2012
DOI: 10.1590/s1516-635x2012000100011
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Effect of inoculation route on the production of antibodies and histological characteristics of the spleen in laying hens

Abstract: Recent studies have reported the use of IgY antibody in the prevention or treatment of diseases in animals. IgY can be obtained in large amounts from the yolk of chicken eggs through a low-cost process. This study evaluated the effect of different routes of inoculation on antibody production and spleen morphological characteristics of laying hens (White Leghorn) inoculated with sheep red blood cells. The analysis of the results showed that the intramuscular route is the most efficient for total antibody produc… Show more

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Cited by 10 publications
(8 citation statements)
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“…http://dx.doi.org/10.1590/1678-4162-9063 geradas na expansão clonal, migram para a medula óssea e residem no tecido como células de memória (Eto et al, 2012).…”
Section: This Work Aimed To Evaluate the Role Of The Spleen In Storagunclassified
“…http://dx.doi.org/10.1590/1678-4162-9063 geradas na expansão clonal, migram para a medula óssea e residem no tecido como células de memória (Eto et al, 2012).…”
Section: This Work Aimed To Evaluate the Role Of The Spleen In Storagunclassified
“…Chang et al (1999), using S. mutans to compare the effects of IM and SC routes, showed that the production of IgY via IM was almost 10 times greater than through SC. Furthermore Eto et al (2012), using sheep red blood cells as the antigen observed that the intravenous route resulted in a better response when compared with IM and SC, although there were no significant differences in the levels of antibodies produced by these two routes.…”
Section: Routes Of Inoculation and Igy Productionmentioning
confidence: 94%
“…The most common routes for antigen inoculation are IM, SC, and ID routes Eto et al, 2012;Murphy, Tavares, & Walport, 2010). In laying hens, the IM route is the most commonly used for production of antibodies (Schade et al, 2005).…”
Section: Routes Of Inoculation and Igy Productionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is a great interest in the production of specific antibodies in laying hens for immunotherapy and immunodiagnostics to replace antibodies produced in mammalians (MONTINI et al, 2018;MARCQ et al, 2015;MARCQ et al, 2013;ETO et al, 2012). Laying hens represent an alternative to mammalians due to the possibility of obtaining large quantities of IgY from egg yolk at a low cost (MUNHOZ et al, 2014).…”
Section: Introductionmentioning
confidence: 99%