and logistic regression were the tools used for analysis, and a p-value of <0.05 was considered as statistically significant. Results The mean age of healthy control, benign and malignant breast cancer was 32.51±9.44, 33.34±10.664 and 37.65±14.345 years, respectively. The mean serum value of TG among controls, benign and malignant women was 168.67±41.616, 170.1±59.018 and 211.7±82.924 (p<0.001), respectively. The mean serum concentration of HDL-c was significantly different between the three groups (47.61±9.122, 44.69±14.479 and 38.26±7.442: p=0.004) among controls, benign and malignant, respectively. Low serum HDL-c level was significantly associated with age at parity (AOR=3.353; 95% CI=1.33, 8.436), the habit of drinking alcohol (AOR=2.125; 95% CI=1.065, 4.241) and BMI (AOR=3.555; 95% CI=1.13, 11.184). In addition, BMI (AOR: 4.54; 95% CI: 1.45, 14.21) was statistically associated with high LDL-c level. Conclusion The overall prevalence of dyslipidemia was high in breast cancer patients. Age at first parity, alcohol consumption and BMI were significantly associated with low serum HDL-c level.

The Effect of Genistein Supplementation on Cholesterol Oxidation Products and Fatty Acid Profiles in Serums of Rats with Breast Cancer

“…In this complex process, cells deregulate cholesterol homeostasis, causing intracellular cholesterol accumulation, which is required to maintain their high growth rate. Cancer cells increase the level of cholesterol, facilitating the biosynthesis and metabolism of lipids, and metabolites derived from cholesterol support the progression of cancer and suppress the immune response [ 23 , 24 ]. In our study, the concentration of cholesterol was the highest in the group of animals fed with nanogenistein ( p = 0.02), which may indicate an intense proliferation of tumor cells in this group of rats.…”

Serum fatty acid transport protein 1 in women with and without breast cancer

“…Abnormal lipid metabolism has been identified as a major metabolic event during cancer development thus leading to alteration in the lipid profile levels (18)(19)(20). Dyslipidemia with low HDL levels and increased TAG, TC, LDL, and VLDL levels raises the risk of developing BC (9,10). Present study evaluated the levels of lipid profile in subjects with and without bc and found a significant rise in TC, LDL, TAG and VLDL, as well as reduced HDL-C levels in the former group, compared to the control group.…”

“…Obesity influences the serum lipid profile and causes dyslipidemia, which can negatively affect the integrity of the cells (9). As a result, elevated levels of serum cholesterol (TC), triglycerides (TAG) and abnormality of LDL-C and HDL-C are reported under BC subjects (10). Fatty acid transport and channeling play a significant role in cancer and lipid metabolism.…”

Hubungan Kadar LDL(Low Density Lipoprotein) Dengan Tumor Payudara Yang Dicurigai Berisiko Maligna

“…Hal ini dipengaruhi oleh usia paritas pertama, konsumsi alkohol dan indeks masa tubuh yang secara signifikan dikaitkan dengan rendahnya kadar serum HDL. 8 Penelitian yang dilakukan oleh Christoph, et al, tahun 2018 juga menunjukkan bahwa peningkatan kadar LDL memiliki risiko yang lebih tinggi pada kanker payudara dan reseptor estrogen yang positif. Pada penelitian ini juga menyebutkan peningkatan kadar HDL secara genetik dikaitkan dengan risiko estrogen positif yang lebih tinggi pada kanker payudara.…”