Effect of mate tea (Ilex paraguariensis) on the expression of the leukocyte NADPH oxidase subunit p47^phox and on circulating inflammatory cytokines in healthy men: a pilot study

Abstract

Increased superoxide production by phagocytic NADPH oxidase has been associated with inflammatory conditions. Growing evidences suggest that dietary polyphenols may modulate the expression of NADPH oxidase subunits. Herein, we examined whether soluble mate tea (SMT) consumption - a polyphenol-rich beverage - affects the expression of the leukocyte NADPH oxidase protein p47 and/or circulating biomarkers of inflammation and antioxidant biomarkers in humans. In a two-phase study, nine men were requested to drink water (control) for 8 d and then follow a second 8-d period drinking SMT. Blood samples were analysed for p47 protein in CD16/CD14 cells, interleukin (IL)-1β (IL-1β), tumour necrosis factor-alpha (TNF-α), IL-6, total phenols, and reduced and oxidised glutathione (GSH and GSSG, respectively) after each study phase. After SMT intake, CD16/CD14 cells' p47 protein and serum TNF-α and IL-6 levels were significantly attenuated (P < .05) while plasma phenolic compounds and blood GSH:GSSG ratio were significantly enhanced (P < .05). Consumption of SMT favourably affected leukocytes' p47 expression and inflammatory cytokine and antioxidants levels in peripheral blood, which may help decrease oxidative stress and low-grade inflammation.

Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

“…The importance of medicinal plants as a complementary and alternative medicine have been increasing worldwide, all over the years and secondary metabolites of yerba mate and curcumin have become an important strategy against ROS and reducing inflammatory disorders (Alizadeh et al, 2018; Panza, Brunetta, de Oliveira, Nunes, & da Silva, 2019). Moreover, several studies have demonstrated the efficacy of antioxidant supplementation in people with disabilities (Navarrete‐Opazo, Cuitiño, & Salas, 2017; Parisotto et al, 2014).…”

Potential plants for inflammatory dysfunction in the SARS-CoV-2 infection

“…Blood glutathione (GSH) was 16.5% higher in SMT than in the control treatment. SMT ingestion favorably affected inflammatory cytokine and antioxidants levels in peripheral blood, which may help decrease oxidative stress and low-grade inflammation Controlled Clinical Trial (Panza et al 2019 ) I. paraguariensis 3 g of a preparation containing soluble yerba mate plus maltodextrin and artificial peach flavor, corresponding to 107 mg/g total phenols, or mate-placebo for 15 days each, alternating by a washout period of 15 days In 92 individuals on antiretroviral therapy for at least six months and at viral suppression, mean values of HDL-c (mg/dL) at baseline and after receiving yerba mate and placebo mate were 50.6 ± 15, 50.3 ± 14.6, respectively. Fibrinogen levels were within the normal range in 71.7% of the subjects.…”

Yerba mate: cultivation systems, processing and chemical composition. A review

“…In vivo studies show that infusion could inhibit oxidation of LDL (low density lipoprotein), also contributing to treatments of obesity, diabetes, and arteriosclerosis (Godoy et al, 2013;Habtemariam, 2019;Luís et al, 2019). Recent research has shown numerous therapeutic qualities of yerba mate, including hepatoprotective, neuroprotective, resistance against oxidative stress, antiobesity, cardioprotection, and antioxidant effects ( Figure 5) (Baeza et al, 2017;Cahuê et al, 2019;Cittadini et al, 2019b;Panza et al, 2018;Valenca et al, 2019).…”