Effect of maternal cottonseed feed on the immune and antioxidant status of Santa Ines lambs

Moretti, Débora Botéquio; Jimenez, Carolina Rodriguez; Trinca, Heloisa M.; Machado‐Neto, Raul; Louvandini, Hélder

doi:10.1016/j.cimid.2018.11.005

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Santa Inês ewes (Ovis aries) from the Center for Nuclear Energy in Agriculture at the University of São Paulo, Brazil, were used in a completely randomized design in order to evaluate the effect of gestational and lactational exposure to cottonseed-derived gossypol on testis development and testis gene expression in lambs. From conception until 60 days postpartum, ewes were individually supplemented with a control diet based on corn and soybean or a gossypol-rich diet based on cottonseed [35]. Ewes had ad libitum access to hay and forage (pastures of Panicum maximum cv.…”

Section: Animals Experimental Design and Maternal Dietsmentioning

confidence: 99%

Gestational and lactational exposure to gossypol alters the testis transcriptome

et al. 2020

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Background: Reproductive capacity can be altered by challenges experienced during critical periods of development, including fetal development and early neonatal life. Gossypol is a polyphenolic compound, commonly found in cotton seeds, that impairs male reproduction. Here, we investigated whether the exposure to gossypol in utero and during lactation alters male reproductive function in sheep. From conception until 60 days postpartum, ewes were randomly assigned to a control diet or a gossypol-rich diet based on cottonseed. Lamb testicles were removed at 60 days of age and subjected to RNA-sequencing. Results: Lambs derived from the maternal cottonseed diet showed significantly lower growth and lower testis weight as a proportion of the total body weight, and reduced testosterone levels. In addition, the testis transcriptome was significantly altered by the maternal cottonseed diet. Most of the altered genes are directly implicated in testis development and sperm biology, cell communication, iron ion metabolism, calcium homeostasis and signaling, among other functions. Interestingly, network analysis revealed that exposure to gossypol significantly disturbed coexpression patterns among spermatogenesis-related genes, suggesting a disruption in coregulation mechanisms. Conclusions: Our findings provide evidence that maternal exposure to gossypol alters male reproductive function in the offspring, with potential lasting or lifelong negative consequences.

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Section: Animals Experimental Design and Maternal Dietsmentioning

confidence: 99%

Gestational and lactational exposure to gossypol alters the testis transcriptome

et al. 2020

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“…Biomarkers of oxidative stress provide data regarding the monitoring of different procedures to reduce the parasite load and GIN in sheep [ 40 , 47 , 48 , 49 ], stress monitoring [ 50 ], and evaluation of diets fed to lambs [ 51 ] as well as the intake of cottonseed [ 52 ] in the oxidative status of sheep.…”

Section: Discussionmentioning

confidence: 99%

Effect of Supplementation of Lambs with Whole Cottonseed: Impact on Serum Biomarkers and Infection by Gastrointestinal Parasites under Field Conditions

et al. 2023

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The purpose of this trial was to evaluate serum levels of oxidative stress biomarkers and biochemical analytes in crossbred lambs during the rearing phase in an integrated crop-livestock system (ICLS) to control gastrointestinal parasites. The experiment used 36 crossbred lambs (cross: Ile de France × White Dorper × Texel) divided into two groups. The WCS group was supplemented with whole cottonseed (WCS), and controls had no supplementation. Body weight, blood collection, and fecal analysis of nematode eggs and Eimeria oocysts counting per gram of feces were performed for each animal within 84 days of experiment. The following serum analytes were determined: total protein, albumin, globulin, cholesterol, haptoglobin, and 10 oxidative stress biomarkers: cupric reducing antioxidant capacity, ferric reducing ability of plasma, trolox equivalent antioxidant capacity, thiol, uric acid, paraoxonase-1, total oxidant status, ferric-xylenol orange, advanced oxidation protein products, and reactive oxygen metabolites derived compounds. The inclusion of WCS suggested the benefit in controlling infection as well as inducing an increase in antioxidants and a decrease in oxidants in lambs naturally infected by gastrointestinal parasites. The combination of WCS and ICLS could be a useful tool in controlling gastrointestinal parasite infection without affecting the production performance.

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“…Chicken meat production with a PCR of 4.7 is superior to that of other animal-based protein sources, such as pigs (5.7), fish (4.6-5.7) and prawns (7.7) (Rathore et al, 2020). Several authors have recently investigated the effect of CSP, CSF, CSC and CSPI on feed diets in aquacultural species (Anderson et al, 2016;Wang et al, 2020;Ye et al, 2020;Yin et al, 2018), pigs , and lambs (Moretti et al, 2019). Delgado et al, (2021) studied the functional properties of the extruded shrimp feed containing CSM with ultra-low gossypol content.…”

Section: Cottonseed/cottonseed Meal (Csm) As An Indirect Source Of Pr...mentioning

confidence: 99%

Cottonseed: A sustainable contributor to global protein requirements

Kumar

Tomar

Punia

et al. 2021

Trends in Food Science & Technology

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Effect of maternal cottonseed feed on the immune and antioxidant status of Santa Ines lambs

Cited by 8 publications

References 25 publications

Gestational and lactational exposure to gossypol alters the testis transcriptome

Gestational and lactational exposure to gossypol alters the testis transcriptome

Effect of Supplementation of Lambs with Whole Cottonseed: Impact on Serum Biomarkers and Infection by Gastrointestinal Parasites under Field Conditions

Cottonseed: A sustainable contributor to global protein requirements

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