Effect of L-Carnitine Supplementation on Liver Enzymes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Askarpour, Moein; Djafarian, Kurosh; Ghaedi, Ehsan; Sadeghi, Omid; Sheikhi, Ali; Shab‐Bidar, Sakineh

doi:10.1016/j.arcmed.2019.12.005

Cited by 12 publications

(10 citation statements)

References 72 publications

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“…There is evidence indicating that some dietary interventions may be useful in reducing levels of ALT and AST. Results from interventional studies have indicated that increasing the consumption of nuts (Abazarfard, Eslamian, Salehi, & Keshavarzi, 2016), whole grains (Dorosti, Jafary Heidarloo, Bakhshimoghaddam, & Alizadeh, 2020), or supplementation of garlic (Panjeshahin & Mollahosseini, 2020) and L‐Carnitine (Askarpour et al, 2020) can reduce levels of ALT and AST.…”

Section: Discussionmentioning

confidence: 99%

What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials

Mousavi

Jayedi

Bagheri

et al. 2021

Phytotherapy Research

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Existing evidence has uncovered the potential health benefits of cinnamon intake; however, its effect on liver function is unclear. Thus, the aim of this systematic review and meta-analysis was to examine the effect of cinnamon supplementation on liver enzymes. Relevant articles were identified through a systematic search in PubMed/Medline, Scopus, Web of Science, Cochrane Library, and Embase up to September 2020. All trials assessing the effect of oral cinnamon supplementation on serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in adults were included. The pooled effect sizes were obtained using the random-effects model and expressed as mean difference (MD) and 95% confidence intervals (CI). A total of seven original trials (nine treatment arms) involving a total of 256 subjects were included in the final analysis. The pooled analysis indicated that cinnamon supplementation had no significant effect on serum levels of ALT, AST, and ALP. However, there was a significant reduction in ALT levels in patients with type 2 diabetes (MD: À4.01 U/L; 95% CI: À6.86, À1.15) and in trials with low-dose supplementation (<1,500 mg/d), follow-up duration longer than 12 weeks, and in the elderly patients (aged>50 years). The beneficial effects of cinnamon intake were also shown in AST levels in patients with type 2 diabetes and trials with long-term follow-up (>12 weeks). Longer-term, oral cinnamon supplementation may improve serum levels of liver enzymes in patients with type 2 diabetes. Further high-quality studies are needed, especially in populations with abnormal liver enzyme levels, to firmly establish the clinical efficacy of cinnamon on liver function.

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Section: Discussionmentioning

confidence: 99%

What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials

Mousavi

Jayedi

Bagheri

et al. 2021

Phytotherapy Research

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“…Decreases in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), liver fat, and serum alanine aminotransferase have also been reported [103]. Oral l-carnitine showed a hepatoprotective effect due to a decrease in the levels of gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase [104].…”

Section: Clinical Trialmentioning

confidence: 89%

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements

Durazzo¹,

Lucarini²,

Nazhand

et al. 2020

Molecules

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Carnitine can be considered a conditionally essential nutrient for its importance in human physiology. This paper provides an updated picture of the main features of carnitine outlining its interest and possible use. Particular attention has been addressed to its beneficial properties, exploiting carnitine’s properties and possible use by considering the main in vitro, in animal, and human studies. Moreover, the main aspects of carnitine-based dietary supplements have been indicated and defined with reference to their possible beneficial health properties.

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“…In recent prospective studies, GGT is considered as a sensitive indicator of liver damage and a novel marker for oxidative stress as well as for inflammation ( 56 , 57 ). In addition, there is an association between liver aminotransferase enzymes’ concentration (AST and ALT) and the quality of liver function ( 58 , 59 ). Based on previous reports, increased ALT levels in patients with NAFLD may be related to insulin resistance and intrahepatic fat content ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially in developed countries; yet the approaches for preventing and treating NAFLD are not clear. This study aimed to summarize meta-analyses of randomized controlled trials that examined the effects of probiotics on NAFLD. We systematically searched PubMed, Scopus, Embase, Web of Science, and Cochrane Central Library databases up to August 2021. All Meta-analysis studies assessing the effect of probiotics on liver function tests [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Gamma-glutamyl transferase (GGT)] were included. Meta-analysis was conducted using a random-effects model. Sensitivity and subgroup analyses were also performed. The umbrella study covered ten eligible studies involving 5,162 individuals. Beneficial effects of probiotics supplementation were revealed on ALT (ES = −10.54 IU/L; 95% CI: −12.70, −8.39; p < 0.001; I2 = 60.9%, p = 0.006), AST (ES = −10.19 IU/L, 95%CI: −13.08, −7.29, p < 0.001; I2 = 79.8%, p < 0.001), and GGT (ES = −5.88 IU/L, 95% CI: −7.09, −4.67, p = 0.009; I2 = 0.0%, p = 0.591) levels. Probiotics have ameliorating effects on ALT, AST, and GGT levels in patients with NAFLD. Overall, Probiotics could be recommended as an adjuvant therapeutic method for the management of NAFLD.

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Effect of L-Carnitine Supplementation on Liver Enzymes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 12 publications

References 72 publications

What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials

What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements

Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis

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