Effect of intrauterine devices on sperm transport in the human being: Preliminary report

Tredway, Donald R.; Umezaki, Cesar U.; Mishell, Daniel R.; Settlage, Diane S. Fordney

doi:10.1016/0002-9378(75)90497-4

Cited by 42 publications

(5 citation statements)

References 3 publications

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“…In turn a smaller proportion of women using inert IUDs immediately before operation had oviductal sperm than the proportion found in subjects without IUDs. Both inert and copper IUDs were associated with delayed arrival of sperm into the oviducts [22][23][24][25][26][27] . Ortiz and Croxatto reported that in women with copper IUDs, a large proportion of oviductal sperm had undergone headtail separation 28 .…”

Section: Modes Of Action Of Copper Iudsmentioning

confidence: 99%

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

Sivin

Batar

2010

The European Journal of Contraception & Reproductive Health

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Since the 1959 revival of the IUD, non-hormonal devices have become the most widely used of all reversible contraceptives. Pregnancy rates of copper-releasing IUDs in current use range from approximately 0.5 to 1.5 per hundred continuing users in the first year, with somewhat lower annual pregnancy rates thereafter. Evidence-based research has been systematically conducted and translated into guidelines for eligibility criteria and problem management. Recent device research, beyond the T, Multiload and frameless devices has centred on improved designs such as U ,Y and Slimline shapes, or enhanced copper release, the latter through electrochemical effects or nanotechnology applications. Other IUD research foci concern devices that decrease bleeding and pain by releasing non-steroidal anti-inflammatory drugs. Yet other research lines indicate noncontraceptive benefits of copper intrauterine devices in protecting against endometrial cancer, and favourable risk-benefit analyses of IUD use by women at risk of or post HIV infection. IUD mechanisms of action and the relation of IUDs to pelvic infection and ectopic pregnancy are briefly reviewed. For our literature search we used Medline, Popline and Cochrane Library data bases, Google search, our personal files, and the references contained in articles in our files.

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Section: Modes Of Action Of Copper Iudsmentioning

confidence: 99%

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

Sivin

Batar

2010

The European Journal of Contraception & Reproductive Health

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“…Spermatozoa recovery techniques varied between studies and sometimes were not reported in adequate detail to allow for duplication. Nonetheless, after both groups were inseminated, dramatically reduced numbers of spermatozoa were recovered from the ampullary portion of fallopian tubes in women using a copper IUD in situ 13,15–17…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Long-term safety, efficacy, and patient acceptability of the intrauterine Copper T-380A contraceptive device

Kaneshiro

Aeby²

2010

IJWH

109

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The intrauterine device (IUD), primarily in the form of the copper IUD, is used by more than 150 million women around the world, making it the most widely used reversible method of contraception. With a remarkably low failure rate of less than 1 per 100 women in the first year of use, the Copper T-380A is in the top tier of contraceptives in terms of efficacy. Risks of utilization include perforation and an increased risk of infection in the first 20 days following insertion. Overall, the number of adverse events is low, making the Copper T-380A a very safe contraceptive method. The most common reasons for the discontinuation of this method are menstrual bleeding and dysmenorrhea. However, cumulative discontinuation rates of Copper T-380A are lower than that have been reported for other methods, indicating that the Copper T-380A is highly acceptable to women. After 5 years, approximately 50% of all women, who have a Copper T-380A inserted, will continue to use this highly effective contraceptive method.

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“…Copper affects the fertilizing capacity of human spermatozoa by interfering with sperm migration, viability, and acrosomal reaction in vitro(10–14). Recovery of viable spermatozoa near the site of fertilization is decreased in IUD users when compared to non-IUD users, yet hindrance of sperm migratory ability only diminishes the chance of fertilization.…”

Section: Introductionmentioning

confidence: 99%

Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device

Tetrault

Richman

Fei

et al. 2009

Fertility and Sterility

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Objective-To characterize human endometrial HOXA10 expression in patients using copper intrauterine devices (IUD).Design-Case-control study. Setting-Academic medical center Patient(s)-Women using copper IUDInterventions(s)-Immunohistochemical analysis of endometrial HOXA10 expression in biopsies obtained from 24 women using copper Paraguard T380A as well as in biopsies obtained from 10 normal cycling women who were not using IUD or hormonal contraceptives. Main Outcome Measure(s)-Endometrial HOXA10 expression.Result(s)-Endometrial HOXA10 expression was markedly decreased in biopsies obtained from women using IUD contraceptive when compared to controls. The mean H score for endometrial stromal cell HOXA10 expression in biopsies obtained from women using Paraguard IUD was 0.21 compared to 2.2 in the control endometrial biopsies (P<0.001). Endometrial glandular expression of HOXA10 was absent in all IUD users. Conclusion(s)-Decreasedendometrial HOXA10 expression was apparent in women who use a copper IUD. Expression of HOXA10 is essential for endometrial receptivity. A novel mechanism of copper IUD action involves suppression of genes required for endometrial receptivity. The dramatic decrease of endometrial HOXA10 in response to IUD use may contribute to contraceptive efficacy.

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Effect of intrauterine devices on sperm transport in the human being: Preliminary report

Cited by 42 publications

References 3 publications

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

Long-term safety, efficacy, and patient acceptability of the intrauterine Copper T-380A contraceptive device

Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device

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