Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial

Abstract

Recently, there is a growing interest for the use of antioxidants as a preventive agent against cadmium (Cd) intoxication. The current study aimed to investigate the effects of dietary coenzyme Q10 supplementation on oxidative stress and antioxidant enzymes activity in Cd-exposed glazers. In a randomized, double-blind, placebo-controlled 2-month crossover clinical trial, coenzyme Q10 (60 mg twice daily) or placebo was administrated to 40 male glazers occupationally exposed to Cd. The subjects were randomly assigned to the placebo and coenzyme Q10 groups ( n = 20 in each group). Total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) as well as malondialdehyde (MDA) in the serum of glazers were measured at baseline and at the end of both intervention phases. The primary outcomes were the changes in serum levels of MDA, TAC and the activities of SOD, CAT, and GPx during administration with coenzyme Q10 versus placebo. Compared with placebo, treatment to coenzyme Q10 was associated with a significant reduction in serum MDA levels ( p < 0.001) While, there was no significant effect on the serum TAC levels ( p = 0.096). Also, the activity antioxidant enzymes of SOD ( p < 0.001) and GPx ( p = 0.003) were significantly higher and the CAT activity ( p < 0.001) was lower after 2-month coenzyme Q10 administration compared with placebo. Data demonstrated that coenzyme Q10 supplementation at a dose of 60 mg (twice daily) is effective in reducing oxidative stress marker level (MDA) and improving antioxidant enzymes activity in glazers exposed to Cd. However, further research is needed to assess coenzyme Q10 as a possible dietary intervention in Cd-exposed workers. Trial Registration: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).

Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials

“…The range of mean age among these participants was from 17.2 to 79.2 years. Five studies only contained male subjects in healthy status or special occupation [ 32 , 33 , 34 , 35 , 36 ]. Conversely, there were two studies conducted among women only [ 37 , 38 ].…”

“…Taking CoQ10 for 8 weeks also significantly changed the levels of them except SOD. However, it is worthy to note there were only two RCTs that included evaluating the effect of 8-week CoQ10 supplementation on SOD levels [ 32 , 63 ]. Only three RCTs conducted CoQ10 intervention for more than 12 weeks [ 55 , 56 , 62 ]; hence we could not conclude that longer intervention time would bring about better antioxidant effects of CoQ10 yet.…”

Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population

“…MDA is the best product to evaluate lipid peroxidation ( Sepidarkish et al, 2020 ), and it has been shown that CoQ10 can prevent lipid peroxidation and reduce MDA in vitro and in vitro ( Talevi et al, 2013 ; Gholnari et al, 2018 ; Hormozi et al, 2019 ). CoQ10 supplementation may reduce MDA levels via several mechanisms.…”

Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene

“…A number of studies have suggested that long-term occupational exposure to a low-level mixture of VOCs, including benzene, toluene, and xylene, is associated with decreased TAC levels in serum (Maksoud et al, 2018; Verma et al, 2017; Zhao et al, 2008). The serum TAC offers a complete panorama of the function of antioxidant system in the body under oxidative stress (Hormozi et al, 2018a). In the present study, although there was a small decrease in serum TAC levels of PWs compared to that of the control subjects, these effects were not statistically significant ( p =.088).…”