Evaluating the Comparative Values of Lipid Profile among Premenopausal and Postmenopausal Women

Abstract

Objectives: The study aims at comparing the changes of serum lipid levels in premenopausal women with that of postmenopausal counterparts. Study Design: An observational comparative and prospective study. Subjects and Method: One hundred healthy subjects (fifty each pre and postmenopausal women) between ages from 25 to 65 years, were selected for the study. They were nonsmoker, non-addict and not user of any hormonal contraceptive. The subjects were arranged in two age ranges of 25-45 years (group A) and 45-65 years of age (group B) .The quantitative data was collected and applied accordingly. The fasting serum lipids samples consisting of total cholesterol (TC), high density lipoproteins (HDL-C), and triglyceride (TG) were estimated calorimetrically using the enzymatic method. NCEP ATPIII criterion was used to determine their values in normal or high risk category. According to their recommendations, in healthy females, total cholesterol should be < 200mg/dl .The quantitative variables were displayed as mean ± standard deviation and percentage. The statistical difference for lipoproteins at 5% significance level was assessed by applying one sample "t" test. Results: In subjects of group A, the mean total cholesterol and HDL-C levels were 158.14±28.77mg/dl and 38.98±8.48 mg/dl respectively. Triglycerides level was 142.24±88.387 mg/dl and within normal range. In females with age group B, the mean concentration of total cholesterol and HDL-C were 210.74±59.156mg/dl, 32.94±7.582.mg/dl respectively. Triglycerides level was 160.68±68.131 mg/dl. So in subjects of group B, all lipid values were in high risk category when compared to cut off values determined by NCEP/AHA. Conclusion: Menopause leads to changes in lipid profile by reducing HDL, and elevating total cholesterol (TC), and triglycerides (TG), thus increasing the risk for cardiovascular events.

Pandemic of Cardiovascular Diseases among Post-Menopausal Women; A Brain Storming Update

“…Lipid abnormalities are characteristically unique among post-menopausal women [11]. Although, raised total and LDL cholesterol has been observed with cardiovascular events but some of the studies revealed no association among them.…”