Effect of Maternal Alcohol Consumption on Epididymal Growth in Neonatal Mice

Onu, JE; Dn, Ezeasor; Ihemelandu, E.C.

doi:10.4314/nvj.v31i4.68983

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…As a result of maternal exposure to Ac and Al individually during gestation and lactation, these substances were passed onto the offspring, resulting in increased birth anomalies, decreased neural development, decreased organ weight, and resulted in morphological changes. [5][6][7][8][13][14][15][16][17][18][19][20][21][22][33][34][35][44][45][46][47][48] Our findings showed that the offsprings' body weights at birth and PND 21 and gonadosomatic index decreased whose mother was exposed to Ac and Al. The decrease in body weight at birth was more significant in the groups treated with Al during gestation, which suggests that Al is a more effective toxin than Ac.…”

Section: Discussionmentioning

confidence: 92%

Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period

2014

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Acrylamide (Ac) in the foods and alcohol (Al) in the drinks are unavoidable. Several previous studies demonstrated that these substances which are taken into the body via diet may cause adverse effects in the cells. However, there is no study about how Ac and Al may affect the male reproductive system of the offspring when consumed by the mother during pregnancy and lactation. For this purpose, sexual development in male mice was evaluated after intake of 14 mg/kg Ac and 2 g/kg Al from gestation day 6 to postnatal day (PND) 21. The weight of the offspring was reduced at birth and PND 21 for those exposed to Ac and/or Al. The gonadosomatic index of male offsprings was reduced except for the Ac-treated lactation group. Both substances induced multinuclear giant cells, degenerative cells, atrophic tubules, and maturation-arrested tubules, while decreased Leydig, Sertoli, and spermatogenic cell numbers. Lipid peroxidation level and superoxide dismutase enzyme activity increased in both Al-treated and Ac and Al-treated groups. There was only reduction in the catalase activity during the gestation and lactation periods. These findings suggest that consumption of Ac together with Al may induce impairments on testicular spermatogenesis in male offsprings.

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Section: Discussionmentioning

confidence: 92%

Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period

2014

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“…It has been observed that alcohol during pregnancy adversely affects the regulation mechanism of growth of offsprings and the effect persisted after birth {(Lolyed-Still, 1976), (Leichterand Lee, 1999) and (Taylor, 1984)} observed that alcohol impaired the fetal hormonal system. The retardation of growth of testes and accessory sex organs could be as a result of impairment of fetal hormonal system as a result of disruption of hypothalamic pituitary gonadal axis (Onu et al, 2010). In conclusion this study demonstrates that maternal alcohol consumption during pregnancy and lactation periods would result in some deleterious effects in the reproductive organs of their pups.…”

Section: E E Discussionmentioning

confidence: 66%

Histopathological Effects of Maternal Alcohol Consumption in the Pups of Albino Rats

Ebugosi

Okaka

Onochie

et al. 2017

ESJ

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Alcohol consumption during pregnancy and lactation periods may result to some physical and histopathological changes in offsprings. This study was undertaken to investigate the possible effects of maternal alcohol intake on the testes and accessory sex organs of male pups of albino rats. Three groups of female albino rats; A, B and C were used for this study. Group A was the control group while groups B & C served as test groups. Eight male pups were randomly selected weekly (for five weeks) from each group and were sacrificed. The individual weights of the testes and accessory sex organs were determined and thereafter fixed in formol saline. Histopathological investigation was done and photomicrographs were taken. There was a significant reduction (P<0.05) in the mean weights of the testes in the test groups compared with control in all weeks under study. In contrast a significant reduction (P<0.05) in the mean values of the weights of ventral lobes of prostate and epididymis were only noticed in weeks 5 and 6 while the mean value of weights of the vas deferens showed significant reduction (P<0.05) in week 5 of the test groups compared with control group. The histopathological results revealed that exposure to alcohol caused focal coagulative necrosis of testicular seminiferous tubules in pre-natal alcohol exposed group B and a more diffuse coagulative necrosis of testicular seminiferous tubules in pre-and post- natal alcohol exposed group C. Therefore, there is the need for controlled alcohol consumption during pregnancy and lactation periods.

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“…Since the recognition of FAS, numerous animal studies over the years have demonstrated the deleterious effects of alcohol administration during pregnancy and lactation on the offspring (Onu et al, 2010, Onu et al, 2011, with little attention paid to the dams whose anatomy and physiology can be affected by alcohol. There is paucity of data in the literature on the effects of alcohol on the morphometry of thyroid gland in dams exposed to alcohol during pregnancy and/or lactation.…”

Section: Introductionmentioning

confidence: 99%

Morphometric studies of thyroid gland of Wistar rats exposed to alcohol during pregnancy and/or lactation

Onu¹,

Oke²,

Ozegbe³

et al. 2013

Int. J. Bio. Chem. Sci

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Maternal alcohol consumption during pregnancy and lactation results to some developmental defects such as microcephaly, impairment of central nervous system and mental retardation in the offspring. However, information is limited on the effects of alcohol on the organs of dams being exposed during pregnancy and/or lactation including the thyroid gland. Rat model was employed to investigate the morphometric effects of alcohol on the thyroid gland in dams. 75 female Wistar rats assigned to 3 groups of 25 each were used. Group 1 served as control (C), group 2 and 3 were exposed to alcohol during pregnancy and lactation (APL) and during lactation only (AL) respectively. At Day (D)7, D14, D21, D35 and D49 postpartum, 5 lactating rats were randomly selected from the three groups and sacrificed. After the sacrifice, the thyroids were dissected out and their weights determined. Thereafter, thyroid tissues were fixed in Bouin's fluid and prepared for routine histological examination. The results of the investigation showed significant reduction (p<0.05) in the weights of the thyroid glands. Histological evaluation showed reduced diameter of thyroid follicles, disorganization of follicular cells and desquamation of follicular cells of thyroid glands in alcohol-exposed rats. Our findings suggest that alcohol intake during pregnancy and/or lactation could be injurious to the thyroid glands.

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Effect of Maternal Alcohol Consumption on Epididymal Growth in Neonatal Mice

Cited by 3 publications

References 10 publications

Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period

Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period

Histopathological Effects of Maternal Alcohol Consumption in the Pups of Albino Rats

Morphometric studies of thyroid gland of Wistar rats exposed to alcohol during pregnancy and/or lactation

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