Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

Illig, R; Bucher, Hans Ulrich; Prader, A.

doi:10.1007/bf00441583

Cited by 21 publications

(5 citation statements)

References 8 publications

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“…In this collaborative study involving a large number of 119 cryptorchid patients who were prospectively treated and followed up, the overall success rate of complete testicular 80% (15). This is in contrast to the findings of Illig et al who reported that hCG treatment given to four boys unresponsive to LHRH treatment had no effect on testicular position (13). The same authors stated that a second trial of intranasal LHRH in 17 boys with no or insufficient response to the initial LHRH treatment was ineffective, regardless whether it followed immediately after the first course or whether it was repeated weeks or months later.…”

Section: Discussioncontrasting

confidence: 58%

“…Two studies were conducted double-blind and included 84 and 100 patients, respectively (10, 16). This is in contrast to the findings of Illig et al who reported that hCG treatment given to four boys unresponsive to LHRH treatment had no effect on testicular position (13). Success rates in therapeutic trials with this drug have generally varied between 3 0 4 0 % (9-16) and could not be increased by treatment periods of more than four weeks (9-1 1, 13).…”

Section: Discussionmentioning

confidence: 88%

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Success and Relapse Rate after Treatment of Cryptorchidism with Intranasal LHRH

1985

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In a collaborative study 119 cryptorchid prepubertal children with 67 unilaterally and 104 bilaterally undescended testes were treated for four weeks with intranasal LHRH 1.2 mg daily. The age range was 1 1/12 to 12 3/12 years with a median of 3 10/12 years. Complete descent was observed in 64 testes (37%) and partial descent in another 47 testes (27%). Positive responders were equally distributed in all age groups. At a follow-up of 57 patients at least six months after the end of treatment, 40% of the previously fully descended testes were found at higher locations, more than half at the scrotal neck. We conclude that LHRH therapy for cryptorchidism is effective and without any major side-effects. It may be particularly useful in children of one to three years of age where hCG is practically useless and surgical repair is the only alternative to date. However, efforts should be directed towards elaboration of treatment schedules which would avoid the high relapse rate.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 88%

Success and Relapse Rate after Treatment of Cryptorchidism with Intranasal LHRH

1985

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“…Nasal application of LH-RH has been shown to give therapeutic effect in about 30-60% of patients with undescended testes (Illig et al 1977(Illig et al , 1980Pirazolli et al 1978;Had~iselimovia 1982). In both these studies comprising 96 treated patients with a total of 116 undescended testes a therapeutic result was found in about 60% and a complete descent was found in about 40%.…”

Section: Discussionmentioning

confidence: 98%

“…injections for 14 days. When synthetic LH-RH preparations for intranasal application were available, several studies on treatment of undescended testes have been presented (Happ et al 1975(Happ et al , 1978Illig et al 1977Illig et al , 1980Pirazolli et al 1978). Success rate varies between 30 and 60%.…”

Section: Introductionmentioning

confidence: 97%

Treatment of undescended testes with intranasal application of synthetic LH-RH

Hagberg¹,

Westphal²

1982

Eur J Pediatr

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The effect of intranasal, synthetic LH-RH (Hoe 471) on undescended testes was investigated in: I. a double blind study comprising 50 patients given either placebo or 0.6 mg LH-RH daily and II. an open study comprising 50 patients with a daily dosage of 1.2 mg LH-RH. In both studies LH-RH was given for 4 weeks. Since some patients had bilateral undescended testes, 116 testes were treated in total. Patients' ages varied between 1 1/2 and 10 1/2 years, with a mean of 5 years. Clinical examination before, during and at end of treatment was performed by both the authors independently. In the placebo group, one testicular descent was seen, indicating difficulty in diagnosis. A therapeutic result, i.e. a significant move from the pretreatment location towards the bottom of the scrotum was seen in 60% of the testes, complete descent being seen in about 40%. In a follow-up study 6 months after treatment, in 23 cases with complete descent from a pretreatment inguinal position, relapse was seen in 5 patients (2 were located at scrotal neck, 3 at the pretreatment position i.e. inguinal). The best results were seen on testes located not too far from the scrotal neck, with the higher dosage of LH-RH and in patients less than 6 years of age. No significant hormonal changes (testosterone-, LH- or FSH-levels in peripheral blood) were seen during the study. Side effects were negligible.

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“…Many patients receiving the 6 week stimulation, had hormonal levels obtained at 6 weeks but also after 6 days, and 3 weeks. Assay procedures for LH, FSH,9 and testosteronel° were carried out as previously reported.…”

Section: Methodsmentioning

confidence: 97%

HCG Stimulation in Children With Cryptorchidism

Urban

Lee

Lanes

et al. 1987

Clin Pediatr (Phila)

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Fifty-eight children with cryptorchidism have been given hCG stimulation testing, 31 with bilateral cryptorchidism, 22 with unilateral, and 5 with prior unsuccessful orchiopexy. Hormonal studies were carried out prior to and following stimulation. In bilateral cryptorchidism, bilateral descent was observed in 32 percent of cases and in unilateral, the success rate was 55 percent. From their data, the authors concluded that hCG is not indicated if patients present elevated LH and FSH levels or if the basal T levels are in the pubertal range. In the other subjects, the hCG test will permit the determination of the presence or absence of testosterone production and in some cases it results in testicular descent. Finally, in cases of failure that require surgery, the hCG will stimulate tissue growth enhancing the success of orchiopexy.

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Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

Cited by 21 publications

References 8 publications

Success and Relapse Rate after Treatment of Cryptorchidism with Intranasal LHRH

Success and Relapse Rate after Treatment of Cryptorchidism with Intranasal LHRH

Treatment of undescended testes with intranasal application of synthetic LH-RH

HCG Stimulation in Children With Cryptorchidism

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