Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides

Mochizuki, Anri; Maeyama, Takashige; Watanabe, Yusuke; Mizukami, Shinya

doi:10.1039/d0ra02717k

Cited by 15 publications

(5 citation statements)

References 42 publications

(50 reference statements)

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“…For more detailed characterization, it is necessary to improve the sensitivity or change the measurement system. For example, it is useful to investigate the application of a gel dosimeter using the most sensitive fluorescent probe [16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Effects of radical scavengers on nanocomposite Fricke gel for heavy ion beam irradiation

Maeyama

Fukunishi

Ishikawa

et al. 2022

J. Phys.: Conf. Ser.

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Section: Discussionmentioning

confidence: 99%

Effects of radical scavengers on nanocomposite Fricke gel for heavy ion beam irradiation

Maeyama

Fukunishi

Ishikawa

et al. 2022

J. Phys.: Conf. Ser.

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“…To enhance the sensitivity of fluorescent clay-based gel dosimeters, surfactants, which included polyethylene glycol octylphenyl ether (Triton X-100), sodium dodecyl sulfate, and cetyltrimethylammonium bromide (CTAB), were introduced to them. Furthermore, halides such as trichloroacetic acid, tribromoacetic acid and 2,2,2-trichloroethanol were also found to improve the dosimeter sensitivity [69]. It should be noted that pH significantly affects the peak excitation and the sensitivity of the radio-fluorogenic gel dosimeters [70].…”

Section: Radio-fluorogenic Gel Dosimetersmentioning

confidence: 95%

Recent Advances in Hydrogel-Based Sensors Responding to Ionizing Radiation

Zhang

Jiang

Chen

et al. 2022

Gels

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Ionizing radiation and its applications are widely spread throughout life. Similar to many other things, both the positive and negative aspects of ionizing radiation should always be kept in mind. For example, a proper radiation dose can be delivered to tumor tissue to kill malignant cells in radiotherapy. On the other hand, exceeding this dose can damage the normal tissues of a human organism. Therefore, the application of sensors for measuring ionizing radiation doses is of utmost importance in many fields, especially in cancer therapy. Traditional dosimeters, such as ionization chambers, silicon diodes and thermoluminescence dosimeters, are widely used. However, they have limitations in certain aspects. Hydrogel-based sensors (or dosimeters) for measuring ionizing radiation doses attract extensive attention for decades due to their equivalence to living tissue and biocompatibility. In this review, we catalog hydrogel-based dosimeters such as polymer, Fricke, radio-chromic, radio-fluorescence and NPs-embedded dosimeters. Most of them demonstrate desirable linear response and sensitivity regardless of energy and dose rate of ionizing radiation. We aim to review these dosimeters and their potential applications in radiotherapy as well as to stimulate a joint work of the experts from different fields such as materials science, chemistry, cancer therapy, radiobiology and nuclear science.

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“…Because of these additives to the composition of NC-RFG-DHR 123, it has become the most sensitive gel dosimeter able to measure doses of the order of 0.1 Gy. 149 However, the exciting light used in the dose readout by fluorometry, can produce extraneous signals with intensities that cannot be neglected in the range of a subGray dose. For that reason, new additives to NC-RFG-DHR 123 namely, N-vinylpyrrolidone (NVP) or pyridine were investigated to suppress the light sensitivity to at least 10% of ordinary conditions, resulting in a detection limit of about 0.1 Gy.…”

Section: Enhancement Of Various Radiation Dosimetry Systems Using Nan...mentioning

confidence: 99%

Review of nanomaterial advances for ionizing radiation dosimetry

Aboelezz

Pogue

2023

Applied Physics Reviews

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There are a wide range of applications with ionizing radiation and a common theme throughout these is that accurate dosimetry is usually required, although many newer demands are provided by improved features in higher range, multi-spectral and particle type detected. Today, the array of dosimeters includes both offline and online tools, such as gel dosimeters, thermoluminescence (TL), scintillators, optically stimulated luminescence (OSL), radiochromic polymeric films, gels, ionization chambers, colorimetry, and electron spin resonance (ESR) measurement systems. Several future nanocomposite features and interpretation of their substantial behaviors are discussed that can lead to improvements in specific features, such as (1) lower sensitivity range, (2) less saturation at high range, (3) overall increased dynamic range, (4) superior linearity, (5) linear energy transfer and energy independence, (6) lower cost, (7) higher ease of use, and (8) improved tissue equivalence. Nanophase versions of TL and ESR dosimeters and scintillators each have potential for higher range of linearity, sometimes due to superior charge transfer to the trapping center. Both OSL and ESR detection of nanomaterials can have increased dose sensitivity because of their higher readout sensitivity with nanoscale sensing. New nanocrystalline scintillators, such as perovskite, have fundamentally important advantages in sensitivity and purposeful design for key new applications. Nanoparticle plasmon coupled sensors doped within a lower Zeff material have been an effective way to achieve enhanced sensitivity of many dosimetry systems while still achieving tissue equivalency. These nanomaterial processing techniques and unique combinations of them are key steps that lead to the advanced features. Each must be realized through industrial production and quality control with packaging into dosimetry systems that maximize stability and reproducibility. Ultimately, recommendations for future work in this field of radiation dosimetry were summarized throughout the review.

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Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides

Abstract: Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials using high sensitive radio-fluorogenic gel dosimeter using DHR123 with sensitizer. (Radiation therapy planning image courtesy of Varian Medical Systems, Inc. All rights reserved.)

Cited by 15 publications

References 42 publications

Effects of radical scavengers on nanocomposite Fricke gel for heavy ion beam irradiation

Effects of radical scavengers on nanocomposite Fricke gel for heavy ion beam irradiation

Recent Advances in Hydrogel-Based Sensors Responding to Ionizing Radiation

Review of nanomaterial advances for ionizing radiation dosimetry

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