Effect of low modulus titanium plate fixation on rabbit femur bone healing

Abdullah, Norain Binti; MIYAZAKI, Daisuke; Yamamoto, Ei; Ueki, Kosuke; Nakai, Masaaki

doi:10.1557/s43578-022-00616-z

Cited by 3 publications

(15 citation statements)

References 37 publications

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“…The implant plates were cleaned with acetone and ethanol and placed in an ultrasonic cleaning machine for 10 min. These materials were similar to the materials that were used in the previous study, but with different thickness (previous study thickness: 1.5 mm, present study thickness: 0.5 mm) (Abdullah et al, 2022). Owing to thinner size of implant plate, the stiffness of both the implant plates is expected to be lower in the present study, stated in Table 2.…”

Section: Experimental Procedures 21 Implant Plate Materialsmentioning

confidence: 61%

“…The chemical compositions of the materials used in the previous study (Abdullah et al, 2022) are listed in Table 1. The implant plates were made from these two materials.…”

Section: Experimental Procedures 21 Implant Plate Materialsmentioning

confidence: 99%

“…The Ti-64 and TNTZ implant plates were fixed on the defect with two stainless-steel screws (M1 diameters) at both the ends of the implant plate. The fixation state was described in our previous study (Abdullah et al, 2022). On the other hand, sham surgery is fixed as control.…”

Section: Animal Surgerymentioning

confidence: 99%

“…In our previous study, the Ti-64 and TNTZ alloys were used to discuss the effect of stiffness of the implant plates on the new bone formation (Abdullah et al, 2022). The TNTZ alloy exhibited more progressive healing with a better new bone formation ability and achieved superior bone properties, such as a high value of hardness, due to a more mature bone structure in the defect region.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we aim to discuss the effects of the implant plate stiffness on the mechanical stability of the fixation system at the fracture site and new bone formation in rabbit femurs. As an extension of our previous study, this study intentionally used the same types of the implant plates: TNTZ and Ti-64, but with different thickness (Abdullah et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Effect of titanium plate stiffness on bone healing in rabbit femur

Abdullah

MIYAZAKI

Yamamoto

et al. 2022

Mechanical Engineering Journal

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Titanium and its alloys are widely used as orthopedic devices for fixation of bone fractures. A combination of low elastic modulus and suitable implant plate thickness, to adjust the stiffness of the implant plate, can improve the healing process. The present study investigates the effect of titanium plate stiffness on the bone formation during the early stage of healing in rabbit femurs. Materials with different elastic moduli, Ti-29Nb-13Ta-4.6Zr (TNTZ) and Ti-6Al-4V ELI (Ti-64), were used as implant plates, and the effect of plate thickness on the bone healing ability was explored. Two types of titanium implant plates of thickness 0.5 mm were used, and after three weeks, the femurs were harvested. Bone cross-sections of the femur were analyzed using scanning electron microscopy, hematoxylin & eosin staining, and Vickers hardness test. Fixations using both the implant plates showed almost similar bone structures but different average total callus areas. Fixation using the TNTZ implant plate resulted in a larger area of callus formation than that using the Ti-64 implant plate of same thickness, but the callus hardness was almost similar. Therefore, we conclude that an overly flexible fixation system results in an excessive callus formation and delayed union. Suitable implant characteristics can result in enhanced bone healing, superior bone properties, such as improved hardness.

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Section: Experimental Procedures 21 Implant Plate Materialsmentioning

confidence: 61%

“…The chemical compositions of the materials used in the previous study (Abdullah et al, 2022) are listed in Table 1. The implant plates were made from these two materials.…”

Section: Experimental Procedures 21 Implant Plate Materialsmentioning

confidence: 99%

Section: Animal Surgerymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of titanium plate stiffness on bone healing in rabbit femur

Abdullah

MIYAZAKI

Yamamoto

et al. 2022

Mechanical Engineering Journal

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Osseointegration and Histopathological Evaluation of Titanium–Titanium Diboride Composite Compared to Pure Titanium Implant Materials Prepared by Powder Metallurgy (In Vivo Study)

Aljafery,

Fatalla,

Haider

2024

J Biomed Mater Res

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The efficacy and osseointegration rate of an implant depend on its biocompatibility. Modern implantology seeks fast and reliable osseointegration, which is essential for clinical success. The objective of this research was to assess the osseointegration and biocompatibility of a titanium–titanium diboride composite (Ti‐TiB2) in rabbits in contrast to those of pure titanium (Ti). A total of 64 cylindrical implant specimens were fabricated, consisting of two sets: pure Ti (32 implants) and Ti‐TiB2 composite (32 implants). In this study, two implants were implanted per tibia (left and right tibias) in 16 white male New Zealand rabbits, for a total of four implants per rabbit (4 × 16 = 64 implants). A pushout test was used to assess implant specimen‐bone bonding after 2 and 6 weeks of healing. The experiment utilized five rabbits per healing phase, which means that 20 implants per time point were used for the pushout tests. (10 for pure Ti and 10 for the composite). Histology was used to examine the tissue response to biocompatibility, and histomorphometry was used to measure new bone growth at the two time points. With three rabbits per time point, 12 implants were employed for the histological analyses. After implantation, the pushout shear strength results revealed that the mean shear strength of the Ti‐TiB2 implant specimens (5.4 ± 0.029 MPa for 2 weeks, 7.9 ± 0.029 MPa for 6 weeks) was statistically greater (p < 0.0001) than that of the pure Ti implant specimens (5.1 ± 0.015 MPa for 2 weeks, 6.6 ± 0.047 MPa for 6 weeks). After 2 weeks, woven bone tissues were observed around the pure titanium implants, and active osteoid tissue around the composite implants exhibited significant differences in new bone formation areas (NBFAs) (0.54 ± 0.004 mm2 for Ti and 0.65 ± 0.003 mm2 for the composite). After 6 weeks, there was new bone formation with osteocytes around the pure titanium implants (NBFA of 2.44 mm2) and osteoid maturation with the observation of reversal lines around the composite implants (NBFA of 2.89 mm2). The developed Ti‐TiB2 material was biocompatible and demonstrated superior bone growth compared to that of the pure Ti materials after 2 and 6 weeks.

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