Effect of low‐level laser therapy and oxytocin on osteoporotic bone marrow‐derived mesenchymal stem cells

Fallahnezhad, Somaye; Piryaei, Abbas; Darbandi, Hasan; Amini, Abdollah; Ghoreishi, Seyed Kamran; Jalalifirouzkouhi, Reza; Bayat, Mohammad

doi:10.1002/jcb.26265

Cited by 29 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nineteen articles investigated osteogenic & angiogenic markers, and growth factors that consist of five in vitro (Ateş et al, 2017;Chen et al, 2018;Peat et al, 2017;Saracino et al, 2009;Wang et al, 2016), and eleven in vivo studies (Table 1) (Fallahnezhad et al, 2018;Kesler et al, 2011;Magri et al, 2015;Omasa et al, 2012;Park et al, 2015;Patrocínio-Silva et al, 2014;Sella et al, 2015;Tim et al, 2014Tim et al, , 2015Tim et al, , 2016Wang et al, 2018), and three clinical trials (Table 2) (Domínguez et al, 2015;Mozzati et al, 2011Mozzati et al, , 2012. In two studies, neodymium-doped yttrium aluminum garnet (Nd:YAG) laser were applied (Kesler et al, 2011;Peat et al, 2018), and one study used HeeNe laser (Fallahnezhad et al, 2018); In other studies galliumaluminum-arsenide (GaeAleAs) laser used (Ateş et al, 2017;Magri et al, 2015;Omasa et al, 2012;Park et al, 2015;Saracino et al, 2009;Sella et al, 2015;Tim et al, 2014Tim et al, , 2015Tim et al, , 2016Wang et al, 2016). In addition, one investigation utilized LED array and filtered lamp for photobiomodulation (Wang et al, 2016).…”

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

“…Energy density also encompass a wide range from 1.5 J/cm2 (Ateş et al, 2017) to 1000 J/cm2 (Tim et al, 2015); However, in most of articles its amount was less than 5 J/cm2 (Ateş et al, 2017;Magri et al, 2015;Saracino et al, 2009;Tim et al, 2016;Wang et al, 2016). In vitro studies used pre-osteoblasts, osteoblasts, mesenchymal and adipose derived stem cells (Ateş et al, 2017;Fallahnezhad et al, 2018;Peat et al, 2018;Saracino et al, 2009;Wang et al, 2016). All in vivo investigations used rats as their animal model (Chen et al, 2018;Kesler et al, 2011;Magri et al, 2015;Omasa et al, 2012;Park et al, 2015;Sella et al, 2015;Tim et al, 2014Tim et al, , 2015Tim et al, , 2016Wang et al, 2018) and bone defect at tibia bone was the most common one (Kesler et al, 2011;Magri et al, 2015;Tim et al, 2014Tim et al, , 2015Tim et al, , 2016.…”

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

“…Seven studies used immunohistochemistry (IHC) analysis. One article applied Western blot (Park et al, 2015) and two used enzymelinked immunosorbent assay (Fallahnezhad et al, 2018;Peat et al, 2018) and one study used micro array hybridization as their assessment method (Tim et al, 2015). Angiopoietin 2 (ANGPT-2), bone morphogenetic protein (BMP) À1, À2, À4, À7, Collagen type I (COL1), fibroblast growth factor (FGF) À2, À3, À5, À7, À14, À15, À17, À22, osterix (OSX), osteocalcin (OCN), osteopontin (OPN), osteonectin (Chang et al, 2010, peroxisome proliferators-activated receptor (PPAR), receptor activator of nuclear factor kappa-В ligand (RANKL), runt-related transcription factor (RUNX e 2), transforming growth factor beta (TGF b), insulin-like growth factor (IGF), von Willebrand factor (vWF), and vasculoendothelial growth factor (VEGF) were studied in these articles (Ateş et al, 2017;Chen et al, 2018;Kesler et al, 2011;Magri et al, 2015;Omasa et al, 2012;Park et al, 2015;Peat et al, 2018;Saracino et al, 2009;Sella et al, 2015;Tim et al, 2014Tim et al, , 2015Tim et al, , 2016Wang et al, 2016Wang et al, , 2018.…”

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Molecular impacts of photobiomodulation on bone regeneration: A systematic review

Hosseinpour

Fekrazad

Arany

et al. 2019

Progress in Biophysics and Molecular Biology

View full text Add to dashboard Cite

Photobiomodulation (PBM) encompasses a light application aimed to increase healing process, tissue regeneration, and reducing inflammation and pain. PBM is specifically aimed to modify the expression of cellular molecules; however, PBM impacts on cellular and molecular pathways especially in bone regenerative medicine have been investigated in scattered different studies. The purpose of the current study is to systematically review evidence on molecular impact of PBM on bone regeneration. A comprehensive electronic search in Medline, Scopus, EMBASE, EBSCO, Cochrane library, web of science, and google scholar was conducted from January 1975 to October 2018 limited to English language publications on administrations of photobiomodulation for bone regeneration which evaluated biological factors. In addition, hand search of selected journals was done to retrieve all articles. This systematic review was performed based on PRISMA guideline. Among these studies, five articles reported in vitro results, twelve articles were in vivo, and three of them were clinical trials. The data tabulated according to the type of markers (osteogenic markers, angiogenic markers, growth factors, and inflammation mediators). PBM's effects depend on many parameters which energy density is more important than the others. PBM can significantly enhance expression of osteocalcin, collagen, RUNX-2, vascular endothelial growth factor, bone morphogenic proteins, and COX-2. Although since the heterogeneity of the studies and their limitations, an evidence-based decision for definite therapeutic application of PBM is still unattainable, the findings of our review can help other researchers to ameliorate their study design and elect more efficient approach for their investigation.

