Effect of LHRH Treatment on Testicular Descent and Hormonal Response in Cryptorchidism

Wit, J. M.; Waal, Henriëtte A. Delemarre-van de; Bax, N. M. A.; Brande, J. L. Van den

doi:10.1111/j.1365-2265.1986.tb03283.x

Cited by 16 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25,26 Three studies were of good quality, 17,23,25,26 2 were of fair quality, 14,15 and 9 were of poor quality. [9][10][11][12][13]16,[18][19][20][21][22]24 Six studies 9-16 specifically compared successful testicular descent rates after administration of LHRH versus placebo (2 fair quality 14,15 and 4 poor quality [9][10][11][12][13]16 ). Five of 6 studies concluded that LHRH was more effective than placebo in inducing testicular descent with variable reported effect sizes across studies, whereas 1 study was equivocal (see Table 2).…”

Section: Effectiveness Of Hormones For Achieving Testicular Descentmentioning

confidence: 99%

“…Five of 6 studies concluded that LHRH was more effective than placebo in inducing testicular descent with variable reported effect sizes across studies, whereas 1 study was equivocal (see Table 2). [12][13][14][15][16] In the 5 studies that appeared to show a benefit to LHRH therapy, 4 did not assess statistical significance at all, whereas 1 failed to document statistical significance likely because of inadequate sample size. No harms of hormonal treatment were reported.…”

Section: Effectiveness Of Hormones For Achieving Testicular Descentmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Hormonal and Surgical Therapies for Cryptorchidism: A Systematic Review

Penson¹,

Krishnaswami²,

Jules

et al. 2013

Pediatrics

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVE: Controversy remains concerning the optimal treatment approach for cryptorchidism. The objective of this study was to assess effectiveness of hormone therapy or surgery for cryptorchidism. METHODS: We searched Medline and other databases from 1980 to February 2012. Two reviewers independently assessed studies against predetermined criteria. Two reviewers independently extracted data and assigned overall quality and strength of evidence ratings using predetermined criteria. RESULTS: Fourteen studies addressed effectiveness of hormonal treatments, and 26 studies addressed surgical intervention outcomes. Hormonal treatment is associated with testicular descent in some children, but rates generally do not exceed those seen with placebo by >10%. Surgical treatment is associated with success rates of testicular descent ranging from 33% to 100%, depending on surgery. Weighted success averages were 78.7% for 1-stage Fowler-Stephens (FS), 86% for 2-stage FS, and 96.4% for primary orchiopexy. Descent rates were similar among studies comparing laparoscopic and open surgeries. Reported harms of hormonal treatments were mild and transient. Adverse effects specifically associated with surgical repair were rare. CONCLUSIONS: The body of the reviewed literature comprises primarily fair- and poor-quality studies, limiting our ability to draw definitive conclusions. Hormonal treatment is marginally effective relative to placebo but is successful in some children and with minimal harms, suggesting that it may be an appropriate trial of care for some patients. Surgical options are effective, with high rates of testicular descent (moderate strength of evidence for FS procedures, high for primary orchiopexy). Comparable outcomes occur with laparoscopic and open approaches.

show abstract

Section: Effectiveness Of Hormones For Achieving Testicular Descentmentioning

confidence: 99%

Section: Effectiveness Of Hormones For Achieving Testicular Descentmentioning

confidence: 99%

Effectiveness of Hormonal and Surgical Therapies for Cryptorchidism: A Systematic Review

Penson¹,

Krishnaswami²,

Jules

et al. 2013

Pediatrics

View full text Add to dashboard Cite

show abstract

“…In this respect the distance between a transverse plane through the pubic tubercle and the testicular midpoint has been proposed (Scorer -1964;Hosli -1971;Karpe et al -1983;Wit et al -1985). In this respect the distance between a transverse plane through the pubic tubercle and the testicular midpoint has been proposed (Scorer -1964;Hosli -1971;Karpe et al -1983;Wit et al -1985).…”

Section: Introductionmentioning

confidence: 99%

“…In this respect the distance between a transverse plane through the pubic tubercle and the testicular midpoint has been proposed (Scorer -1964;Hosli -1971;Karpe et al -1983;Wit et al -1985). Measurements of this distance have also been used to quantify the effect of intranasally administered LHRH (Luteinizing Hormone-Releasing Hormone) (Karpe et al -1983;Wit et al -1985). Measurements of this distance have also been used to quantify the effect of intranasally administered LHRH (Luteinizing Hormone-Releasing Hormone) (Karpe et al -1983;Wit et al -1985).…”

