Effect of Local Application of Cidofovir on the Control of Recurrences in Recurrent Laryngeal Papillomatosis

Pontes, Paulo; Avelino, Melissa Ameloti Gomes; Pignatari, Shirley Shizue Nagata; Weckx, Luc Louis Maurice

doi:10.1016/j.otohns.2005.10.060

Cited by 31 publications

(42 citation statements)

References 11 publications

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“…A number of adjuvant therapies have been proposed; however, in most cases, a cure is not achieved, only palliation. Cidofovir is one of the most common adjuvant drugs currently used in the treatment of RLP 5 and, despite the favorable results demonstrated in most studies, [13][14][15][16][17][18][19][20] administration and dosage regimens, as well as safety of cidofovir, are yet to be established in the treatment of this disease.…”

Section: Patientmentioning

confidence: 99%

“…Doses between 2.5 and 30 mg of cidofovir are reported in the literature, injected intralesionally or in the region of papilloma excision. Some studies have demonstrated favorable results, that is, remission or decreased severity of disease in most patients treated with cidofovir, [13][14][15][16][17][18][19][20] whereas other studies have not observed a significant improvement. 21,22 objectIve To evaluate the efficacy of local application of cidofovir in association with surgical treatment of RLP in children.…”

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confidence: 99%

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Aplicação local de cidofovir como tratamento adjuvante na papilomatose laríngea recorrente em crianças

Pontes

Weckx

Pignatari

et al. 2009

Rev. Assoc. Med. Bras.

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Section: Patientmentioning

confidence: 99%

mentioning

confidence: 99%

Aplicação local de cidofovir como tratamento adjuvante na papilomatose laríngea recorrente em crianças

Pontes

Weckx

Pignatari

et al. 2009

Rev. Assoc. Med. Bras.

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“…However, some recent studies report that interferon sloha and antiviral agents such as cidofovir show promising results in the treatment of RLP [12][13][14]. RRLP is known to undergo malignant transformation.…”

Section: Discusionmentioning

confidence: 99%

“…It is thought to be associated with extrinsic factors such as smoking and radiation therapy. However, some cases have been reported in patients without these risk factors [14].…”

Section: Discusionmentioning

confidence: 99%

Pulmonary Manifestations of Juvenile Laryngotracheal Papillomatosis: Case Report and Literature Review

Škarda¹,

Tichà²,

Tich³

et al. 2009

TOPATJ

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Abstract:In the present report, we report on a rare case of tracheobronchopulmonary spread of childhood recurrent laryngeal papillomatosis without ana association to prior HPV infection, in a 39-year-old female patient.Recurrent laryngeal papillomatosis (RRLP) is a rare benign disease seen in children and a fewcases are reported in adults. Although RRLP is histologically a benign proliferation of stratified squamous epithelium and is usually limited to the larynx its spread to the tracheobronchial tree occurs in 2% to 29% of cases and to the pulmonary parenchyma in less than 7% of cases. CASE REPORTA woman 39 years of age with bilateral focal lesions of the lung. Wedge excision of the lesion in the right lung filled with a purulent secretion. Macroscopic AppearanceThe lung tissue, 42x30x20 mm in size had multiple yellowish and graysh lesions of varying size from 2-15 mm with purulent content in the center of the largest lesion. HISTOLOGICAL FINDINGSA-E: In all tisuue sections, the findings were identical, as follows: in lung parenchyma several cavitated lesions lined with sheet-like solid masses of squamous proliferations or flat squamous epithelium could be observed. Similar free epithelial sheets could also be seen in the alveolár spaces without any relationship to the above-mentioned cysts. The epithelium showed dyskeratotic changes with evidence of clear maturation without mitoses or dysplastic changes. The given lesion had oval margins without evidence of invasive growth. Keratin and focal spumoid macrophages could be detected in the alveolar spaces and in the lumen of the lesion (Figs. 1, 2). Due to the peculiarity of the histological picture and vague information from the clinician, we searched the patient database and found that the patient had recurrent laryngeal papillomatosis.The above histological picture is compatible with pulmonary manifestation of juvenile laryngeotracheal papillomatosis or pulmonary parenchymal papillomatosis.*Address correspondence to this author at the Department of Pathology and Laboratory of Molecular Pathology, Medical Faculty, Palacky University, Olomouc, Czech Republic; E-mail: jojos@email.cz § Both authors contributed equally to the study. Fig. (1). In lung parenchyma several cavitated lesions lined with sheet-like solid masses of squamous proliferations or flat squamous epithelium could be observed. Similar free epithelial sheets could also be seen in the alveolar spaces without any relationship to the above-mentioned cysts. Fig. (2). The epithelium showed dyskeratotic changes with evidence of clear maturation without mitoses or dysplastic changes. The given lesion had oval margins without evidence of invasive growth. Keratin and focal spumoid macrophages could be detected in the alveolar spaces and in the lumen of the lesion 100x HE.

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“…They are also used to treat granulation tissue and granulomas of the vocal fold 1, 4. Laryngeal injection of cidofovir, an antiviral agent, has also been described as an adjunctive treatment for controlling recurrent laryngeal papillomatosis 5, 6. Furthermore, emerging applications are forthcoming, such as the use of Avastin (Genentech, Inc., San Francisco, CA) for laryngeal papilloma and growth factors for treating age‐related vocal fold changes.…”

Section: Introductionmentioning

confidence: 99%

Slow‐release nanoparticle‐encapsulated delivery system for laryngeal injection

et al. 2010

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Effect of Local Application of Cidofovir on the Control of Recurrences in Recurrent Laryngeal Papillomatosis

Abstract: C-4.

Cited by 31 publications

References 11 publications

Aplicação local de cidofovir como tratamento adjuvante na papilomatose laríngea recorrente em crianças

Aplicação local de cidofovir como tratamento adjuvante na papilomatose laríngea recorrente em crianças

Pulmonary Manifestations of Juvenile Laryngotracheal Papillomatosis: Case Report and Literature Review

Slow‐release nanoparticle‐encapsulated delivery system for laryngeal injection

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