Effect of light colour temperature and intensity on τhε behaviour of male C57CL/6J mice

Kapogiannatou, Aspasia; Paronis, Efthymios; Paschidis, Konstantinos; Polissidis, Alexia; Kostomitsopoulos, Nikolaos

doi:10.1016/j.applanim.2016.08.005

Cited by 29 publications

(28 citation statements)

References 26 publications

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“…Additionally, mice are considered insensitive to red light (Peirson et al, 2018). The intensity and color of light are additional variables that contribute to changes in behavior and stress (McReynolds et al, 1967;Kapogiannatou et al, 2016). Therefore, the use of dim red light in our studies is expected to minimally affect mouse behavior compared to bright light stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…Behavioral tests were performed under indirect red lighting by video camera. Indirect red lighting was used to better assess parameters of anxiety without influencing mouse behavior (i.e., reduced activity in the open field test) and stress, which has been observed with direct light or bright light stimuli (McReynolds et al, 1967;Kapogiannatou et al, 2016;Peirson et al, 2018). Investigators were blind to mice groups when conducting behavioral analyses.…”

Section: Behavioral Testingmentioning

confidence: 99%

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Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety

et al. 2020

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Anxiety disorders are the most common mental illness in the U.S. and are estimated to consume one-third of the country's mental health spending. Although anxiolytic therapies are available, many patients exhibit treatment-resistance, relapse, or substantial side effects. An urgent need exists to explore the underlying mechanisms of chronic anxiety and to develop alternative therapies. Presently, we identified dihydromyricetin (DHM), a flavonoid that has anxiolytic properties in a mouse model of isolation-induced anxiety. Socially isolated mice demonstrated increased anxiety levels and reduced exploratory behavior measured by elevated plus-maze and open-field tests. Socially isolated mice showed impaired GABAergic neurotransmission, including reduction in GABA A receptormediated extrasynaptic tonic currents, as well as amplitude and frequency of miniature inhibitory postsynaptic currents measured by whole-cell patch-clamp recordings from hippocampal slices. Furthermore, intracellular ATP levels and gephyrin expression decreased in anxious animals. DHM treatment restored ATP and gephyrin expression, GABAergic transmission and synaptic function, as well as decreased anxiety-like behavior. Our findings indicate broader roles for DHM in anxiolysis, GABAergic neurotransmission, and synaptic function. Collectively, our data suggest that reduction in intracellular ATP and gephyrin contribute to the development of anxiety, and represent novel treatment targets. DHM is a potential candidate for pharmacotherapy for anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Behavioral Testingmentioning

confidence: 99%

Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety

et al. 2020

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“…Previous human studies reported enhancement of sympathetic nerve activity and the arousal level and suppression of melatonin secretion by increasing the color temperature [32]. Animal studies also reported an association between higher frequencies of stress behaviors and an increase in color temperature [24]. This study linked an increase in color temperature to higher c-Fos expression for each light source.…”

Section: Discussionmentioning

confidence: 53%

“…Deguchi et al [23] reported a contingent negative variation (CNV) response from electroencephalogram (EEG) of 11 human participants and found that a higher color temperature activated the reticular activating system more than a lower color temperature. Results from mice studies associated a higher color temperature with an increased stress and anxiogenic response [24]. These studies indicate that further research on light irradiation and brain function is needed to examine color temperature in more depth.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Light Sources on Neural Activity of the Paraventricular Nucleus in the Hypothalamus

Yokoyama

Chang

Anzai³

et al. 2019

Medicina

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Background and Objectives: Physical function is influenced by light irradiation, and interest in the influence of light irradiation on health is high. Light signals are transmitted from the retina to the suprachiasmatic nucleus (SCN) via the retinal hypothalamic tract as non-image vision. Additionally, the SCN projects a nerve to the paraventricular nucleus (PVN) which acts as a stress center. This study examined the influences of three different light sources on neural activity in the PVN region using two different color temperatures. Materials and Methods: Experiments were conducted using twenty-eight Institute of Cancer Research (ICR) mice (10 week old males). Three light sources were used: (1) organic light-emitting diode (OLED) lighting, (2) LED lighting, and (3) fluorescent lighting. We examined the effects of light irradiation from the three light sources using two different color temperatures (2800 K and 4000 K). Perfusion was done 60 min after light irradiation, and then the brain was removed from the mouse for an immunohistochemistry analysis. c-Fos was immunohistochemically visualized as a marker of neural activity in the PVN region. Results: The number of c-Fos-positive cells was found to be significantly lower under OLED lighting and LED lighting conditions than under fluorescent lighting at a color temperature of 2800 K, and significantly lower under OLED lighting than LED lighting conditions at a color temperature of 4000 K. Conclusions: This study reveals that different light sources and color temperatures alter the neural activity of the PVN region. These results suggest that differences in the light source or color temperature may affect the stress response.

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“…Color temperature is often measured in Kelvins (K); according to color temperature, lightning is classified into the three following groups: Warm (about 2900 K), White (about 4200 K) and Cool (about 6000 K) (Kapogiannatou et al, 2016). Hence, for the research, ten sample advertisements of which 5 were warm color temperature (3000 K) and 5 were cool color temperature (6000 K) were created with the female celebrity spokesperson and ten sample advertisements of which 5 were warm color temperature (3000 K) and 5 were cool color temperature (6000 K) were created with the male celebrity spokesperson (see Figure no.…”

Section: Methodsmentioning

confidence: 99%

Relationship between Spokesperson’s Gender and Advertising Color Temperature in a Framework of Advertising Effectiveness

Pilelienė¹,

Grigaliūnaitė²

2017

Scientific Annals of Economics and Business

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Advertising spokesperson is one of the undeniably important factors affecting advertising effectiveness. However, advertising spokesperson has to have some particular features to be effective. Various previous researches resulted in determination of different features of advertising spokesperson and their effectiveness; i.e. type of a spokesperson (celebrity vs. a regular person); gender and race of a spokesperson; etc. were found to have an impact on the spokesperson's effectiveness. However, the research on the impact of shooting color temperature on its effectiveness is still scarce. Moreover, an assumption can be made that color temperature might cause a different effect depending on advertising spokesperson's gender. The aim of this paper is to fill this gap by analyzing the relationship between spokesperson's gender and advertising color temperature in a framework of advertising effectiveness. Neuromarketing research methods were applied to meet the aim and to determine the guidelines for its usage in advertising.

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Effect of light colour temperature and intensity on τhε behaviour of male C57CL/6J mice

Cited by 29 publications

References 26 publications

Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety

Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety

Effects of Different Light Sources on Neural Activity of the Paraventricular Nucleus in the Hypothalamus

Relationship between Spokesperson’s Gender and Advertising Color Temperature in a Framework of Advertising Effectiveness

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