Section: Introductionmentioning

confidence: 99%

Intra- and Inter-Observer Variability in the Assessment of Testicular Descent

et al. 2009

View full text Add to dashboard Cite

Measurements of the distance between the testis and the pubic tubercle have been used to differentiate retractile testes from "real" cryptorchidism and to measure the effect of therapy. The intra-and inter-observer variation of these measurements was determined in 21 boys with incompletely descended testes treated with placebo. Patients were investigated in supine and squatting position, before and during moderate caudal traction. In squatting position the average distance is 20 mm greater than in supine position. The intra-observer SD is approximately 10 mm. It is doubtful if quantitative measurements can be used to define retractile testes. The wide prediction intervals should be taken into account in interpreting results of therapy. Die Variationsbreite innerhalb der Messungen des einzelnen Untersuchers und zwischen den Untersuchern in der Bewertung des HodendescensusZusammenfassung: Es wurden Messungen der Entfernung zwischen Hoden und Tuberculum pubicum angewandt, um retraktile Hoden von ,,richtigem" Kryptorchidismus zu unterscheiden und den Therapieerfolg zu beurteilen. Die Variationsbreite innerhalb der Messungen des einzelnen Untersuchers und zwischen den Untersuchern wurde ermittelt an 21 Jungen mit inkomplett descendierten Hoden, die mit Placebo behandelt wurden.Die Patienten wurden in Ruckenlage und in Hockstellung untersucht, vor und wahrend maSigem Zug nach kaudal. In Hockstellung ist die durchschnittliche Entfernung 20 mm groSer als in Ruckenlage. Die Standardabweichung innerhalb der Messungen des einzelnen Untersuchers ist ungefahr 10 mm. Es ist zweifelhaft, ob quantitative Messungen benutzt werden konnen, urn retraktile Hoden zu definieren.

show abstract

“…Since 1975 (14), luteinizing hormone-releasing hor¬ mone (LHRH) has been given in a nasal spray with promising results at first; later, this treatment did not prove to be successful (15,16).…”

mentioning

confidence: 99%

Effect of human chorionic gonadotrophin (hCG)/follicle-stimulating hormone treatment versus hCG treatment alone on testicular descent: a double-blind placebo-controlled study

Hoorweg-Nijman

Havers

Waal

1994

European Journal of Endocrinology

View full text Add to dashboard Cite

The medical treatment of retentio testis remains controversial because of ineffectiveness and/or adverse events. Follicle-stimulating hormone (FSH) seems to influence the spontaneous descent of the testis; furthermore, it induces luteinizing hormone (LH) receptors. Therefore, we performed a double-blind placebo-controlled study to investigate the effect of FSH with human chorionic gonadotrophin (hCG) versus hCG alone in retentio testis patients. Twenty-two boys with retentio testis were investigated, excluding retractile testis. Group A (N = 14: four with bilateral and 10 with unilateral retentio testis; mean age 3.15 years) was treated with 150 IU of FSH twice a week for 2 weeks followed by 150 IU of FSH and 250 IU of hCG (half the recommended World Health Organization dose) twice a week for another 4 weeks. Group B (N = 8: two with bilateral and six with unilateral retentito testis; mean age 3.3 years) was treated with 250 IU of hCG twice a week for 6 weeks. Testicular position, volume and consistency as well as the appearance of the scrotum and the penile length were determined at the start of the treatment as well as at weeks 2, 4, 6 and 12 by two independent investigators. Blood investigation consisted of measurements of LH, FSH, testosterone and sex hormone-binding globulin. Successful descent was considered when the testis reached a mid- or low scrotal position. In group A, 6/18 testes descended successfully. In group B, 6/10 testes descended. Of the unsuccessfully treated patients, six of group A and three of group B underwent surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Effect of LHRH Treatment on Testicular Descent and Hormonal Response in Cryptorchidism

Cited by 16 publications

References 20 publications

Effectiveness of Hormonal and Surgical Therapies for Cryptorchidism: A Systematic Review

Effectiveness of Hormonal and Surgical Therapies for Cryptorchidism: A Systematic Review

Intra- and Inter-Observer Variability in the Assessment of Testicular Descent

Effect of human chorionic gonadotrophin (hCG)/follicle-stimulating hormone treatment versus hCG treatment alone on testicular descent: a double-blind placebo-controlled study

Contact Info

Product

Resources

About