Effect of Low Level Cadmium Exposure on Superoxide Dismutase Activity in Rat

Ogunrinola, Olabisi; Wusu, Adedoja Dorcas; Fajana, O.O.; Olaitan, Samuel; Smith, Zainab O.; Bolaji, Abdul-Rahman I.

doi:10.4314/tjpr.v15i1.16

Cited by 18 publications

(12 citation statements)

References 15 publications

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“…Our results show that SOD, CAT (Figure 3), GSH-Px and GR activity (Figure 4) were lower in the erythrocytes of Cd-treated rats. The same depletion of enzymes was recorded in some organs of Cd-treated rats (Ogunrinola et al, 2016; Oyinloye et al, 2016a, 2016b). In physiological condition, SOD catalyses the conversion of O 2 • − into H 2 O 2 and O 2 .…”

Section: Discussionsupporting

confidence: 76%

Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats

et al. 2017

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Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q (CoQ) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ (20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group). After 24 h, Cd was injected intraperitoneally (0.4 mg/kg b.w.) and 1 day after, animals were sacrificed. Acute Cd intoxication caused significant changes in haematological and biochemical parameters and altered the glutathione cycle, leading to the formation of lipid peroxidation, while the concentrations and activities of antioxidants (vitamins C and E, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were decreased. CoQ and/or VE significantly maintained these values to near-normal levels, afforded additional protection by reducing lipid peroxidation and improved the levels of antioxidants in the blood. Plasma CoQ and VE levels negatively correlated with oxidative damage parameters while positively correlated with antioxidative defence parameters. Regarding their effects, CoQ and VE were in synergistic interaction. The present study suggested that CoQ and VE combination may be beneficial in protecting from Cd-induced haematotoxicity and may be used as a preventive against acute Cd intoxication of exposed people.

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Section: Discussionsupporting

confidence: 76%

Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats

et al. 2017

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“…Diminished activities of SOD, GPx, and CAT have been reported in both occupational studies (Babu et al, 2006; Bizoń and Milnerowicz, 2014; Moitra et al, 2014; Nzengue et al, 2011) and in different tissues of Cd- treated rats (Ognjanović et al, 2010; Ogunrinola et al, 2016; Oyinloye et al, 2016; Paunović et al, 2017). The interaction between Cd and essential trace elements could be one of the reasons for decreased activity of antioxidant enzymes (Ognjanović et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial

et al. 2018

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Recently, there is a growing interest for the use of antioxidants as a preventive agent against cadmium (Cd) intoxication. The current study aimed to investigate the effects of dietary coenzyme Q10 supplementation on oxidative stress and antioxidant enzymes activity in Cd-exposed glazers. In a randomized, double-blind, placebo-controlled 2-month crossover clinical trial, coenzyme Q10 (60 mg twice daily) or placebo was administrated to 40 male glazers occupationally exposed to Cd. The subjects were randomly assigned to the placebo and coenzyme Q10 groups ( n = 20 in each group). Total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) as well as malondialdehyde (MDA) in the serum of glazers were measured at baseline and at the end of both intervention phases. The primary outcomes were the changes in serum levels of MDA, TAC and the activities of SOD, CAT, and GPx during administration with coenzyme Q10 versus placebo. Compared with placebo, treatment to coenzyme Q10 was associated with a significant reduction in serum MDA levels ( p < 0.001) While, there was no significant effect on the serum TAC levels ( p = 0.096). Also, the activity antioxidant enzymes of SOD ( p < 0.001) and GPx ( p = 0.003) were significantly higher and the CAT activity ( p < 0.001) was lower after 2-month coenzyme Q10 administration compared with placebo. Data demonstrated that coenzyme Q10 supplementation at a dose of 60 mg (twice daily) is effective in reducing oxidative stress marker level (MDA) and improving antioxidant enzymes activity in glazers exposed to Cd. However, further research is needed to assess coenzyme Q10 as a possible dietary intervention in Cd-exposed workers. Trial Registration: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).

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“…In this case, SOD, CAT, and GPx activity in yeast cells treated with Cd 2+ (without extract) were significantly higher by ~53%, ~112%, ~24%, respectively. The increase in antioxidant enzyme activity caused by cadmium was also observed in wild strain of S. cerevisiae (Muthukumar & Nachiappan ), rats brain (Kaczmarek‐Wdowiak et al, ), liver of zebrafish (Wang et al, ), human neural cells (Huang et al, ), and blood, liver and brain of rats (Ogunrinola et al, ).…”

Section: Resultsmentioning

confidence: 99%

Onion skin extract as a protective agent against oxidative stress in Saccharomyces cerevisiae induced by cadmium

Piechowiak

Balawejder

2019

J Food Biochem

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Onion skin extract is a source of bioactive compounds demonstrating a high antioxidant activity. The purpose of this research was to investigate the effect of onion skin extract at the level of oxidative stress markers in Saccharomyces cerevisiae exposed to cadmium. The generation of reactive oxygen species (ROS), antioxidant enzymes activity, total content of glutathione, and the level of lipid peroxidation in yeast cells were determined. Research showed that onion skin extract protected the yeast cells from the occurrence of oxidative stress induced by cadmium. Cells treated with onion skin extract and cadmium were characterized by lower generation of ROS, antioxidant enzymes activity, lipid peroxidation, and higher level of glutathione content than cells treated with cadmium only. However, the protective effect was dependent on the onion skin extract concentration in yeast medium. Practical applications The presented studies are of comprehensive character regarding antioxidant properties of the onion skin extract, using Saccharomyces cerevisiae as a model organism. The research results give the opportunity to conduct further research on the use of onion skin extract in functional food or dietary supplements production, as a cellular protector against negative consequence of oxidative stress. It should also be mentioned that the major research material was onion skin which is a troublesome waste material for onion producers. Consequently, the study result will, to a certain extent provide an opportunity to increase interest in the problem of rational use of the waste material, according to a sustainable development idea.

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Effect of Low Level Cadmium Exposure on Superoxide Dismutase Activity in Rat

Cited by 18 publications

References 15 publications

Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats

Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats

Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial

Onion skin extract as a protective agent against oxidative stress in Saccharomyces cerevisiae induced by cadmium

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