Lactoferrin in synovial fluid of patients with inflammatory arthritis

E, DeCoteau; Yurchak, Anthony M.; Partridge, Raymond E. H.; Tomasi, Thomas B.

doi:10.1002/art.1780150317

Cited by 16 publications

(6 citation statements)

References 4 publications

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“…The contribution of plasma lysozyme to the SF values is unlikely to be significant because its plasma level is relatively low: -1.5 pg/ml (29). Because lactoferrin is not found in cartilage (25) or synovial membrane (21,24), and because it has recently been shown to be localized only to neutrophils in the peripheral blood (23), its level in synovial fluid can be taken as an index of neutrophil lysosomal activation. This application of the lactoferrin level was experimentally validated in the present study by its isochronous release with lysozyme and P-glucuronidase from phagocytosing human neutrophils ( Figure I).…”

Section: Discussionmentioning

confidence: 99%

Lactoferrin and lysozyme levels in synovial fluid

Bennett

Skosey

1977

Arthritis & Rheumatism

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Lysozyme and lactoferrin levels were measured in 71 synovial fluids (SF) of patients with traumatic effusions, osteoarthritis, rheumatoid arthritis, pseudogout, septic arthritis, and gout, as well as in 91 synovial fluids graded according to their neutrophil count. Elevated lysozyrne levels were found in all the inflammatory arthritides and also in osteoarthritis. Lactoferrin levels were not increased in osteoarthritis but displayed a close correlation to the extent of the inflammatory response as judged by SF neutrophilia. The ratio of lysozyme to lactoferrin decreased progressively with increasing SF neutrophilia. In vitro experiments showed that lactoferrin is released from neutrophils isochronously with lysozyme and pglucuronidase. Lactoferrin was not found in hyaline cartilage, a tissue known to contain lysozyme. These results are consistent with the belief that SF lysozyme has a major derivation from both cartilage and neutrophils, and that lactoferrin arises only from neutrophils. These find-

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Section: Discussionmentioning

confidence: 99%

Lactoferrin and lysozyme levels in synovial fluid

Bennett

Skosey

1977

Arthritis & Rheumatism

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“…In addition to the antimicrobial properties, Lf ability to modulate the overall immune response and to protect against viral infections and septic shock have been largely described (Legrand et al 2005;Valenti and Antonini 2005;Ward et al 2002). In this respect, it is noteworthy that Lf concentrations are elevated locally in inflammatory disorders including neurodegenerative diseases (Kawamata et al 1993), inflammatory bowel disease (Uchida et al 1994), arthritis (Decoteau et al 1972), and allergic inflammation (van de Graaf et al 1991). Although the cellular and molecular mechanisms accounting for the immunomodulatory effects of Lf are far from being fully elucidated, both in vitro and in vivo studies suggest the existence of multiple mechanisms that include modulation of cytokine/ chemokine production, regulation of reactive oxygen species production, and of immune cell recruitment.…”

Section: Introductionmentioning

confidence: 93%

Immunoregulatory role of lactoferrin-lipopolysaccharide interactions

et al. 2010

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Lactoferrin (Lf) is a mammalian exclusive protein widely distributed in milk and exocrine secretions exhibiting multifunctional properties. Many of the proven or proposed functions of Lf, apart from its iron binding activity, depend on its capacity to bind to other macromolecules. Lf can bind and sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis and tissue damage. However, the interplay between Lf and LPS is complex, and may result in different outcomes, including both suppression of the inflammatory response and immune activation. These findings are critically relevant in the development of Lf-based therapeutic interventions in humans. Understanding the molecular basis and functional consequences of Lf-LPS interaction will provide insights for determining its role in health and disease.

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“…However, it has multifunctional activities ranging from the intestinal iron absorption, intestinal cell growth augmentation, regulation of myelopoiesis and immune responses (Kanwar et al, 2008). Lf also has a defensive role in the body as its levels were found to be profoundly elevated in the pathological conditions such as the neurodegeneration (Leveugle et al, 1994), inflammatory diseases (Uchida et al, 1994), asthma and arthritis (Decoteau et al, 1972). In addition to this, bovine Lf (bLf) also exhibited potent anti‐cancer activities in the xenograft mice model including the inhibition of tumour metastasis (Kanwar et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Lactoferrin induced neuronal differentiation: A boon for brain tumours

Sriramoju

Kanwar

2014

Intl J of Devlp Neuroscience

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The cumulative treatments of bovine lactoferrin (bLf) and iron saturated lactoferrin (Fe-bLf) in the neuroblastoma cells showed neuronal differentiating actions evident with the expression of specific differentiating markers, β-tubulin III and neurofilaments. The protein treatments also showed lowered endogenous survivin that is responsible for cell proliferation and the miRNA 584 and miRNA214-3p, required for differentiation. Further, bLf adopted the PI3K signalling predominantly, while Fe-bLf involved both the PI3K and ERK signalling for inducing differentiation. In conclusion, this is the first study to report the neuronal differentiating effects of milk proteins and future studies are warranted for clinical application.

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Lactoferrin in synovial fluid of patients with inflammatory arthritis

Cited by 16 publications

References 4 publications

Lactoferrin and lysozyme levels in synovial fluid

Lactoferrin and lysozyme levels in synovial fluid

Immunoregulatory role of lactoferrin-lipopolysaccharide interactions

Lactoferrin induced neuronal differentiation: A boon for brain tumours

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