Effect of iron dextran, gold thiosulphate, and hydrocortisone acetate on experimental synovitis in the guinea pig.

Mowat, A G; Disney, T F; Vaughan, John H.

doi:10.1136/ard.30.2.187

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…T h e mean concentration of iron in rheumatoid synovial membrane was found to be 347 pg/g dry tissue compared with 15.2 pg/g in normal synovium (2), and it has been suggested that these deposits are unavailable for erythropoiesis possibly contributing to the anemia of rheumatoid arthritis (3). Controversy has arisen over whether these deposits exert a beneficial effect on the course of the arthritis (4) or are deleterious (5), and theories on their origin include a direct uptake from the plasma (6), a result of chronic intraarticular bleeding (3) and phag-ocytosis of leukocytes containing iron bound to cytoplasmic lactoferrin (4). Using an isotope kinetic method we have studied the rate of iron deposition in synovial membrane, its mechanism and whether there is any relationship to development of anemia in patients with rheumatoid arthritis.…”

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confidence: 99%

Synovial Iron Deposition in Rheumatoid Arthritis

Bennett

Williams

Lewis

et al. 1973

Arthritis & Rheumatism

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An isotope ferrokinetic study has been used to study the rate of iron deposition in 13 rheumatoid knees. Iron accumulation occurred only after incorporation of labelled iron into circulating erythrocytes, suggesting that intermittent intraarticular hemorrhages were the source of the deposits. The mean iron accumulation was 1.25 mg/knee/day representing a mean intraarticular blood loss of 3.58 ml. There was no correlation between the degree of iron deposition and the hemoglobin, platelet count or serum iron.

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confidence: 99%

Synovial Iron Deposition in Rheumatoid Arthritis

Bennett

Williams

Lewis

et al. 1973

Arthritis & Rheumatism

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“…Both mechanisms will induce a reduction in the number of leukocytes in the pouch fluid as we have detected. During inflammation, the synovial membrane acts as an extension of the reticuloendothelial system and the macrophages synthesize ferritin and store iron as ferritin and haemosiderin [17]. The administration of iron-dextran by an 8-hour infusion into a rheumatoid patient caused oxidant stress consisting of two phases: a direct pro-oxidant and proinflammatory effect of low-molecular-mass iron complexes; and a slower systemic response [18] was manifested around day 9.…”

Section: Discussionmentioning

confidence: 99%

Modulation of exudate inflammation parameters in rat carrageenan-induced granuloma by modification of exudate iron levels

et al. 1991

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We have used the carrageenan-induced pouch-granuloma in rats to investigate how changes in low-molecular-mass iron chelate levels in the exudate, induced by iron loading (iron-dextran) or chelation (desferrioxamine) influence cellular and systemic inflammatory parameters. In the iron-treated group we observed a rapid decrease in the number of leukocytes and exudate volume; there was also an increase in ferritin iron and low-molecular-mass iron chelates, and on the eighth day a systemic response. In the desferrioxamine-treated group we detected a decrease in low-molecular-mass iron chelates, ferritin iron, and an increase in the number of leukocytes. We describe the protective effects of desferrioxamine against the deleterious effects of ferrous iron and relate this to its chelating and scavenging activity. The results suggest that the levels of low-molecular-mass iron chelates modulate the inflammatory response, possibly through their contribution to the oxygen free radical generation, which is responsible for the cell membrane damage and subsequently its death. The modulatory action of iron-dextran and desferrioxamine support our hypothesis.

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“…Muirden (2) has suggested that iron may enhance tissue injury by causing lysosomes to release their enzymatic contents. On the other hand, Mowat et al (3) believe that iron may exert a beneficial effect in certain types of experimental synovitis.…”

Section: Inflammatory Arthritismentioning

confidence: 99%