Summary: Malaria in pregnancy is a major contributor to adverse maternal and perinatal outcome. In hyper endemic areas like ours, it is a common cause of anaemia in pregnancy in both immune and non-immune individuals and is aggravated by poor socioeconomic circumstances. The aim of this study is to assess the prevalence of asymptomatic malaria parasitaemia among pregnant women in a rural setting. 272 pregnant women, aged between 18 and 40 years in some remote rural areas of Ebonyi State, Nigeria were recruited between January 2007 and March 2008.Their blood samples were collected and examined for malaria parasite, haemoglobin and packed cell volume using standard methods. Our results showed 59.9% prevalence of parasitaemia with the highest prevalence occurring in the first trimester (84.1%).Among the positive cases, mild parasitaemia was recorded in 47.2% moderate parasitaemia in 37.4% while severe parasitaemia was recorded in 15.3% of cases. These differences were statistically significant (P<0.016). Furthermore the distribution of malaria densities in different gravidity groups showed an inverse relationship, 45.4% in primigravidae, (31.9%) in secundigravidae and (10.4%) among people with more than five pregnancies. These findings were statistically significant (P< 0.0001). The prevalence of anaemia in pregnancy in this study was 62.4%. Apart from the use of nets, drugs and vector control, the prevention of malaria in pregnancy in very poor socioeconomic settings should make provision for nutritional support.

Background:In developing countries, under nutrition is common, and this plays a crucial role in the pathogenesis of malaria and anemia. Indeed it has been associated with adverse pregnancy outcomes. Unfortunately, published evidence concerning the situation is lacking.Objectives:To evaluate some nutritional function indices of pregnant women in a rural Nigerian community.Subjects and Methods:This is a cross sectional study involving of 171 pregnant women from a rural area in South-eastern Nigeria. They included 72 and 99 women in their second and third trimesters respectively. The control group was of 60 women, matched in age, parity and socioeconomic conditions, non-pregnant, non-menstruating and non lactating apparently healthy women. The parameters measured by standard methods included serum iron, total proteins, albumin, globulin, packed cell volume and hemoglobin.Results:The results obtained from control group, second and third trimesters, recorded as Mean (SEM) were 134.60(3.12) μg/L, 101.20(4.48) μg/L and 91.87(3.42) μg/L respectively for iron; 69.12(0.80) g/L, 63.60(0.71) g/L and 57.74(0.75) g/L for total proteins; 42.95(0.92) g/L, 35.74(1.00) g/L and 35.26(0.64) g/L for albumin; 26.77(1.00) g/L, 27.78(1.07) g/L and 22.93(0.88) g/L for globulin; 32.80(0.36%), 27.92(0.37%) and 27.73(0.34%) for packed cell volume, and 11.25(0.11) g/L, 9.59(0.13) g/L and 9.57(0.14) g/L for hemoglobin respectively. These results showed that all the parameters decreased significantly in pregnancy (P<0.001) except globulin that did not show immediate, significant decrease.Conclusion:There is a general decrease in the nutrition parameters studied among the pregnant women from our study area, indicating under-nutrition. Urgent measures should be taken to improve the nutritional status of rural dwellers especially the antioxidant micronutrients.

Sarcocephalus latifolius (Synonym, Nauclea latifolia) is a shrub commonly seen in the South East of Nigeria. It is widely applied as herbal remedy in the treatment of various illnesses. The effect of ethanol extract of the root of the plant on some serum electrolytes was studied. A total of thirty Wistar albino rats were used to determine serum concentrations of K+, Ca2+, Cl- and HCO3-. The animals were divided into six groups of five rats each. Five groups labeled A, B, C, D and E, were administered orally with graded doses of root extract of Sarcocephalus latifolius at concentration of 300, 350, 400, 450 and 500 mg kg(-1) body weight, respectively. The sixth group (Group F) was used as the control and its animals were simply sustained on normal diet and water. Administration of the extract lasted for twenty-one days after which the animals were sacrificed by cardiac puncture. K+, Ca2+, Cl- and HCO3- were determined from each sample and the mean concentration was calculated for each dose and the control. Potassium, calcium and chloride determination were done by colorimetric methods while determination of bicarbonate concentration was done by simple titration. Na+ was separately assayed, by flame photometer, from a set of 18 rats of six animals in each of three groups. For K+, non dose dependent increases were observed which was non-significant (p > 0.05), for A, D and E but significant (p < 0.05) for B and C. Ca2+ showed a dose dependent and significant (p < 0.05) decreases, except for A (p > 0.05). Decreases (p < 0.05) for C, D, E and (p > 0.05) for A and B were observed for Cl-. Serum bicarbonate appeared almost completely unaffected by the extract, showing no significant changes. Na+ levels were depressed for the two test groups, A and B compared with the control (group C), with test group B showing a significant decrease (p < 0.05). From the analysis, it could be concluded that Sarcocephalus latifolius has the capacity to influence various electrolytes to physiologically important degrees. Significant reductions in sodium and calcium levels indicate the usefulness of the plant in treatment of hypertension and pain/fever, respectively. However, significant reductions in chloride may negatively affect the normal balance of fluid in the body. Therefore, more scientific research is needed to establish the best approach to optimizing the numerous medicinal potentials of the plant.

Alcohol consumption during pregnancy and lactation periods may result to some physical and histopathological changes in offsprings. This study was undertaken to investigate the possible effects of maternal alcohol intake on the testes and accessory sex organs of male pups of albino rats. Three groups of female albino rats; A, B and C were used for this study. Group A was the control group while groups B & C served as test groups. Eight male pups were randomly selected weekly (for five weeks) from each group and were sacrificed. The individual weights of the testes and accessory sex organs were determined and thereafter fixed in formol saline. Histopathological investigation was done and photomicrographs were taken. There was a significant reduction (P<0.05) in the mean weights of the testes in the test groups compared with control in all weeks under study. In contrast a significant reduction (P<0.05) in the mean values of the weights of ventral lobes of prostate and epididymis were only noticed in weeks 5 and 6 while the mean value of weights of the vas deferens showed significant reduction (P<0.05) in week 5 of the test groups compared with control group. The histopathological results revealed that exposure to alcohol caused focal coagulative necrosis of testicular seminiferous tubules in pre-natal alcohol exposed group B and a more diffuse coagulative necrosis of testicular seminiferous tubules in pre-and post- natal alcohol exposed group C. Therefore, there is the need for controlled alcohol consumption during pregnancy and lactation periods.

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