Effect of Intranasal LHRH Therapy on Plasma Lh, FSH and Testosterone, and Relation to Clinical Results in Prepubertal Boys With Cryptorchidism

Illig, R; Torresani, Toni; Bucher, Hans Ulrich; Zachmann, M.; Prader, A.

doi:10.1111/j.1365-2265.1980.tb03137.x

Cited by 21 publications

(5 citation statements)

References 19 publications

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“…Illig et al [10,11] and Pirazzoli et al [13] confirmed this finding, correlating the results with age, the position of the testis [11,13] and with the pituitary reserve of gonadotropins before and after therapy.…”

Section: Introductionsupporting

confidence: 79%

Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue d-ser(TBU)6-LHRH-EA10

1982

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Abstract. Sixty-seven prepubertal boys with either uni-or bilateral cryptorchidism were treated with LH-RH or its analogue Hoe 766. In all cases the undescended testes were located in the inguinal canal; none had retractile testes.A) 23 boys were given 200 lag LH-RH-6 times daily for 7 days B) 24 boys were given 5001ag LH-RH-2 times daily for 7 days C) 10 boys received 100lag Hoe 766 every other day at 8 p.m.for a totaI of 8 insuffiations D) 10 boys received 25lag Hoe 766 every other day at 8 p.m.for a total of 8 insuffiations.The treatment was performed with control by LH-RH tests and testing the pituitary reserve of gonadotropins. Plasma testosterone was measured by RIA. Of the 47 boys treated with synthetic LH-RH, 14 (29.8%) gave a positive response with descent of the testes into the scrotum (A: 21.7%; B: 37.5%). The basal values and the pituitary reserves of LH and FSH did not change after therapy. Plasma testosterone showed an increase in the whole group of patients. Hoe 766 caused an increase in the FSH in all boys, but the curve was significantly higher in group C. There was no difference in plasma testosterone level between group C and D.None of the ten patients in group C responded to the therapy. In three patients of group D (30%) both testes descended. The administration of hCG to those boys who had not responded to the synthetic LH-RH or its analogue therapy led to the descent of three testes in group A and B, of two testes in group C, and of three testes in group D.Treatment of cryptorchidism by synthetic LH-RH or its analogue Hoe 766 for a short time can produce good results. The dosage of the drugs plays an important role in determining its effect.No change was found in gonadotropin secretion induced by synthetic LH-RH nasal spray therapy. The effect of intranasal administration of Hoe 766 is dose-dependent for FSH, but not for LH. When using synthetic LH-RH the best results were obtained by other authors with treatment of at least four weeks. The best results with synthetic or analogue LH-RH treatment were obtained in those subjects whose testes were located closer to the external ring. No side effects were observed either during or after the treatment.

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Section: Introductionsupporting

confidence: 79%

Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue d-ser(TBU)6-LHRH-EA10

1982

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“…There is some evidence that gonadotropins may exert a direct action, FSH being of importance (Illig et al, 1980).…”

Section: Results (Fig 1)mentioning

confidence: 98%

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

1980

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Synthetic LHRH was given intranasally to 55 prepubertal boys with 67 undescended testes. After a 4-5 week period while receiving a daily dose of 1.2 mg complete testicular descent was seen in 24 testes. Follow-up over 6 to 24 months showed relapse in 4 boys who responded successfully to a second trial with LHRH. In boys with insufficient or no response to an initial trial further treatment with LHRH in 11 cases or HCG in 5 cases also was without effect. Surgical correction after unsuccessful LHRH treatment in 32 boys with 35 undescended testes showed anatomical abnormalities in 28 testes, mostly an open processus vaginalis with or without hernia. Because of its simple and painless administration and the absence of unwanted side effects, intranasal LHRH is well-suited as initial treatment of cryptorchidism, particularly in young children.

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“…LHRH test. These results are in line with those of some of the previous studies (Happ et af., 1978;Illig et al, 1980;Hagberg & Westphal, 1982;Karpe et al, 1983), but contrary to others which found no changes (Pirazzoli et al, 1978;Spona et al, 1979;Hadziselirnovic et al, 1980;De Muinck Keizer-Schrama et af., 1984). The decreased FSH response to LHRH, found in our study, confirms the findings of most previous studies.…”

Section: Discussionmentioning

confidence: 74%

Effect of LHRH Treatment on Testicular Descent and Hormonal Response in Cryptorchidism

Wit

Waal

Bax

et al. 1986

Clinical Endocrinology

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In a double-blind placebo-controlled study in 49 boys with cryptorchidism the effect of intranasal synthetic LHRH was studied. After 8 weeks improvement in testicular location was found in 13 testes (37%), but this improvement was considered sufficient of only six testes. Placebo resulted in an improved location in 18% of the testes. The mean change in testicular position (expressed in cm) after LHRH therapy was slightly greater than after placebo but only in the squatting position did this difference reach significance. Aggressive behaviour was reported in 23% of the children treated with LHRH. A second LHRH course did not result in significant improvement in any of the patients. At follow-up reascent was frequently seen. The final results in unilateral cryptorchidism are poorer than those in bilateral cryptorchidism. LHRH therapy leads to higher plasma LH levels and a lower FSH in response to an intravenous LHRH test. In 15 boys plasma testosterone levels rose above 0.4 nmol/l. We conclude that intranasal LHRH application has a limited value for the treatment of cryptorchidism but may be suitable as a diagnostic test.

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Effect of Intranasal LHRH Therapy on Plasma Lh, FSH and Testosterone, and Relation to Clinical Results in Prepubertal Boys With Cryptorchidism

Cited by 21 publications

References 19 publications

Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue d-ser(TBU)6-LHRH-EA10

Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue d-ser(TBU)6-LHRH-EA10

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

Effect of LHRH Treatment on Testicular Descent and Hormonal Response in Cryptorchidism

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