Effect of long term intake of aspartame on antioxidant defense status in liver

Abhilash, M. R.; Paul, M. V. Sauganth; Varghese, Mathews Valuparampil; Nair, R. Harikumaran

doi:10.1016/j.fct.2011.02.019

Cited by 83 publications

(60 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies have associated artificial sweeteners, Aspartame, with health disorders such as hepatotoxicity (Abhilash et al, 2011) and cancer (Whitehouse et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Stevia rebaudiana and Aspartame on hepato-renal function of diabetic rats: Biochemical and Histological Approaches

2017

J App Pharm Sci

View full text Add to dashboard Cite

Diabetes mellitus is a chronic syndrome affecting many systems of the body and may be considered as a leading cause of death globally. To compare the efficacy of Stevia rebaudiana and Aspartame on hepato-renal functions, sixty adult male albino rats were divided into 6 groups; control, Stevia, Aspartame, diabetic, diabetic-treated with Stevia and diabetic-treated with Aspartame. Food consumption, body weight, blood glucose, serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine levels were determined. Hepatic malondialdehyde (MDA), glutathione (GSH) and bcl-2 levels were assessed as well as histological examination for liver and kidney sections were performed. Treatment of diabetic rats with Stevia leaf extract or Aspartame significantly lowered food consumption and serum blood glucose. Serum blood glucose was significantly decreased by 38% with Stevia treatment and 50% with Aspartame. Stevia treatment of diabetic rats significantly lowered the serum level of ALT by 62%, AST by 57%, ALP by 41%, urea by 16% and creatinine by 65%. Hepatic MDA was reduced by 50% in diabetic group treated with Stevia and hepatic GSH and Bcl-2 levels were significantly elevated. In contrast, Aspartame did not change these parameters. Histopatholgically, diabetic rats treated with Stevia showed improvement of liver and renal tissues, while Aspartame treatment augmented alloxan induced tissue destruction. Aspartame was more effective hypoglycemic agent than Stevia in diabetic rats but Stevia showed protective effects on the liver and kidney functions. Stevia rebaudiana may be therapeutically beneficial as hepato-renal protective agent for those suffering from diabetes mellitus.

show abstract

“…Some studies have associated artificial sweeteners, Aspartame, with health disorders such as hepatotoxicity (Abhilash et al, 2011) and cancer (Whitehouse et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Stevia rebaudiana and Aspartame on hepato-renal function of diabetic rats: Biochemical and Histological Approaches

2017

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…In contrary, this research also mentioned that aspartame acted as a chemical stressor and raised oxidative stress leading to inflammation (Choudhary and Devi 2015). Other studies also demonstrated that aspartame consumption could cause an increment of fat and body mass (Collison et al, 2012;Feijo et al, 2013), liver damage, and non-alcoholic fatty liver disease (NAFLD) (Abhilash et al, 2011). A study by Yang (2010) proposed that the sweet response produced after consuming artificial sweetener could increase the appetite and reduce satiety, which finally led to obesity development.…”

Section: Introductionmentioning

confidence: 93%

The effect of sugar and artificial sweetener on molecular markers of metabolic syndrome: a mice study

Subali¹,

Silo²,

Listyani³

et al. 2017

Food Res.

