Effect of Lycopene Application in Rats with Experimental Diabetes Using Lipoprotein, Paraoxonase and Cytokines

Yegin, Sevim Çiftçi; Yur, Fatmagül; Ceylan, Erkan

doi:10.1007/s00232-013-9575-2

Cited by 21 publications

(17 citation statements)

References 25 publications

(28 reference statements)

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“…In a study on diabetic rats with similar timing to ours, 4 weeks of supplementation with lycopene was not able to reduce the levels of TNF-α. 33 Moreover, the literature reports that diets rich in carotenoids result in a rapid increase of these components in plasma, but their effect on inflammation is slower, suggesting slow intracellular accumulation of carotenoids. 34 Other researchers also found no decrease in plasma levels of TNF-α with administration of lycopene in obese individuals.…”

Section: Discussionmentioning

confidence: 99%

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats

et al. 2014

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Background:The kidney is a target organ for injuries caused by advanced glycation end products (AGEs) in obesity. The receptor of AGEs (RAGE) is proinflammatory and appears to have a role in the pathogenesis of renal disease due to obesity.Objective:The aim was to verify the effect of obesity on renal damage and the effect of lycopene on these complicationsDesign and Methods:Male Wistar rats were randomly assigned to receive a control diet (C, n=7) or a high-fat diet plus sucrose (HD+S, n=14) for 6 weeks. After this period, the HD+S animals were randomized into two groups: HD+S (n=7) and HD+S supplemented with lycopene (HD+S+L, n=7). The animals received maize oil (C and HD+S) or lycopene (HD+S+L) for a 6-week period.Results:The HD+S and HD+S+L animals demonstrated insulin resistance (OGTT glucose after 150 min; C: 117.6±3.9

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Section: Discussionmentioning

confidence: 99%

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats

et al. 2014

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“…Lycopene is also found in watermelon, papaya, pink grapefruit and pink guava (Tadmor et al, 2005). Its high antioxidant capacity has been attributed to the open β-cycle in its structure (Yegin et al, 2013). Lycopene is the most predominant carotenoid in tomatoes and has the highest antioxidant property among all dietary carotenoids (Rao and Agrawal, 1999).…”

Section: Introductionmentioning

confidence: 99%

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Eze¹,

Afodun²,

Sulaiman³

et al. 2018

J. Diabetes Endocrinol.

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The purpose of this study is to evaluate the capacity of lycopene against diabetes-induced oxidative damage in Wistar rats. Thirty Wistar rats of both sexes, twenty-five of which were diabetic, were used. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight and it was confirmed by the elevated blood glucose ≥200 mg/dl after three days. The rats were divided randomly into groups 1 to 6, each containing 5 rats. Group 1 (Normal control) and Group 2 (Diabetic control) rats were administered 0.5 ml of olive oil; Groups 3, 4, and 5 rats were respectively administered 10, 20 and 40 mg/kg body weight of lycopene, while Group 6 rats were administered 2 mg/kg body weight of Glibenclamide. All administrations were done orally and once daily for twentyeight days. At the end of the treatment, serum levels of antioxidant enzymes, cortisol and malondialdehyde (MDA) were determined. Administration of graded doses of lycopene to diabetic animals significantly (P<0.05) decreased the blood glucose concentration after four weeks of treatment when compared to diabetic untreated animals. Serum levels of cortisol and MDA (index of oxidative stress) were reduced while there were up-regulated activities of serum endogenous enzymes (superoxide dismutase, catalase and glutathione peroxidase) in diabetic animals treated with all doses of lycopene when compared with diabetic untreated animals. Overall, lycopene attenuated the biomedical alterations in STZ-induced diabetic Wistar rats. Lycopene therefore possesses antioxidant activity at the doses tested in this study.

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“…In a related study, lycopene was found to act as an anti‐diabetic agent by reducing free radical formation. In the studies in which lycopene was given to rats with experimental diabetes induced for four weeks, paraoxonase enzyme levels, which decreased in the diabetes group, increased in the D + L group (Yegin et al, ); HbA1c and glucose levels also decreased (Yuztas et al, ). As shown in this literature review, no study has been conducted on the effects of lycopene on ER α‐positive cells, proliferating cells, apoptotic cells or MDA expression in animals with experimentally induced diabetes.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor α Positive Cells

Sandıkçı

Karagenc

Yıldız

2017

The Anatomical Record

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This study aimed to investigate the changes occurring in estrogen receptor (ER) α-positive cells, proliferating cells, apoptotic cells and malondialdehyde (MDA) expression in the pancreas of experimentally induced adult diabetic rats and to determine the effect of orally administered lycopene on these changes. Experimental diabetes was induced using a single dose of 50 mg/kg streptozotocin (STZ). Following the administration of STZ, four groups of animals were established: Control + corn oil, control + lycopene, diabetic + corn oil and diabetic + lycopene. The expressions of ER α, Ki-67, and MDA were determined through immunohistochemistry in sections taken from pancreas tissue samples at the end of the experiment. Apoptotic cells were determined through the TUNEL method. In the diabetic groups, the densities of ER α expression in islets and ER α-positive cells in exocrine parts increased. Whereas the number of proliferating Ki-67 positive cells was higher in the diabetic groups, no significant difference was observed in terms of apoptotic cell number between the control and diabetic groups. Lycopene in general did not have any effect on any of the parameters analyzed in the study. The presence of ER α-positive cells around the islets was demonstrated for the first time in diabetic groups. Based on these observations, demonstrating the antioxidant effects of lycopene in the pancreas of diabetic rats may be possible by increasing the dose and/or the duration of lycopene. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:2000-2007, 2017. © 2017 Wiley Periodicals, Inc.

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Effect of Lycopene Application in Rats with Experimental Diabetes Using Lipoprotein, Paraoxonase and Cytokines

Cited by 21 publications

References 25 publications

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor α Positive Cells

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