show abstract

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

Section: Osteogenic Markers Angiogenic Markers and Growth Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Molecular impacts of photobiomodulation on bone regeneration: A systematic review

Hosseinpour

Fekrazad

Arany

et al. 2019

Progress in Biophysics and Molecular Biology

View full text Add to dashboard Cite

show abstract

“…Oxytocin is used in regenerative medicine because of its beneficial characteristics, which improve vascular and metabolic functions and are shown to be cardioprotective in obesity and diabetes [22,26,39,40]. Studies show that oxytocin has anti-inflammatory activity, increases stem cell resistance to oxidative stress, and promotes migration, proliferation, and differentiation of mesenchymal stem cells [39,[41][42][43][44][45][46]. The use of oxytocin together with stem cells has a regulatory effect on growth and differentiation [47][48][49][50][51][52].…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord

Gil-Kulik

Chomik

Krzyżanowski

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The paper presents an evaluation of the POU5F1 gene expression in mesenchymal stem cells derived from Wharton’s jelly within the umbilical cord, collected from 36 patients during labor. The study is the first one to show that the expression of POU5F1 in mesenchymal stem cells has been dependent on maternal age, birth order, route of delivery, and use of oxytocin. Our research proves that the POU5F1 gene expression in mesenchymal stem cells decreases with each subsequent pregnancy and delivery. Wharton’s jelly stem cells obtained from younger women and during their first delivery, as well as patients treated with oxytocin, show higher POU5F1 gene expression when compared with the subsequent deliveries. This leads to a conclusion that they are characterized by a lower level of differentiation, which in turn results in their greater plasticity and greater proliferative potential. Probably, they are also clinically more useful.

show abstract

“…5 Wound healing is a complicated process that involves clot formation, inflammation, granulation, epithelialization, and remodeling. 7,8 Studies on wound healing have investigated the effect of oxygen therapy, [9][10][11] biomechanics, 12 radiotherapy and medical pomades. 13 Low-level laser therapy (LLLT) is a good modality for wound healing.…”

Section: Introductionmentioning

confidence: 99%

Combined Effect of Low-Level Laser Treatment and Levothyroxine on Wound Healing in Rats With Hypothyroidism

et al. 2018

Self Cite

View full text Add to dashboard Cite

Please cite this article as follows: Firouzi A, Norozian M, Amini A, Abdollahifar MA, Abbaszadeh HA, Fadaei Fathabadi F. Combined effect of low-level laser treatment and levothyroxine on wound healing in rats with hypothyroidism. AbstractIntroduction: Hypothyroidism delays wound healing by reducing the synthesis of keratinocytes, fibroblast cells, and collagen. Methods for enhancement of wound healing include laser therapy and hormone therapy. The current study evaluated the combined effect of laser and levothyroxine therapy to cure wounds in male rats with hypothyroidism. Methods: Sixty male Wistar rats were randomly divided into 5 groups: (1) healthy controls;(2) controls with hypothyroidism; (3) hypothyroidism + laser treatment; (4) hypothyroidism + levothyroxine treatment; (5) hypothyroidism + laser + levothyroxine treatment. Hypothyroidism was induced by dissolving 4 mg of methimazole in 100 mL of drinking water daily for 28 days. After hypothyroidism had been confirmed, a longitudinal incisional wound was created on the dorsal rib cages of the rats. The wounds that received laser treatment were divided into 12 sections and treated at 810 nm wavelength and 0.2 J/cm 2 of energy density for 200 seconds. Levothyroxine was administrated in doses of 20 µg/kg/d i.p. All groups were divided into 3 subgroups for testing on days 4, 7 and 14. Samples were collected in all the subgroups. Results: The results showed that hypothyroidism reduced fibrous tissue volume, fibroblasts, and basal cell numbers. The combined effect of laser and levothyroxine improved all parameters. Conclusion: Combined laser and levothyroxine treatment showed the best effect on wound healing and accelerated the closure of the wounds.

show abstract

Effect of low‐level laser therapy and oxytocin on osteoporotic bone marrow‐derived mesenchymal stem cells

Cited by 29 publications

References 50 publications

Molecular impacts of photobiomodulation on bone regeneration: A systematic review

Molecular impacts of photobiomodulation on bone regeneration: A systematic review

Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord

Combined Effect of Low-Level Laser Treatment and Levothyroxine on Wound Healing in Rats With Hypothyroidism

Contact Info

Product

Resources

About