View full text Add to dashboard Cite

The usage of aspartame, as one of the most widely used sweetener, has been approved in many types of food products. Moreover, many studies have proven that replacing sugar with aspartame would contribute favorable effects on several health parameters; such as, body weight, blood glucose level, and inflammatory status. In this experiment, we examined the effects of aspartame consumption on some biomarkers; which potentially acted as early signals for a personal metabolic status. This study was aimed to investigate the effect of aspartame on the expression of a number of molecular markers related with appetite regulation (fto), fat accumulation markers (fabp4 and alt2) and inflammation marker (tnf-α) in Sprague Dawley rats. The population of Clostridium coccoides was also observed to give an insight about the effect of sweetener consumption on gut microbiota profiles. 15 healthy, male, eight-weeks old Sprague-Dawley rats were fed a standard diet and divided into 3 groups (n=5 for each): water only, sucrose (30% b/v), and aspartame (0.15% b/v). Body weight was measured weekly and blood glucose measurement was carried out on day 1 and 40. At the end of the experiment, all rats were euthanized and blood was collected from the vein. The liver, brain, and visceral adipose tissue were excised, weighed, and grinded with liquid nitrogen. Feces samples were collected on day 0 and 40. At the end of our experimental period; the body weight, liver weight, and blood glucose level of sucrose-treated rats were significantly higher (p <0.05) than aspartame and control group. Sucrose showed the lowest level of fto gene expression; yet, the fto gene expression in aspartame group was still lower than the control group. Expression of several genes considered as metabolic syndrome-related biomarkers were measured (fabp4, alt2, and tnf-α); and our data demonstrated that sucrose treatment gave the highest increase in expression level of those genes; while aspartame treatment showed much lower values. Furthermore, sucrose also caused a significant reduction in C. coccoides population; while, the C. coccoides population in aspartame group did not differ significantly compared to the control group.

show abstract

“…A study assaying the aspartame intake under a similar pattern of the society feeding relating to the WHO/FAO recommended limits has not been reported (Frey, 1976;Knopp et al, 1976;Ishii et al, 1981;Stegink et al, 1983;Shahangian et al, 1984;Stegink, 1987;Colagiuri et al, 1989;Gupta et al, 1989;Butchko et al, 2002;Gougeon et al, 2004;Roberts, 2004;de la Hunty et al, 2006;Soffritti et al, 2006;Gombos et al, 2007;Magnuson et al, 2007;Soffritti et al, 2007;Roberts, 2008;Anton et al, 2010;Abhilash et al, 2011;Aune, 2012;Schernhammer et al, 2012;Feijó et al, 2013;Palmnäs et al, 2014). Therefore, the aim of this study was to evaluate the nutritional and biochemical effects of aspartame in Wistar rats consuming a fat plus sucrose enriched diet relating to the WHO/FAO values.…”

Section: Introductionmentioning

confidence: 99%

“…However, other studies have been demonstrated that the consumption of aspartame may cause deleterious effects such as hepatocellular injury, carcinogenic effects and systemic hypertension (Roberts, 2004;Soffritti et al, 2006;Gombos et al, 2007;Abhilash et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Martinez-Morales¹,

Maldonado‐Cervantes²,

Isiordia-Espinoza³

et al. 2015

JEBAS

View full text Add to dashboard Cite

The present study evaluates the effect of aspartame intake in rats under a diet mimicking the trends of fat consumption in the society. The composition of the experimental diet was within the recommended human limits except the saturated fat amount supplying from coconut fat. Rats under the experimental diet showed an increase in the body weight, transitory increase in the blood pressure and in plasma values of glucose and triglycerides alongside a transitory reduction in plasma urea versus the standard group. Rats under the experimental diet plus aspartame intake (54.8 ± 7.3 mg/kg bw/day) did not show any increase of body weight and in plasma values of glucose and triglycerides while showed an improvement in the plasma value of urea with respect the group under only the experimental diet. However, the aspartame group showed a more maintained increase of blood pressure. In conclusion, experimental diet produces negative effects on cardiovascular risk factors of the rats while the aspartame intake under the experimental feeding had mixed effects on the cardiometabolic factors of the animals.

show abstract

Effect of long term intake of aspartame on antioxidant defense status in liver

Cited by 83 publications

References 34 publications

Comparative Effects of Stevia rebaudiana and Aspartame on hepato-renal function of diabetic rats: Biochemical and Histological Approaches

Comparative Effects of Stevia rebaudiana and Aspartame on hepato-renal function of diabetic rats: Biochemical and Histological Approaches

The effect of sugar and artificial sweetener on molecular markers of metabolic syndrome: a mice study

Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Contact Info

Product

Resources

About