Effect of inorganic salt on the dose sensitivity of polymer gel dosimeter

Hayashi, Shin-ichiro; Fujiwara, Fumiya; Usui, Shuji; Tominaga, Takahiro

doi:10.1016/j.radphyschem.2012.03.001

Cited by 37 publications

(7 citation statements)

References 21 publications

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“…Moreover, it was suggested that to increase the upper dose range, the yield of ferric ions may be reduced by adding the cupric sulfate to the solution. Such a ferrous cupric sulfate dosimeter would increase the upper range limit to few rads; i.e., in a biologically significant region (44,45). On the other hand, the lower dose range of the Fricke dosimeter can be extended by increasing the yield of ferric ions.…”

Section: Discussionmentioning

confidence: 99%

Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography

et al. 2022

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PurposeAssessment of the radiation dose delivered to a tumor and different organs is a major issue when using radiolabelled compounds for diagnostic imaging or endoradiotherapy. The present article reports on a study to correlate the mean 18F-fluorodeoxyglucose (18F-FDG) activity in different tissues measured in a mouse model by positron emission tomography (PET) imaging, with the dose assessed in vitro by Fricke dosimetry.MethodsThe dose-response relationship of the Fricke dosimeter and PET data was determined at different times after adding 18F-FDG (0–80 MBq) to a Fricke solution (1 mM ferrous ammonium sulfate in 0.4 M sulfuric acid). The total dose was assessed at 24 h (~13 half-lives of 18F-FDG). The number of coincident events produced in 3 mL of Fricke solution or 3 mL of deionized water that contained 60 MBq of 18F-FDG was measured using the Triumph/LabPET8TM preclinical PET/CT scanner. The total activity concentration measured by PET was correlated with the calculated dose from the Fricke dosimeter, at any exposure activity of 18F-FDG.ResultsThe radiation dose measured with the Fricke dosimeter increased rapidly during the first 4 h after adding 18F-FDG and then gradually reached a plateau. Presence of non-radioactive-FDG did not alter the Fricke dosimetry. The characteristic responses of the dosimeter and PET imaging clearly exhibit linearity with injected activity of 18F-FDG. The dose (Gy) to time-integrated activity (MBq.h) relationship was measured, yielding a conversion factor of 0.064 ± 0.06 Gy/MBq.h in the present mouse model. This correlation provides an efficient alternative method to measure, three-dimensionally, the total and regional dose absorbed from 18F-radiotracers.ConclusionsThe Fricke dosimeter can be used to calibrate a PET scanner, thus enabling the determination of dose from the measured radioactivity emitted by 18F-FDG in tissues. The method should be applicable to radiotracers with other positron-emitting radionuclides.

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Section: Discussionmentioning

confidence: 99%

Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography

et al. 2022

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“…Many works have reported the influence of different salts on the performance of gel dosimeters. The literature shows a significant effect of specific inorganic salts on the dose response of irradiated gels [ 38 , 39 , 40 , 41 , 42 ]. The polymerization of polymer gels has been dramatically increased and enhanced by the addition of inorganic salts that attract water molecules and other elements via electrostatic interactions in the gel, leading to an increase in the rate of polymerization [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…The literature shows a significant effect of specific inorganic salts on the dose response of irradiated gels [ 38 , 39 , 40 , 41 , 42 ]. The polymerization of polymer gels has been dramatically increased and enhanced by the addition of inorganic salts that attract water molecules and other elements via electrostatic interactions in the gel, leading to an increase in the rate of polymerization [ 40 ]. Rabeah et al (2017) [ 37 ] introduced the composition of a polymer gel that contains N -(hydroxymethyl)acrylamide monomer (NHMA).…”

Section: Introductionmentioning

confidence: 99%

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Rabaeh

Al-Tarawneh

Eyadeh

et al. 2022

Gels

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The impact of calcium chloride (CaCl2) on the performance of N-(hydroxymethyl)acrylamide (NHMA) polymer gel dosimeter is studied in this article. The dosimeter was exposed to doses of up to 10 Gy with radiation beam-energy of 10 MV and dose-rates of 300 cGy/min. The relaxation rate (R2) parameter was utilized to explore the performance of irradiated NHMAGAT gels. The dose response in terms of R2 increased from 0.29 to 0.63 Gy−1·s−1 with increasing calcium chloride concentration from 0 to 1000 mM. The results show no substantial impact of dose-rates as well as radiation energies on NHMAGAT samples. For the steadiness of irradiated NHMAGAT dosimeters, it was found that there is no apparent variation in R2 (less than ±3%; standard deviation) up to 3 days. The overall uncertainty of the gel dosimeter with calcium chloride is 4.96% (double standard deviation, 95% confidence level).

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“…As a typical gel dosimeter, 7 there are Fricke gel [8][9][10][11] and polymer gel [12][13][14][15] dosimeters, and many radiosensitizers 2, [16][17][18][19][20] have been investigated because improving sensitivity is an issue, up to now. On the other hand, there are not many reports in the gel dosimeters utilizing uorometry using radiosensitizers, although there are several type of radio-uorogenic gels.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides

et al. 2020

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Effect of inorganic salt on the dose sensitivity of polymer gel dosimeter

Cited by 37 publications

References 21 publications

Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography

Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides

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