Effect of inhaled corticosteroid on TNF-α production and alveolar bone loss in Wistar rats

Daudt, Luciana Dondonis; Cavagni, Juliano; Gaio, Eduardo José; Souza, Andressa de; Torres, Iraci Lucena da Silva; Ferreira, Maria Beatriz Cardoso; Rösing, Cassiano Kuchenbecker

doi:10.1016/j.archoralbio.2011.04.018

Cited by 6 publications

(8 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 99%

“…The present study was conducted in Wistar rats, which are widely used in studies on pathogenesis of both periodontal diseases and metabolic disorders, being a recognized and adequate model with some translational potential. 18,19,[29][30][31][32][33] A high-fat and hypercaloric diet was used for a period of 12 weeks before the induction of periodontal breakdown, a regimen able to induce obesity and hyperlipidemia. 19,22,23 At the end of the experiment, parameters of obesity-associated metabolic disorders were checked.…”

Section: Discussionmentioning

confidence: 99%

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Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

Cavagni

Macedo

Gaio

et al. 2016

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

Cavagni

Macedo

Gaio

et al. 2016

Journal of Periodontology

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“…This might be due to inappropriate formulation and dosage. Additional studies are needed to estimate the effects of budesonide on the oral mucosa and the periodontium (Daudt et al, 2011).…”

Section: Corticosteroids For Local Application On the Periodontiummentioning

confidence: 99%

Therapeutic strategies in the treatment of periodontitis

Bogdanovska¹,

Kukeska²,

Поповска³

et al. 2012

Maced. Pharm. Bull.

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Periodontitis is a chronic inflammatory process which affects the tooth - supporting structures of the teeth. The disease is initiated by subgingival periopathogenic bacteria in susceptible periodontal sites. The host immune response towards periodontal pathogens helps to sustain periodontal disease and eventual alveolar bone loss. Although scaling and root planing is the standard treatment modality for periodontitis, it suffers from several drawbacks such as the inability to reach the base of deep pockets and doesn’t arrest migration of periodontal pathogens from other sites in the oral cavity. In order to overcome the limitations of scaling and root planning, adjunctive chemotherapeutics and host modulatory agents to the treatment are used. These therapeutic agents show substantial beneficial effects when compared to scaling and root planning alone. This review will cover an update on chemotherapeutic and past and future host immune modulatory agents used adjunctively to treat and manage periodontal diseases.

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“…These measurements enable metrical quantification of the result and of the inflammatory process. For this purpose, different methods for measuring alveolar bone loss in rats have been proposed in the literature, such as histometric, 3 morphometric [4][5][6] conventional radiographic measurements 7 and computed tomography. 8,9 Different studies have sought to demonstrate the ability to measure periodontal destruction by different methods and effectively quantify the effect caused by the experimental model of periodontal disease.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…The hemimaxillae were placed with the occlusal surface parallel to the floor. 4,5,10,6,13 Buccal/palatal morphometric analysis…”

Section: Specimen Preparationmentioning

confidence: 99%

Correlation analysis of alveolar bone loss in buccal/palatal and proximal surfaces in rats

Azambuja¹,

Cavagni²,

Wagner³

et al. 2012

Braz. oral res.

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Abstract:The aim was to correlate alveolar bone loss in the buccal/palatal and the mesial/distal surfaces of upper molars in rats. Thirty-three, 60-day-old, male Wistar rats were divided in two groups, one treated with alcohol and the other not treated with alcohol. All rats received silk ligatures on the right upper second molars for 4 weeks. The rats were then euthanized and their maxillae were split and defleshed with sodium hypochlorite (9%). The cemento-enamel junction (CEJ) was stained with 1% methylene blue and the alveolar bone loss in the buccal/palatal surfaces was measured linearly in 5 points on standardized digital photographs. Measurement of the proximal sites was performed by sectioning the hemimaxillae, restaining the CEJ and measuring the alveolar bone loss linearly in 3 points. A calibrated and blinded examiner performed all the measurements. Intraclass Correlation Coefficient revealed values of 0.96 and 0.89 for buccal/lingual and proximal surfaces, respectively. The Pearson Correlation Coefficient (r) between measurements in buccal/ palatal and proximal surfaces was 0.35 and 0.05 for the group treated with alcohol, with and without ligatures, respectively. The best correlations between buccal/palatal and proximal surfaces were observed in animals not treated with alcohol, in sites both with and without ligatures (r = 0.59 and 0.65, respectively). A positive correlation was found between alveolar bone loss in buccal/palatal and proximal surfaces. The correlation is stronger in animals that were not treated with alcohol, in sites without ligatures. Areas with and without ligature-induced periodontal destruction allow detection of alveolar bone loss in buccal/palatal and proximal surfaces.

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Effect of inhaled corticosteroid on TNF-α production and alveolar bone loss in Wistar rats

Abstract: Inhaled budesonide in different concentrations did not alter alveolar bone loss and TNF-α secretion in male Wistar rats.

Cited by 6 publications

References 33 publications

Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

Therapeutic strategies in the treatment of periodontitis

Correlation analysis of alveolar bone loss in buccal/palatal and proximal surfaces in rats

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