Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug

Sahmani, S.; Khandan, Amirsalar; Saber‐Samandari, Saeed; Aghdam, M.M.

doi:10.1016/j.msec.2020.110835

Cited by 62 publications

(20 citation statements)

References 57 publications

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“…In this study, the author loaded collagen microsphere containing BG nanopowder with different content of doped Ce into PCL fibrous scaffolds and their bioactivity and biocompatibility were evaluated in detail. The results confirmed the positive effect of the combination of Ce doped BG nanoparticles encapsulated collagen microspheres on the bioactivity and cell performance of PCL fibers for bone tissue engineering applications 41–62 …”

Section: Resultssupporting

confidence: 61%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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Novel nanosized designed ceramic powders, cerium (Ce) doped bioglass (BG) with various doped Ce content, were synthesized by sol-gel method in order to be employed in the development of PCL fibrous scaffold for bone tissue engineering applications. Characterization techniques such as X-ray diffraction analysis, transmission electron microscopy, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy were employed to evaluate the developed Ce doped BG powders. The results confirmed successful doping of Ce inside BG structure. 0, 1, 3, and 10 wt% Ce doped 58S BG were successfully encapsulated in the collagen microspheres by water-in-oil emulsion method and the average particle size and hydrodynamic diameter of microspheres were determined using scanning electron microscopy and dynamic light scattering analysis, respectively. Next, 0, 1, 3, and 10 wt% Ce doped 58S BG encapsulated collagen microspheres were loaded inside the Poly(ϵ-caprolactone) fibrous scaf-

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Section: Resultssupporting

confidence: 61%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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“…Estas propriedades superparamagnéticas, são importantes em aplicações biológicas, especialmente quando é necessário para se evitar possíveis embolizações dos vasos capilares. Porém, para as NPM's que apresentarem superparamagnetismo, a aglomeração entre elas deve ser mínima, o que é extremamente difícil, pelo fato de as partículas possuírem tamanho manométrico, estas apresentam alta energia de superfície, o que causa uma forte atração entre as partículas coloidais, devido às forças de Van der Waals (Sahmani et al, 2020;Perecin, 2021;Sorescu et al, 2021).…”

Section: Nanopartículas Magnéticasunclassified

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

2022

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

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“…In a study by Russo et al, implantation of a porous HA/magnetite scaffold in a rabbit model of a critical femoral defect was shown to induce and support bone tissue formation with no short-term adverse effects on biocompatibility and bone formation ability compared to IONP-free HA, the current gold standard in the treatment of critical bone defects [ 327 ]. Sahmani et al produced bio mimicking scaffolds with drug delivery capability [ 328 ]. The porous scaffolds, which can potentially be used for biological as well as hyperthermal applications, were prepared from HA and IONPs and loaded with gelatin into which ibuprofen, a non-steroidal and non-inflammatory substance, was incorporated.…”

Section: Hard and Connective Tissue Regeneration And Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug

Cited by 62 publications

References 57 publications

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

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