Effect of manual acupuncture on bowel motility in normal kunming mouse

Zhao, Yong; Changxiang, Cui; Qin, Qing-Guang; Ben, Hui; Gao, Junhong; Yu, Xiao-Chun; Zhu, Bing

doi:10.1016/s0254-6272(15)30033-9

Cited by 11 publications

(3 citation statements)

References 28 publications

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“…Zhu et al also observed the similar acupuncture effect [11, 27]; moreover, they proposed the existence of “homotopic and heterotopic acupoints” to explain the effects and mechanism of action [28]. Homotopic acupoint is in the same spinal cord segment and that of a heterotopic acupoint in a different spinal cord segment, from which the efferent innervates visceral organs; acupuncture at this point could therefore inhibit or facilitate gastrointestinal motility via the sympathetic or parasympathetic pathways [15, 16].…”

Section: Discussionmentioning

confidence: 76%

Electroacupuncture at ST37 Enhances Jejunal Motility via Excitation of the Parasympathetic System in Rats and Mice

Yuan

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Background. The roles of the sympathetic and parasympathetic systems in mediating the effect of electroacupuncture (EA) at ST37 on jejunal motility have yet to be demonstrated. Aim. We used rats and mice to investigate the effect and mechanism of action of EA at ST37 on jejunal motility. Methods. Jejunal motility was recorded by a balloon placed in the jejunum and connected to a biological signal collection system through a transducer. The effects of EA (3 mA) at ST37 were evaluated in Sprague-Dawley rats without drugs and with the administration of clenbuterol, propranolol, acetylcholine, and atropine. Further, the efficacy of EA at different intensities (1/2/4/6/8 mA) was measured in wild-type mice and β 1 β 2 −/− mice and M2M3 −/− mice. Results. In Sprague-Dawley rats, the excitatory effect of EA at ST37 on jejunal motility disappeared in the presence of the muscarinic receptor antagonist atropine. EA at ST37 was less effective in M2M3 −/− mice than in wild-type mice. Furthermore, to a certain extent, there existed “intensity-response” relationship between jejunal motility and EA. Conclusions. EA at ST37 can enhance jejunal motility in rats and mice mainly via excitation of the parasympathetic pathway. There is an “intensity-response” relationship between EA and effect on jejunal motility.

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Section: Discussionmentioning

confidence: 76%

Electroacupuncture at ST37 Enhances Jejunal Motility via Excitation of the Parasympathetic System in Rats and Mice

Yuan

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Previous experimental research has shown the regulatory effect of acupuncture on GI motility. Our previous studies in normal rodents demonstrate that acupuncture at ST36 augments gastric transit,22 jejunal motility, and colonic movement via a somato-parasympathetic pathway 23. In contrast, the effect of acupuncture on colonic motility appears to be quite different under stress conditions.…”

Section: Discussionmentioning

confidence: 93%

Electroacupuncture Ameliorates Abnormal Defaecation and Regulates Corticotrophin-Releasing Factor in a Rat Model of Stress

Zhao

Changxiang

et al. 2017

Acupunct Med

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ObjectiveTo examine the effect of electroacupuncture (EA) treatment on abnormal defaecation in a rat model of chronic heterotypic stress (CHS) and investigate the underlying mechanisms.Methods20 male Sprague-Dawley rats were randomly divided into three groups: normal (n=6), CHS (n=7), and CHS+EA (n=7). Rats in the CHS group and CHS+EA groups received four different types of stressors for 7 days. For rats in the CHS+EA group, EA was applied at ST36 in the bilateral hind legs for 30 min before each stress-loading session. Rats in the normal group did not receive stressors or EA treatment. The faecal pellets of each rat were collected and weighed at a fixed time every day. Protein expression of corticotrophin-releasing factor (CRF) in the hypothalamus and colorectal tissues was measured by Western blotting at the end of the experiment on the 7th day.ResultsAfter 7 consecutive days of CHS, the number of faecal pellets, faecal wet weight, and faecal water content were significantly increased in the CHS group compared with the normal group (p=0.035, p=0.008 and p=0.008, respectively). All three parameters were significantly decreased in CHS+EA versus CHS groups (p=0.030, p=0.011 and p=0.006, respectively). Stress significantly increased CRF expression in both the hypothalamus and colorectal tissues. The excessive CRF responses seen following CHS were significantly suppressed by EA treatment.ConclusionsEA treatment can ameliorate stress loading induced abnormal defaecation in rats and decrease protein expression of CRF centrally (hypothalamus) and peripherally (colorectal tissues), suggesting a potentially therapeutic role for EA in stress-related responses.

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“…O que se conhece é sobre o uso de benzodiazepínicos e uretano em tratamentos de acupuntura do trato gastrintestinal, os quais não interferiram na carga parasitária de Leishmania major (SHAKIBAPOUR et al, 2015) e não alterou os resultados obtidos pela acupuntura (SU et al, 2014;WANG et al, 2012;YUXUE et al, 2015), respectivamente. Não obstante, o uso de barbitúricos em tratamentos de acupuntura provoca aumento de contratilidade gástrica (QIAN et al, 1999;JOAQUIM, 2003 SEQUEIRA, 2002).…”

Section: Discussionunclassified

Estudo Descritivo Sobre O Uso De Folhas Da Batata-Doce E Potencial Para Redução De Efeitos Oxidativos

Salasar¹,

Horn²,

Salazar³

et al. 2019

Análise Crítica Das Ciências Biológicas E Da Natureza 2

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Effect of manual acupuncture on bowel motility in normal kunming mouse

Cited by 11 publications

References 28 publications

Electroacupuncture at ST37 Enhances Jejunal Motility via Excitation of the Parasympathetic System in Rats and Mice

Electroacupuncture at ST37 Enhances Jejunal Motility via Excitation of the Parasympathetic System in Rats and Mice

Electroacupuncture Ameliorates Abnormal Defaecation and Regulates Corticotrophin-Releasing Factor in a Rat Model of Stress

Estudo Descritivo Sobre O Uso De Folhas Da Batata-Doce E Potencial Para Redução De Efeitos Oxidativos

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