Immunoregulatory role of lactoferrin-lipopolysaccharide interactions

Puddu, P; Latorre, Daniela; Valenti, Piera; Gessani, Sandra

doi:10.1007/s10534-010-9307-3

Cited by 31 publications

(25 citation statements)

References 90 publications

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“…One potent pro-inflammatory mediator, tumoral necrosis factor (TNF), can cause septic shock and death when produced in large amounts in the systemic compartment [15]. Thus, by means of their LPS binding properties, Lf and Lfcn regulate both humoral and cellular inflammatory effectors, and this in turn can counteract the LPS-induced inflammatory response [16][17][18].…”

Section: A) Antimicrobial Properties B) Lps Neutralizing Propertiesmentioning

confidence: 99%

Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects

Drago-Serrano

Garza-Amaya

Luna

et al. 2012

International Immunopharmacology

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Section: A) Antimicrobial Properties B) Lps Neutralizing Propertiesmentioning

confidence: 99%

Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects

Drago-Serrano

Garza-Amaya

Luna

et al. 2012

International Immunopharmacology

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“…BME-UV1 cells have been treated with both LPS and bLf for 24 h, and the defensive role of bLf has been evaluated by MTT test. *P<0,05 of LPS by binding to their anionic lipid A portion (Appelmelk et al 1994;Puddu et al 2010). Several studies have documented the protective effect of Lf against endotoxinmediated damage.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective effect of bovine lactoferrin against lipopolysaccharides in a bovine mammary epithelial cell line

et al. 2010

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Lactoferrin (Lf) is a non-haem iron-binding glycoprotein with a molecular weight of about 80 kDa, synthesized by glandular epithelial cells and stored in the secondary granules of neutrophils. The physiological significance of Lf is related to non-specific immune defence against pathogens, immunomodulatory activity, iron homeostasis, antioxidant properties and regulation of cell growth. Lf is a bioactive component of the mammary secretions and its modulatory and defensive functions do affect the newborn and the mammary gland as well. In this work a bovine mammary epithelial cell line (BME-UV1) was used as an in vitro model of the bovine mammary epithelium to examine the protective role of exogenous bovine Lf (bLf) against the cytotoxic damage induced by bacterial lipopolysaccharides (LPS) and the endogenous bLf mRNA expression after LPS exposure. In the in vitro model used, exogenous bLf exerts a protective effect against endotoxin cytotoxicity, which could be mediated by the LPS-neutralizing capability of bLf. In addition, in BME-UV1 cells the response to LPS exposure does not involve bLf mRNA expression, suggesting that this cell line lack of functional LPS-responsive elements.

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“…competition with lactoferrin binding protein and CD14) and immune activation (e.g. induction of TLR4 signaling by lactoferrin or the lactoferrin-LPS complex) (Puddu et al, 2010;Latorre et al, 2012). In general, it is considered that lactoferrin neutralizes the effects of LPS because of its strong LPS-binding ability (Kutila et al, 2004;Kushibiki et al, 2008;Drago-Serrano et al, 2012).…”

Section: Antimicrobial Activities Of Lactoferrin Against Mastitis Patmentioning

confidence: 99%

Advances in lactoferrin research concerning bovine mastitis

Shimazaki

Kawai

2017

Biochem. Cell Biol.

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Lactoferrin is a multi-functional, iron-binding glycoprotein found in milk and other exocrine secretions. Lactoferrin in milk plays vital roles in the healthy development of newborn mammals and is also an innate resistance factor involved in the prevention of mammary gland infection by microorganisms. Inflammation of the udder due to bacterial infection is referred to as mastitis. There have been many investigations into the relationships between lactoferrin and mastitis, which fall into several categories. The main categories are fluctuations in the lactoferrin concentration of milk, lactoferrin activities against mastitis pathogens, elucidation of the processes underlying the onset of mastitis, participation of lactoferrin in the immune system, and utilization of lactoferrin in mastitis treatment and prevention. This review article describes lactoferrin research concerning bovine mastitis. In the 1970s, many researchers reported that the lactoferrin concentration fluctuates in milk from cows with mastitis. From the late 1980s, many studies clarified the infection-defense mechanism in the udder and the contribution of lactoferrin to the immune system. After 2000, the processes underlying the onset of mastitis were elucidated in vivo and in vitro, and lactoferrin was applied for the treatment and prevention of mastitis.

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Immunoregulatory role of lactoferrin-lipopolysaccharide interactions

Cited by 31 publications

References 90 publications

Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects

Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects

Evaluation of the protective effect of bovine lactoferrin against lipopolysaccharides in a bovine mammary epithelial cell line

Advances in lactoferrin research concerning bovine mastitis

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