Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets1

Wang, Y.; Shan, Tizhong; Xu, Zhenghao; Liu, J.; Feng, Jia-Wei

doi:10.2527/jas.2005-544

Cited by 75 publications

(55 citation statements)

References 32 publications

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“…This result also shows that the activity of lactoferrin in vivo may be similar to that demonstrated by Oguchi et al [9] in vitro. Similar results were obtained by Wang et al [38] in his study of pigs supplemented with 1 g/kg lactoferrin. Although, the villi in group CL are only slightly longer than villi of group Ci, without statistical significance, this result proves more consistent with the findings from the literature, which clearly demonstrates that there are highly effective mechanisms for maintaining the homeostasis of the intestinal epithelium [28][29][30].…”

Section: Histomorphometry Of the Intestinal Mucosasupporting

confidence: 80%

Histomorphometric study of role of lactoferrin in atrophy of the intestinal mucosa of rats

Caruso¹,

Demonte²,

Neves³

2012

Health

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The purpose of this work was to study the effects of oral administration of lactoferrin (Lf) in rats subjected to atrophy of the small intestine induced by a diet based on soy protein concentrate as the main protein source. We used 24 male Wistar rats aged 40 days, kept in individual cages under appropriate conditions of temperature, light and humidity. The animals were divided into four groups (n = 6); 1) group SL received soy-based food and, once a day, a supplement of 200mg/kg of Lf administered by gavage; 2) group Si received the soy feed without supplement of Lf; 3) group CL received a diet based on casein plus Lf; 4) group Ci received the casein diet without supplement of Lf. At the end of fifteen days, a 10 mm segment of the initial portion of the small intestine was sectioned and subjected to morphometry of the intestinal crypts and villi and assessment of the number and size of myofibroblasts. Comparison between groups showed that the length of the villi was similar in groups Ci and CL and higher in CL than in SL; SL than in Si, in Ci than in SL, and in Ci than in Si to Ci. The crypt depth was similar in SL and CL, SL and Ci and Ci and CL and was higher in Si than in Ci and in Si than in SL. The number of myofibroblasts was higher in SL than in CL, in SL than in Si, in CL than in Ci, and in SL than in and Ci; between Ci and Si there was no difference. The area of myofibroblasts was similar between the groups SL and CL and Si and Ci and higher in SL than in Si, and in Cl than in and Ci, and in SL than in Ci. All statistical analysis assumed significance when p < 0.05. From these results, we conclude that lactoferrin increases the number and size of the pericrypt myofibroblasts and stimulates rapidly the regeneration of atrophied villi.

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Section: Histomorphometry Of the Intestinal Mucosasupporting

confidence: 80%

Histomorphometric study of role of lactoferrin in atrophy of the intestinal mucosa of rats

Caruso¹,

Demonte²,

Neves³

2012

Health

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Section: Resultsunclassified

“…A lactoferrina, além de aumentar a altura das vilosidades, também reduz a profundidade das criptas quando adicionada em dietas de leitões (Wang et al, 2006). Adicionalmente, esse metabólito possui outras funções fisiológicas, como proteção contra infecções intestinais (Dial et al, 1998) e regulação da função imune (Lee, 1998 (Wang et al, 2006e Shan et al, 2007. A proibição pela União Europeia do uso de antibióticos como promotores de crescimento em dietas para leitões a partir de 1997 intensificou as pesquisas na busca de novas alternativas (Casewell et al, 2003).…”

Section: Resultsunclassified

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Alimentação de leitões com dietas contendo soro de leite fermentado mais zinco e cobre orgânico

Hauschild¹,

Lovatto²,

Lehnen³

et al. 2012

Arch. zootec.

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RESUMO SUMMARYAn experiment was carried out to evaluate the performance of piglets fed rations containing fermented milk and zinc and copper amino acid complex. Sixty four piglets, littermates, were used. The experimental design was based on random block with two dietary treatments. One of these contained a basal diet (DB) with ZnO e CuSO 4 and the other one with the DB, but without CuSO 4 and with the addition of fermented milk and zinc and copper amino acid complex (SLF Lact +ZnCuAA). There were eight replicate pens per treatment, and pigs were grouped at 4 per pen. The SLF Lact + ZnCuAA didn't not affect (p>0.05) final live weight of the piglets. However, live weight was different (p<0.01) between males and females (24.3 vs. 24.0 kg) at end of experiment. The feed intake of animals feed with SLFLact+ZnCuAA was higher (p<0.01) in 8% in the first 14 days (0.261 vs. 0.239 kg/d), 15% from 15 to 28 days (0.756 vs. 0.675 kg/

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“…In our previous study, we investigated effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets (Wang et al, 2006), and exploited the silkworm, Bombyx mori, as host for the recombinant baculovirus harboring the porcine lactoferrin (PLF) gene to produce the recombinant PLF (rPLF) (Wang et al, 2005a). In addition, we evaluated the developmental gene expression of lactoferrin (LF) and the effect of supplementary iron on gene expression of LF in the mammary gland of mice, which demonstated that iron significantly increased LF mRNA on d 1 and 25 of lactation (Wang et al, 2005b).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary bovine lactoferrin on lipid peroxidation and activities, and mRNA levels of antioxidant enzymes of piglets

Xu¹,

Wang²,

Liu³

et al. 2006

J. Anim. Feed Sci.

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The experiment was conducted to evaluate effect of dietary bovine lactoferrin (bLF) on lipid peroxidation and activities as well as mRNA levels of antioxidant enzymes of piglets. Duroc × Landrace × Yorkshire crossbred female piglets (n=120, 35 days of age, liveweight 9.70 ± 0.71 kg) were fed a diet containing 0, 1250, or 2500 mg/kg bLF for 30 days. After completion of the feeding experiment, twelve female piglets with 4 animals in each treatment were randomly selected to determine malondialdehyde (MDA) and total antioxidant capacity (TAOC) levelsczinc-superoxide dismutase (CuZnSOD), glutathione perioxidase (GPx), catalase (CAT) activities in serum and liver, and CuZnSOD, GPx and CAT mRNA levels in liver. Results showed that piglets treated with 2500 mg/kg bLF significantly increased (P<0.05) TAOC levels, the activities of GPx, CuZnSOD and CAT, and mRNA levels of CuZnSOD, GPx and CAT, and decreased (P<0.05) the contents of MDA as compared with control. Supplementation with 1250 mg/kg bLF also increased (P<0.05) the activities of CuZnSOD, GPx and CAT and mRNA levels of GPx and CAT, and decreased (P<0.05) the contents of MDA as compared with control, but the effect was not better than that of dietary addition of 2500 mg/kg bLF (P<0.05). The study indicated that addition of bLF improved the antioxidant function of piglets by up-regulation of mRNA levels and activities of certain antioxidant enzymes associated with free radicals metabolism.

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Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets1

Cited by 75 publications

References 32 publications

Histomorphometric study of role of lactoferrin in atrophy of the intestinal mucosa of rats

Histomorphometric study of role of lactoferrin in atrophy of the intestinal mucosa of rats

Alimentação de leitões com dietas contendo soro de leite fermentado mais zinco e cobre orgânico

Effect of dietary bovine lactoferrin on lipid peroxidation and activities, and mRNA levels of antioxidant enzymes of piglets

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